Why does CAS 90-69-7 appear in more than one EU cosmetic annex?

A substance identified by CAS 90-69-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 90-69-7?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 90-69-7 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 90-69-7

Q: How do I use CAS 90-69-7 for compliance screening?

Cross-reference CAS 90-69-7 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 90-69-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 90-69-7

CAS 90-69-7PubChem CID 101616

Lobeline

(-)-lobeline is an optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position. It has a role as a nicotinic acetylcholine receptor agonist. It is a piperidine alkaloid, a tertiary amine and an aromatic ketone. — ChEBI

IUPAC name: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone

Molecular formula: C22H27NO2
Molecular weight: 337.5 g/mol
Exact mass: 337.204179104 Da
XLogP3: 3.8
Topological polar surface area: 40.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 3

Also known as

(-)-LobelineInflatinealpha-LobelineLobnicoLobelinumLobelinLobelina8,10-Diphenyllobelionol

16 more reported names

D0P25S3P812-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenoneNSC-7574212-{(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl}-1-phenylethanoneCHEBI:48723Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, (2R-(2alpha,6alpha(S*)))-2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone2-[6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl]-1-phenylethanone2-((2R,6S)-6-((2S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanoneRefChem:153874202-012-3Lobeline [INN].alpha.-LobelineLobeline (INN)2-((2R,6S)-6-((S)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:48723
ChEMBL:CHEMBL122270
EPA DTXSID:DTXSID3023219
PubMed:39136667
PubMed:22243960
PubMed:21580177
PubMed:21580176
PubMed:20410102
PubMed:19217305
PubMed:18798630
PubMed:17585846
PubMed:17368966
PubMed:16825297
PubMed:15549833
PubMed:12126489

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 90-69-7

1 total

Annex

Entry

219

Lobeline (INN) and its salts

202-012-3

How CAS 90-69-7 is used on this site

CAS 90-69-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 90-69-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 90-69-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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