Why does CAS 757-58-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 757-58-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 757-58-4?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 757-58-4 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 757-58-4

Q: How do I use CAS 757-58-4 for compliance screening?

Cross-reference CAS 757-58-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 757-58-4 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 757-58-4

CAS 757-58-4PubChem CID 12960

Hexaethyltetraphosphate

Hexaethyl tetraphosphate is a yellow liquid which is miscible in water. It is difficult to burn. It is toxic by skin absorption and inhalation. It is a mixture of ethyl phosphates and ethyl pyrophosphate. It decomposes at high temperatures. May be found in the form of a dry mixture where the liquid is absorbed onto a dry carrier. — CAMEO Chemicals

IUPAC name: diethoxyphosphoryl [diethoxyphosphoryloxy(ethoxy)phosphoryl] ethyl phosphate

Molecular formula: C12H30O13P4
Molecular weight: 506.25 g/mol
Exact mass: 506.06368900 Da
XLogP3: 0.0
Topological polar surface area: 151.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 13
Covalent units: 1
Defined stereocentres: 0

Also known as

Hexaethyl tetraphosphateEthyl tetraphosphateBladan baseHexaethyltetrafosfatRCRA waste number P062Ethyl tetraphosphate, hexa-Hexaethyltetrafosfat [Czech]Tetraphosphoric acid, hexaethyl ester

16 more reported names

HSDB 558YL9WI50HOGTetraphosphate hexaethyliqueEINECS 212-057-0Tetraphosphate hexaethylique [French]UN1611UN1612BRN 1718039AI3-14079HEXAETHYLTETRAPHOSPHATE [HSDB]RefChem:786076Ethyl tetraphosphate, hexa212-057-0HETPUNII-YL9WI50HOGRCRA waste no. P062

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID80862401
PubMed:22163587
PubMed:20718963

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 757-58-4

1 total

Annex

Entry

316

Hexaethyl tetraphosphate

212-057-0

How CAS 757-58-4 is used on this site

CAS 757-58-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 757-58-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 757-58-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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