Why does CAS 860-22-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 860-22-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 860-22-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 860-22-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 860-22-0

Q: How do I use CAS 860-22-0 for compliance screening?

Cross-reference CAS 860-22-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 860-22-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 860-22-0

CAS 860-22-0PubChem CID 2723854

Indigo carmine

Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. It is an indicator at pH 11.5-14, changing from blue to yellow. It has a role as a two-colour indicator, a histological dye and a food colouring. It contains an indigo carmine(2-). — ChEBI

IUPAC name: disodium;2-(3-hydroxy-5-sulfonato-1H-indol-2-yl)-3-oxoindole-5-sulfonate

Molecular formula: C16H8N2Na2O8S2
Molecular weight: 466.4 g/mol
Exact mass: 465.95174613 Da
Topological polar surface area: 197.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 9
Covalent units: 3
Defined stereocentres: 0

Also known as

Acid Blue 74Indigotindisulfonate sodiumIndigotineindigocarmineC.I. ACID BLUE 74Sodium 3,3'-dioxo-[2,2'-biindolinylidene]-5,5'-disulfonateIndigocarminC.I. Food Blue 1

16 more reported names

FD&C Blue No. 2Food Blue No. 2FD & C blue no. 2FD and C Blue No. 2SachsischblauMurabbaAmacid Brilliant BlueIndigotine LakeIndocarmine FSoluble IndigoDisodium 5,5'-disulfoindigoIndigotine BIndigotine IIndigotine NIntense BlueIndigotin I

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31695
ChEMBL:CHEMBL2105023
EPA DTXSID:DTXSID1020190

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 860-22-0

1 total

Annex

Entry

CI 73015

Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate

Purity criteria as set out in Commission Directive 95/45/EC (E 132)

212-728-8

How CAS 860-22-0 is used on this site

CAS 860-22-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 860-22-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 860-22-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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