Skip to main content
CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
CAS 1 record

CAS 116-14-3

CAS 116-14-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS numberBrowse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 116-14-3
CAS 116-14-3PubChem CID 8301

Tetrafluoroethylene

Tetrafluoroethene is a fluorocarbon. — ChEBI

IUPAC name
1,1,2,2-tetrafluoroethene
Molecular formula
C2F4
Molecular weight
100.01 g/mol
Exact mass
99.99361265 Da
XLogP3
1.3
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

TetrafluoroethenePerfluoroethylenePerfluoroetheneFluoroplast 41,1,2,2-TetrafluoroethyleneEthene, tetrafluoro-Ethylene, tetrafluoro-Tetrafluoroethylene monomer
16 more reported names
TetrafluorethyleneOMW63Z518SCHEBI:38866ethylene tetrafluorideRefChem:6295204-126-9NSC451C2F4PerfluoraethylenTetrafluoraethenTetrafluoraethylenF2C=CF2Polytetrafluoroethylene preparationEthene, 1,1,2,2-tetrafluoro-TetrafluoretheneFluoropolymer, Fluorinated polymer, PTFE
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8301

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: CAUTION: Exposure of skin to compressed gases may result in freezing of the skin. Treatment for frostbite may be necessary. Remove the victim from the source of contamination. IMMEDIATELY wash affected areas gently with COLD water (and soap, if necessary) while removing and isolating all contaminated clothing. Dry carefully with clean, soft towels. If symptoms such as inflammation or irritation develop, IMMEDIATELY call a physician or go to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a ho Source: CAMEO Chemicals
  • ERG2024, Guide 116P (Tetrafluoroethylene, stabilized): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 59.3% (481 of 811) of all reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H220 (30.7%): Extremely flammable gas [Danger Flammable gases]; H280 (36.6%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H350 (36%): May cause cancer [Danger Carcinogenicity]; H371 (32.2%): May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P222, P260, P264, P270, P280, P308+P316, P318, P377, P381, P403, P405, P410+P403, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 811 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 481 of 811 reports by companies.; There are 11 notifications provided by 330 of 811 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H220: Extremely flammable gas [Danger Flammable gases]; H231: May react explosively even in the absence of air at elevated pressure and/or temperature [Danger Flammable gases]; H280: Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 3 - Materials that in themselves are capable of detonation or explosive decomposition or explosive reaction but that require a strong initiating source or must be heated under confinement before initiation. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for tetrafluoroethylene(SRC), using an estimated/ log Kow of 1.21(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 95(SRC), determined from a structure estimation method(2), indicates that tetrafluoroethylene is expected to have high mobility in soil(SRC). Volatilization of tetrafluoroethylene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.63 atm-cu m/mole(SRC), based upon its vapor pressure, 2.45X10+4 mm Hg(3), and water solubility, 159 mg/L(4). Tetrafluoroethylene is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation data were not available(SRC, 2010). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 95(SRC), determined from a structure estimation method(2), indicates that tetrafluoroethylene is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.63 atm-cu m/mole(SRC), derived from its vapor pressure, 2.45X10+4 mm Hg(4), and water solubility, 159 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3 hours and 4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of 1.21(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2010). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetrafluoroethylene, which has a vapor pressure of 2.45X10+4 mm Hg at 25 °C(2), is expected to exist solely as a gas in the ambient atmosphere. Gas-phase tetrafluoroethylene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hours(SRC), calculated from its rate constant of 1.13X10-11 cu cm/molecule-sec at 298 K(3). Gas-phase tetrafluoroethylene will be degraded in the atmosphere by reaction with ozone(3,4) and nitrate radicals(3). The rate constant for the vapor-phase reaction of tetrafluoroethylene with photochemically-produced hydroxyl radicals has been estimated as 1.13X10-11 cu cm/molecule-sec at 298 K(1). The rate constant for the vapor-phase reaction of tetrafluoroethylene with ozone has been reported as 4.8X10-21 cu cm/molecule-sec at 298 K(1). The Global Warming Potential is considered to be negligible(5). Tetrafluoroethylene does not contain chromophores that absorb at wavelengths >290 nm(6), and therefore is not expected to be susceptible to dire Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used to produce polytetrafluoroethylene polymers (Teflon); [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: In prepn of propellants for food product aerosols Source: Hazardous Substances Data Bank (HSDB)
  • Uses: MONOMER FOR POLYTETRAFLUOETHYLENE RESINS; CHEM INT FOR HEXAFLUOROPROPYLENE; COMONOMER FOR PERFLUOROALKOXY RESINS, FLUORINATED ETHYLENE-PROPYLENE RESINS, & ETHYLENE-TETRAFLUOROETHYLENE RESINS; TERMONOMER WITH VINYLIDENE FLUORIDE & HEXAFLUOROPROPYLENE Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as a copolymer with hexafluoropropylene to substitute for polytetrafluoroethylene Source: Hazardous Substances Data Bank (HSDB)
  • Uses: It is used mainly for the production of fluoropolymers. It reacts with perfluoronitrosoalkanes to produce so-called nitroso rubbers. It is also used in the production of low molecular mass compounds and intermediates, for example, for the manufacture of iodoperfluoroalkanes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Principal industrial use of CF2:CF2 is for preparation of polytetrafluoroethylene (Teflon (R)) Resins and copolymers. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: • Manufacture of chemicals and chemical products [Ref: http://www.spin2000.net/spinmyphp/]; • Coating for fishing lines [Ref: CAS2019 (JP01160443)]; • Construction [Ref: http://www.spin2000.net/spinmyphp/]; • Manufacture of radio, television and communication equipment [Ref: http://www.spin2000.net/spinmyphp/]; • Lubricants and additives [Ref: http://www.spin2000.net/spinmyphp/]; • Inert surface in UPLCs [Ref: https://doi.org/10.1039/C9EM00163H]; • Use in lithium batteries [Ref: Kountz, Dennis J., James R. Hoover, and George Martin Pruce. 2015. Li-Ion battery having improved safety agains combustion. EP 2 891 196 B1, issued 2015.]; • Floor polish [Ref: http://www.spin2000.net/spinmyphp/]; • Cosmetics (bronzer, blush, eye shadow, shaving cream (men's), foundation, mascara, facial powder, eye liner, mascara, sunscreen, sunscreen lip balm, sunscreen makeup, anti-aging, oil controller, eye cream, brow liner, concealer) [Ref: Brinch2018, GSP2014]; • Use in printed circuit boards [Ref: CAS2019 (US20030203174)]; • Architechtural membranes [Ref: https://www.bdir.com/projects/tensile-pvdf-membrane-roof-structures-tent-hotel-resort-guizhou-china]; • Reinforcement of fluorinated membranes [Re Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 116-14-3

1 total

How CAS 116-14-3 is used on this site

CAS 116-14-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 116-14-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 116-14-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.
Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 116-14-3 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 116-14-3 in your documentation.

Search