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Annex II Entry 316 15/10/2010

Hexaethyl tetraphosphate

Hexaethyl tetraphosphate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 316

Chemical identity and properties

PubChem 2D chemical structure for CAS 757-58-4
CAS 757-58-4PubChem CID 12960

Hexaethyltetraphosphate

Hexaethyl tetraphosphate is a yellow liquid which is miscible in water. It is difficult to burn. It is toxic by skin absorption and inhalation. It is a mixture of ethyl phosphates and ethyl pyrophosphate. It decomposes at high temperatures. May be found in the form of a dry mixture where the liquid is absorbed onto a dry carrier. — CAMEO Chemicals

IUPAC name
diethoxyphosphoryl [diethoxyphosphoryloxy(ethoxy)phosphoryl] ethyl phosphate
Molecular formula
C12H30O13P4
Molecular weight
506.25 g/mol
Exact mass
506.06368900 Da
XLogP3
0.0
Topological polar surface area
151.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
13
Covalent units
1
Defined stereocentres
0

Also known as

Hexaethyl tetraphosphateEthyl tetraphosphateBladan baseHexaethyltetrafosfatRCRA waste number P062Ethyl tetraphosphate, hexa-Hexaethyltetrafosfat [Czech]Tetraphosphoric acid, hexaethyl ester
16 more reported names
HSDB 558YL9WI50HOGTetraphosphate hexaethyliqueEINECS 212-057-0Tetraphosphate hexaethylique [French]UN1611UN1612BRN 1718039AI3-14079HEXAETHYLTETRAPHOSPHATE [HSDB]RefChem:786076Ethyl tetraphosphate, hexa212-057-0HETPUNII-YL9WI50HOGRCRA waste no. P062
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Hexaethyl tetraphosphate

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
757-58-4
EC
212-057-0
Annex
II
Entry number
316

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 310
Nearby record in the same annex

Thiotepa (INN)

CAS: 52-24-4
EC: 200-135-7

What Annex II means for Hexaethyl tetraphosphate

Hexaethyl tetraphosphate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Hexaethyl tetraphosphate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 757-58-4 is the unique numerical identifier assigned to Hexaethyl tetraphosphate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Hexaethyl tetraphosphate

This page summarizes one Annex II record for Hexaethyl tetraphosphate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Hexaethyl tetraphosphate, but confirm any final regulatory decision against the current official annex wording and source files.

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