Official EU label nameGlossary entry 9106

DIOSGENIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:512-04-9

EC:208-134-3

Ingredient index records:

DIOSGENIN

Cosmetic functions: SKIN CONDITIONING

(20R,25R)-spirost-5-en-3β-ol

Inventory restriction note: II/260

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1 matched or reported name

DIOSGENIN

Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name DIOSGENIN.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 512-04-9

CAS 512-04-9PubChem CID 99474

Diosgenin

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone. It has a role as an antiviral agent, a metabolite, an antineoplastic agent and an apoptosis inducer. It is a sapogenin, a 3beta-sterol, a hexacyclic triterpenoid and a spiroketal. It derives from a hydride of a spirostan. — ChEBI

IUPAC name: (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol

Molecular formula: C27H42O3
Molecular weight: 414.6 g/mol
Exact mass: 414.31339520 Da
XLogP3: 5.7
Topological polar surface area: 38.7 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 11

Also known as

Nitogenin(3beta,25R)-spirost-5-en-3-olK49P2K8WLXCHEBI:4629(25R)-spirost-5-en-3beta-diolSpirost-5-en-3-ol, (3beta,25R)-NSC-33396(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro(5-oxapentacyclo(10.8.0.02,9.04,8.013,18)icos-18-ene-6,2'-oxane)-16-ol

16 more reported names

RefChem:5766208-134-3DiosgenineDISOGENIN(25R)-Spirost-5-en-3beta-ol(20R,25R)-Spirost-5-en-3beta-olNSC 33396(25R)-14beta,17beta-spirost-5-en-3beta-olSP 37Spirost-5-en-3beta-ol, (25R)-UNII-K49P2K8WLXSpirost-5-en-3-ol, (3b,25R)-nitrogen inCCRIS 6803Diosgenin CRS22alpha-Spirost-5-en-3beta-ol

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External database identifiers

ChEBI:CHEBI:4629
ChEMBL:CHEMBL412437
EPA DTXSID:DTXSID00895074
PubMed:39536891
PubMed:39395682
PubMed:39059093
PubMed:35305976
PubMed:35149085
PubMed:34806916
PubMed:33383043
PubMed:32347045
PubMed:28106847
PubMed:26408789
PubMed:25446497
PubMed:24001619

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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