Official EU label nameGlossary entry 332

4-HYDROXYINDOLE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 8 of 13 indexed market datasets: 8 country records and 0 EU Annex records. Every result and evidence gap is listed below.

8 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:2380-94-1

EC:219-177-2

Ingredient index records:

4-HYDROXYINDOLE

Cosmetic functions: HAIR DYEING

4-hydroxyindole

Inventory restriction note: II/1220

Open full local profile

7 matched or reported names

4-HYDROXYINDOLE4-Hydroxyindole, when used as a substance in hair dye products4-Hydroxyindole, when used as a substance in hair dye4-羟基吲哚 — 4-Hydroxyindole （CAS No. 2380-94-1）4-히드록시인돌4-hidroxiindol, quando usado como substância que entra na composição de corantes capilares4-Hydroxyindole, when used as a substance in hair dye products (CAS No. 2380-94-1)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Show rows

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	No local match	0	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain GB	Prohibited	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Prohibited	1Open record 1	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Prohibited	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	Prohibited	1Open record 1	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	Review every linked record and exact conditions.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	Prohibited	1Open record 1	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Review every linked record and exact conditions.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	Prohibited	1Open record 1	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	Review every linked record and exact conditions.
India IN	Prohibited	1Open record 1	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	Review every linked record and exact conditions.
Saudi Arabia SA	Prohibited	1Open record 1	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	Review every linked record and exact conditions.

Matching market records and conditions

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

4-Hydroxyindole, when used as a substance in hair dye productsProhibited

GB Cosmetics Regulation, Annex II, entry 1220 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

4-Hydroxyindole, when used as a substance in hair dye productsProhibited

Schedule 4, reference 1220, source row 1260 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

4-Hydroxyindole, when used as a substance in hair dyeProhibited

ASEAN Annex II, reference 1220 · 2026-1

China

NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025

4-羟基吲哚 — 4-Hydroxyindole （CAS No. 2380-94-1）Prohibited

Prohibited in cosmetic product formulas. Verify the cited Chinese source identity and any later NMPA amendment before use.

NMPA 2021 Catalogue of Raw Materials Banned for Cosmetics, entry 208 · NMPA Announcement No. 74 of 2021, effective 2021-05-26

South Korea

MFDS Notice 2026-19, effective 18 March 2026

4-히드록시인돌Prohibited

화장품 안전기준 등에 관한 규정, 별표 1, record 1-1234 · 2026-19

Brazil

ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026

4-hidroxiindol, quando usado como substância que entra na composição de corantes capilaresProhibited

4-hidroxiindol, quando usado como substância que entra na composição de corantes capilares

RDC 529/2021 consolidated annex, entry 1220 (through RDC 1.030/2026) · RDC 529/2021 consolidated through RDC 1.030/2026

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

4-Hydroxyindole, when used as a substance in hair dye products (CAS No. 2380-94-1)Prohibited

Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

IS 4707 (Part 2):2025 Annex A, entry 1193 · IS 4707 (Part 2):2025, fifth revision

Saudi Arabia

SFDA live prohibited/restricted lists, snapshot 30 August 2026

4-Hydroxyindole, when used as a substance in hair dye productsProhibited

SFDA prohibited list, page 122, row 6 · live-snapshot-2026-08-30

Chemical identity and properties

PubChem 2D chemical structure for CAS 2380-94-1

CAS 2380-94-1PubChem CID 75421

1H-indol-4-ol

4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles. — ChEBI

IUPAC name: 1H-indol-4-ol

Molecular formula: C8H7NO
Molecular weight: 133.15 g/mol
Exact mass: 133.052763847 Da
XLogP3: 2.4
Topological polar surface area: 36.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

4-Hydroxyindole1W4VD9085VCHEBI:24702RefChem:99330219-177-24-IndololIndol-4-ol4-hydroxy-1h-indole

16 more reported names

UNII-1W4VD9085V4-Hydroxyindole, 99%EINECS 219-177-24-HYDROXYINDOLE [USP-RS]CCG-214548AC-5462PS-3280SR-01000944737-1Pindolol EP Impurity E4-hydroxy-indole4- HYDROXYCARBAZOLEhydroxyindoles1H-Indol-4-ol; Pindolol Imp. E (EP); Pindolol Impurity E4-Hdroxyindole4-hydroxy indole1h-indole-4-ol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:24702
ChEMBL:CHEMBL446571
EPA DTXSID:DTXSID3057696
PubMed:21438674
PubMed:20559487
PubMed:20146747
PubMed:20007669
PubMed:18341252
PubMed:17804228
PubMed:16605241
PubMed:15290130

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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