What does the restriction note for DIOSGENIN mean?

The restriction field for DIOSGENIN reads: II/260. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 512-04-9?

CAS 512-04-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains DIOSGENIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 8364615/10/2010

DIOSGENIN

(20R,25R)-spirost-5-en-3β-ol

DIOSGENIN is linked to 1 EU annex record on this page. Inventory note: II/260.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 512-04-9

CAS 512-04-9PubChem CID 99474

Diosgenin

Diosgenin is a sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone. It has a role as an antiviral agent, a metabolite, an antineoplastic agent and an apoptosis inducer. It is a sapogenin, a 3beta-sterol, a hexacyclic triterpenoid and a spiroketal. It derives from a hydride of a spirostan. — ChEBI

IUPAC name: (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol

Molecular formula: C27H42O3
Molecular weight: 414.6 g/mol
Exact mass: 414.31339520 Da
XLogP3: 5.7
Topological polar surface area: 38.7 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 11

Also known as

Nitogenin(3beta,25R)-spirost-5-en-3-olK49P2K8WLXCHEBI:4629(25R)-spirost-5-en-3beta-diolSpirost-5-en-3-ol, (3beta,25R)-NSC-33396(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro(5-oxapentacyclo(10.8.0.02,9.04,8.013,18)icos-18-ene-6,2'-oxane)-16-ol

16 more reported names

RefChem:5766208-134-3DiosgenineDISOGENIN(25R)-Spirost-5-en-3beta-ol(20R,25R)-Spirost-5-en-3beta-olNSC 33396(25R)-14beta,17beta-spirost-5-en-3beta-olSP 37Spirost-5-en-3beta-ol, (25R)-UNII-K49P2K8WLXSpirost-5-en-3-ol, (3b,25R)-nitrogen inCCRIS 6803Diosgenin CRS22alpha-Spirost-5-en-3beta-ol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4629
ChEMBL:CHEMBL412437
EPA DTXSID:DTXSID00895074
PubMed:39536891
PubMed:39395682
PubMed:39059093
PubMed:35305976
PubMed:35149085
PubMed:34806916
PubMed:33383043
PubMed:32347045
PubMed:28106847
PubMed:26408789
PubMed:25446497
PubMed:24001619

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIOSGENIN

INCI name

DIOSGENIN

Description

(20R,25R)-spirost-5-en-3β-ol

Record provenance

Inventory reference: 83646
Imported identity: DIOSGENIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for DIOSGENIN

Annex II Restriction reference

Entry 260

Oestrogens

Key data

CAS

512-04-9

208-134-3

Restriction

II/260

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9106 · DIOSGENIN

Ingredients with overlapping formulation functions

DIOSCOREA OPPOSITIFOLIA ROOTSKIN CONDITIONING

DIOSCOREA OPPOSITIFOLIA ROOT EXTRACTSKIN CONDITIONING

DIOSCOREA POLYSTACHYA EXTRACTSKIN CONDITIONING

DIOSCOREA VILLOSA ROOT EXTRACTSKIN CONDITIONING

DIOSGENIN ARGININATESKIN CONDITIONING, SKIN PROTECTING

DIOSGENIN DIPEPTIDE-33 HCLSKIN CONDITIONING, SKIN PROTECTING

DIOSMETINSKIN CONDITIONING

DIOSPYROS EBENUM BARK EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIOSGENIN appears in the CosIng inventory

The CosIng inventory lists DIOSGENIN as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIOSGENIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIOSGENIN appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DIOSGENIN reads: "II/260". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DIOSGENIN carries the following function designation(s):

SKIN CONDITIONING

CAS 512-04-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIOSGENIN

This page combines the CosIng inventory entry for DIOSGENIN with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DIOSGENIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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