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Annex IV Entry 44 13/08/2020

Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

CI 19140

Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments appears in Annex IV as a positive-list colorant entry for EU cosmetics.

Permitted colorant— Annex IV, EU Regulation 1223/2009
Entry: 44

Chemical identity and properties

PubChem 2D chemical structure for CAS 12225-21-7
CAS 12225-21-7PubChem CID 22833487

C.I. Pigment Yellow 100

C.I. Pigment Yellow 100 is an organonitrogen compound and an organooxygen compound. It is functionally related to an alpha-amino acid. ChEBI

IUPAC name
aluminum tris(4-[[3-carboxy-5-oxo-1-(4-sulfophenyl)-4H-pyrazol-4-yl]diazenyl]benzenesulfonate)
Molecular formula
C48H33AlN12O27S6
Molecular weight
1429.2 g/mol
Exact mass
1427.9717743 Da
Topological polar surface area
669.0 Ų
Hydrogen-bond donors
6
Hydrogen-bond acceptors
36
Covalent units
4
Defined stereocentres
0

Also known as

YELLOW LAKE TRefChem:572571JAPAN YELLOW 4 ALUMINUM LAKEFD AND C YELLOW NO. 5 ALUMINUM LAKE4,5-DIHYDRO-5-OXO-1-(4-SULFOPHENYL)-4-((4-SULFOPHENYL)AZO)-1H-PYRAZOLE-3-CARBOXYLIC ACID ALUMINUM COMPLEXaluminum;4-[[3-carboxy-5-oxo-1-(4-sulfophenyl)-4H-pyrazol-4-yl]diazenyl]benzenesulfonateCHEBI:189920CID 22833487
2 more reported names
aluminum;4-[[3-carboxy-5-oxo-1-(4-sulophenyl)-4H-pyrazol-4-yl]diazenyl]benzenesulonateAluminium tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzene-1-sulfonate)
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match22833487

Attributed physical-property, hazard, environmental and use annotations.

  • Solubility: less than 1 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 100% (503 of 503) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 503 of 503 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 503 reports by companies from 1 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 503 of 503 reports by companies.; There are 0 notifications provided by 0 of 503 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 1934-21-0
CAS 1934-21-0PubChem CID 164825

Tartrazine

Tartrazine is an organic sodium salt which is the trisodium salt of tartrazine acid. A synthetic lemon yellow azo dye used as a food colouring. It has a role as a histological dye and a food colouring. It contains a tartrazine(3-). ChEBI

IUPAC name
trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4H-pyrazole-3-carboxylate
Molecular formula
C16H9N4Na3O9S2
Molecular weight
534.4 g/mol
Exact mass
533.95040307 Da
Topological polar surface area
229.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
12
Covalent units
4
Defined stereocentres
0

Also known as

Yellow 5Food Yellow 4Aizen tartrazineTartraphenineTartran YellowAmacid Yellow TCilefa Yellow T1342-47-8
16 more reported names
FD&C Yellow No. 5A.F. Yellow No. 4FD & C Yellow no. 5C.I. 19140Tartrazine FD&C Yellow #5Atul TartrazineErio TartrazineKako TartrazineTartrazine LakeTartrazine BTartrazine CTartrazine GTartrazine MTartrazine NTartrazine OTartrazine T
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Warnings

Purity criteria as set out in Commission Directive 95/45/EC (E 102)

Colour index or glossary

CI 19140

Chemical name

Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Chemical / IUPAC name

Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Color

Yellow

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
12225-21-7; 1934-21-0
EC
235-428-9; 217-699-5
Annex
Entry number
44

Inventory links for Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Inventory Restriction reference
Ref 31637

ACID YELLOW 23

CAS: 1934-21-0
EC: 217-699-5
Inventory Restriction reference
Ref 32737

CI 19140

CAS: 1934-21-0
EC: 217-699-5

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex IV 43
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CI 18690

CAS: 5601-29-6
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CI 21108

CAS: 5567-15-7
EC: 226-939-8
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CI 18130

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EC: 223-098-9

What Annex IV means for Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 3 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm colorant is used only in permitted product types listed above.
  • Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 12225-21-7; 1934-21-0 is the unique numerical identifier assigned to Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Source note for Annex IV record Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments

This page summarizes one Annex IV record for Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for Trisodium 5-hydroxy-1-(4-sulphophenyl)-4-((4-sulphophenyl)azo)pyrazole-3-carboxylate and its insoluble barium, strontium and zirconium lakes, salts and pigments, but confirm any final regulatory decision against the current official annex wording and source files.

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