Official EU label nameGlossary entry 24180

RHEIN

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence

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Markets with evidence

Evidence gaps

Resolved identifiers

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:478-43-3

Ingredient index records:

RHEIN

Cosmetic functions: ANTIMICROBIAL

2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-,Cassic Acid,Rheic Acid

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1 matched or reported name

RHEIN

Regulatory evidence in all 13 markets

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Market	Result	Dataset	Meaning / next action
European Union EU	No local match	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain GB	No local match	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada CA	No local match	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	No local match	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN ASEAN	No local match	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China CN	No local match	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	No local match	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	No local match	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States US	No local match	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	No local match	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India IN	No local match	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia SA	No local match	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Chemical identity and properties

PubChem 2D chemical structure for CAS 478-43-3

CAS 478-43-3PubChem CID 10168

Rhein

IUPAC name: 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid

Molecular formula: C15H8O6
Molecular weight: 284.22 g/mol
Exact mass: 284.03208797 Da
XLogP3: 2.2
Topological polar surface area: 112.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

MonorheinCassic acidRhubarb YellowRheic acid4,5-Dihydroxyanthraquinone-2-carboxylic acidChrysazin-3-carboxylic acid1,8-Dihydroxyanthraquinone-3-carboxylic acid9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

16 more reported names

YM64C2P6UX2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-NSC-386291,8-dihydroxy-3-carboxyl-9,10-anthraquinoneRefChem:882948207-521-44,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid1,8-Dihydroxy-3-carboxyanthraquinoneNSC 38629C15H8O6Rhein (Standard)2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-4,5-Dihydroxy-2-anthraquinonecarboxylic acid4,5-DiOH-anthraquinone-2-COOHRhein (1,8-dihydroxy-3-carboxyl anthraquinone)9,10-Dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid

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External database identifiers

ChEBI:CHEBI:8825
ChEMBL:CHEMBL418068
EPA DTXSID:DTXSID4026000
PubMed:38723480
PubMed:37023836
PubMed:36731809
PubMed:35101544
PubMed:33438235
PubMed:31436023
PubMed:31088072
PubMed:28890383
PubMed:27633141
PubMed:26784856
PubMed:26185519
PubMed:23953579

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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