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Annex IV Entry 99 14/08/2020

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

CI 73015

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate appears in Annex IV as a positive-list colorant entry for EU cosmetics.

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Permitted colorant— Annex IV, EU Regulation 1223/2009
Entry: 99

Chemical identity and properties

PubChem 2D chemical structure for CAS 860-22-0
CAS 860-22-0PubChem CID 2723854

Indigo carmine

Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow. It has a role as a two-colour indicator, a histological dye and a food colouring. It contains an indigo carmine(2-). — ChEBI

IUPAC name
disodium;2-(3-hydroxy-5-sulfonato-1H-indol-2-yl)-3-oxoindole-5-sulfonate
Molecular formula
C16H8N2Na2O8S2
Molecular weight
466.4 g/mol
Exact mass
465.95174613 Da
Topological polar surface area
197.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
9
Covalent units
3
Defined stereocentres
0

Also known as

Acid Blue 74Indigotindisulfonate sodiumIndigotineindigocarmineC.I. ACID BLUE 74Sodium 3,3'-dioxo-[2,2'-biindolinylidene]-5,5'-disulfonateIndigocarminC.I. Food Blue 1
16 more reported names
FD&C Blue No. 2Food Blue No. 2FD & C blue no. 2FD and C Blue No. 2SachsischblauMurabbaAmacid Brilliant BlueIndigotine LakeIndocarmine FSoluble IndigoDisodium 5,5'-disulfoindigoIndigotine BIndigotine IIndigotine NIntense BlueIndigotin I
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Warnings

Purity criteria as set out in Commission Directive 95/45/EC (E 132)

Colour index or glossary

CI 73015

Chemical name

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

Chemical / IUPAC name

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

Color

Blue

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
860-22-0
EC
212-728-8
Annex
IV
Entry number
99

Inventory links for Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

Inventory Restriction reference
Ref 31612

ACID BLUE 74

CAS: 860-22-0
EC: 212-728-8
Inventory Restriction reference
Ref 32793

CI 73015

CAS: 860-22-0
EC: 212-728-8

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What Annex IV means for Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm colorant is used only in permitted product types listed above.
  • Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 860-22-0 is the unique numerical identifier assigned to Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex IV record Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

This page summarizes one Annex IV record for Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate, but confirm any final regulatory decision against the current official annex wording and source files.

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