Official EU label nameGlossary entry 21249

PIROCTONE OLAMINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 5 of 13 indexed market datasets: 5 country records and 0 EU Annex records. Every result and evidence gap is listed below.

5 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:68890-66-450650-76-5

EC:272-574-2

Ingredient index records:

PIROCTONE OLAMINE

Cosmetic functions: ANTI-SEBORRHEIC, PRESERVATIVE

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

Inventory restriction note: III/61 V/35

Open full local profile

7 matched or reported names

PIROCTONE OLAMINEpiroctone olamine1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, Piroctone Olamine1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)2-pyridon (piroctone olamine), and its monoethanolamine salt1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon (CAS No. 50650-76-5), piroctone Olamine (CAS No. 68890-66-4)Piroctone olamine피록톤올아민(1-하이드록시-4-메칠-6(2,4,4-트리메칠펜틸)2-피리돈 및그 모노에탄올아민염)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Show rows

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Market	Result	Records	Dataset	Meaning / next action
European Union EU	No local match	0	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain GB	Permitted list with conditions	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Permitted list with conditions	1Open record 1	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Permitted list with conditions	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	No local match	0	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	Restricted	1Open record 1	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	Review every linked record and exact conditions.
South Korea KR	Restricted	1Open record 1	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Review every linked record and exact conditions.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	No local match	0	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India IN	No local match	0	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia SA	No local match	0	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Matching market records and conditions

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, Piroctone OlaminePermitted list with conditions

Rinse-off products · 1,0%

GB Cosmetics Regulation, Annex V, entry 35 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)2-pyridon (piroctone olamine), and its monoethanolamine saltPermitted list with conditions

Product scope: (a) Rinse-off products (b) Other products · Maximum concentration: (a) 1.0% (b) 0.5%

Schedule 7, reference 35, source row 98 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon (CAS No. 50650-76-5), piroctone Olamine (CAS No. 68890-66-4)Permitted list with conditions

1% 0.5% · Rinse-off products For other products

ASEAN Annex VI, reference 35 · 2026-1

Japan

MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot

Piroctone olamineRestricted

Published three-column use matrix (rinse-off / leave-on / mucosal; blank means prohibited, ○ means no upper limit): 0.05 0.05

Appendix 3 section 2, entry 25 · MHLW Notification No. 331 provisional translation, retrieved 2026-08-30

South Korea

MFDS Notice 2026-19, effective 18 March 2026

피록톤올아민(1-하이드록시-4-메칠-6(2,4,4-트리메칠펜틸)2-피리돈 및그 모노에탄올아민염)Restricted

사용 후 씻어내는 제품에 1.0%, 기타 제품에 0.5%

화장품 안전기준 등에 관한 규정, 별표 2, record 2-114 · 2026-19

Chemical identity and properties

PubChem 2D chemical structure for CAS 50650-76-5

CAS 50650-76-5PubChem CID 50259

Piroctone

Piroctone is a cyclic hydroxamic acid that consists of 1-hydroxypyridin-2-one bearing methyl and 2,4,4-trimethylpentyl substtituents at positions 4 and 6 respectively. It has a role as an antiseborrheic. It is a cyclic hydroxamic acid, a pyridone and a hydroxypyridone antifungal drug. — ChEBI

IUPAC name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one

Molecular formula: C14H23NO2
Molecular weight: 237.34 g/mol
Exact mass: 237.172878976 Da
XLogP3: 3.1
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

PiroctonaPiroctonumPiroctonolPiroctonum [INN-Latin]1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridoneUNII-R49EFA73Q7R49EFA73Q7Piroctona [INN-Spanish]

16 more reported names

CHEBI:590091-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-onePiroctonum (INN-Latin)Piroctona (INN-Spanish)1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)-2-pyridoneRefChem:578312(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-Piroctone [USAN]Piroctone [USAN:INN]PIROCTONE [INN]PIROCTONE [MI]Piroctone (USAN/INN)PIROCTONE [WHO-DD]SCHEMBL3588AB01563386_01BRD-A96510685-213-01-1

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:59009
ChEMBL:CHEMBL1473700
EPA DTXSID:DTXSID2048298
PubMed:22678620
PubMed:21987135
PubMed:21282741
PubMed:21272039
PubMed:20546226
PubMed:19626976
PubMed:18498517
PubMed:18494909
PubMed:18269596
PubMed:16681805
PubMed:16329615
PubMed:16149717

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 68890-66-4

CAS 68890-66-4PubChem CID 50258

Piroctone Olamine

IUPAC name: 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one

Molecular formula: C16H30N2O3
Molecular weight: 298.42 g/mol
Exact mass: 298.22564282 Da
Topological polar surface area: 86.8 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

OctopiroxOctopyroxPiroctone ethanolaminePiroctone ethanolamine saltAllermylA4V5C6R9FBNSC-759894PIROCTONE ETHANOLAMINE SALT (1:1)

16 more reported names

CHEBI:59008FORTE Magnetic S3 Oil Control Anti-DandfuffKeratoluxRefChem:57832GZE Black Castor Oil EdgeControl272-574-2KopiroxPiroctoneolaminePiroctone olamine [USAN]Octopirox (TN)Piroctone olamine (USAN)1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol saltPiroctone olamine, United States Pharmacopeia (USP) Reference Standard1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)EINECS 272-574-2

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL2107154
PubMed:21272039
PubMed:1545

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision