What does the restriction note for PIROCTONE OLAMINE mean?

The restriction field for PIROCTONE OLAMINE reads: III/61 V/35. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 68890-66-4?

CAS 68890-66-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains PIROCTONE OLAMINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3660410/08/2020

PIROCTONE OLAMINE

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

PIROCTONE OLAMINE is linked to 2 EU annex records on this page. Inventory note: III/61 V/35.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	2	English and EU languages
Great Britain	Evidence linked Permitted list with conditions Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Permitted list with conditions Open this evidence	1	English
ASEAN	Evidence linked Permitted list with conditions Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Evidence linked Restricted Open this evidence	1	Japanese; official English translation available
South Korea	Evidence linked Restricted Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 68890-66-4

CAS 68890-66-4PubChem CID 50258

Piroctone Olamine

IUPAC name: 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one

Molecular formula: C16H30N2O3
Molecular weight: 298.42 g/mol
Exact mass: 298.22564282 Da
Topological polar surface area: 86.8 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

OctopiroxOctopyroxPiroctone ethanolaminePiroctone ethanolamine saltAllermylA4V5C6R9FBNSC-759894PIROCTONE ETHANOLAMINE SALT (1:1)

16 more reported names

CHEBI:59008FORTE Magnetic S3 Oil Control Anti-DandfuffKeratoluxRefChem:57832GZE Black Castor Oil EdgeControl272-574-2KopiroxPiroctoneolaminePiroctone olamine [USAN]Octopirox (TN)Piroctone olamine (USAN)1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol saltPiroctone olamine, United States Pharmacopeia (USP) Reference Standard1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1)EINECS 272-574-2

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL2107154
PubMed:21272039
PubMed:1545

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PIROCTONE OLAMINE

INCI name

PIROCTONE OLAMINE

INN name

piroctone olamine

Description

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)

Record provenance

Inventory reference: 36604
Imported identity: PIROCTONE OLAMINE
Source update: 10/08/2020

European Commission CosIng source notes

Annex records for PIROCTONE OLAMINE

Annex III Restriction reference

Entry 61

Monoalkylamines, monoalkanolamines and their salts

Annex V Restriction reference

Entry 35

1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon, piroctone olamine

CAS: 50650-76-5 / 68890-66-4

EC: - / 272-574-2

Key data

CAS

68890-66-4

272-574-2

Restriction

III/61 V/35

Function

ANTI-SEBORRHEIC: Preventing or relieving the symptoms of seborrhea and/or seborrheic dermatitis, including dandruff.
PRESERVATIVE: Exclusively or mainly intended to inhibit the development of micro-organisms in the cosmetic product. All authorised preservatives are substances in the positive list of Annex V to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#21249 · PIROCTONE OLAMINE

The 6 markets that hold a rule for this substance do not classify it the same way.

restricted: European Union Japan South Korea
permitted on a positive list: Great Britain New Zealand ASEAN

See every substance the markets disagree about

Ingredients with overlapping formulation functions

PICEA ABIES LEAF EXTRACTANTI-SEBORRHEIC

PINUS DENSIFLORA LEAF/SUGAR FERMENT FILTRATEANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT, ORAL CARE, SKIN CONDITIONING

PINUS PINASTER BARK/BUD EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT, ORAL CARE, SKIN CONDITIONING, UV ABSORBER

PINUS SYLVESTRIS TRUNK EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIPERSPIRANT, ORAL CARE

PISTACIA LENTISCUS GUM OILANTI-SEBORRHEIC, ANTIMICROBIAL, PERFUMING

PISTACIA LENTISCUS GUM WATERANTI-SEBORRHEIC, ANTIMICROBIAL, PERFUMING

POGOSTEMON CABLIN LEAF/STEM EXTRACTANTI-SEBORRHEIC, ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, SKIN PROTECTING

POMEGRANATE FRUIT PEEL EXTRACT OCTENYLSUCCINATEANTI-SEBORRHEIC

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PIROCTONE OLAMINE appears in the CosIng inventory

The CosIng inventory lists PIROCTONE OLAMINE as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PIROCTONE OLAMINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PIROCTONE OLAMINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for PIROCTONE OLAMINE reads: "III/61 V/35". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, PIROCTONE OLAMINE carries the following function designation(s):

CAS 68890-66-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PIROCTONE OLAMINE

This page combines the CosIng inventory entry for PIROCTONE OLAMINE with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research PIROCTONE OLAMINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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