What is CAS 1308-38-9 for Chromium (III) oxide?

CAS 1308-38-9 is the unique numerical identifier assigned to Chromium (III) oxide by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex IV Entry 129 14/08/2020

Chromium (III) oxide

Q: How do I check if my product formula contains Chromium (III) oxide?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

CI 77288

Chromium (III) oxide appears in Annex IV as a positive-list colorant entry for EU cosmetics.

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Permitted colorant— Annex IV, EU Regulation 1223/2009

Entry: 129

Chemical identity and properties

PubChem 2D chemical structure for CAS 1308-38-9

CAS 1308-38-9PubChem CID 517277

Chromia

Dichromium trioxide is a chromium oxide. — ChEBI

IUPAC name: oxo(oxochromiooxy)chromium

Molecular formula: Cr2O3
Molecular weight: 151.990 g/mol
Exact mass: 151.865753 Da
Topological polar surface area: 43.4 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Chromium(III) oxideDichromium trioxideCHROMIC OXIDEChrome oxideChrome GreenGreen chromium oxideGreen cinnabarChrome ochre

16 more reported names

Chromium Oxide GreenAnadonis GreenCasalis GreenGreen rougeChrome OcherLeaf greenChromium(3+) oxideLevanox green gachromium (III) oxideOxide of chromiumGreen oxide of chromiumGreen chrome oxideChromic Acid GreenGreen chromic oxideChrome Green F 3Chromium oxide (Cr2O3)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:48242
EPA DTXSID:DTXSID4043721
PubMed:26086747
PubMed:24885771
PubMed:21384495
PubMed:15003702
PubMed:12634122
PubMed:1423875

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match517277

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 4000 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 4000 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Color/Form: Light to dark green, fine, hexagonal crystals Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Green powder Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Bright-green, extremely hard crystals Source: Hazardous Substances Data Bank (HSDB)

Density: 5.22 at 25 °C Source: Hazardous Substances Data Bank (HSDB)
Density: 5.22 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 5.22 @25 °C Source: PAC Chemical Database, U.S. Department of Energy

Melting Point: 2435 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 2435 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Melting Point: 2320 °C Source: PAC Chemical Database, U.S. Department of Energy

Physical Description: Dry Powder; Large Crystals; Dry Powder; Large Crystals; Liquid; Other Solid; Dry Powder; CBI; Large Crystals Source: EPA Chemical Data Reporting (CDR)
Physical Description: Green, hygroscopic solid; [CHEMINFO] Insoluble in water; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: LIGHT-TO-DARK-GREEN POWDER. Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Refractive Index: Index of refraction: 2.551 Source: Hazardous Substances Data Bank (HSDB)

Solubility: In water, 3.13 ug/L at 20 °C, pH 6; 2.96 ug/L at 20 °C, pH 8 Source: Hazardous Substances Data Bank (HSDB)
Solubility: Practically insoluble in water Source: Hazardous Substances Data Bank (HSDB)
Solubility: Practically insoluble in alcohol, acetone; slightly soluble in acids, alkalies Source: Hazardous Substances Data Bank (HSDB)
Solubility: Insoluble in acids, and alkalies Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water: none Source: ILO-WHO International Chemical Safety Cards (ICSCs)

pH: Trivalent chromium compounds are amphoteric Source: Hazardous Substances Data Bank (HSDB)

Carcinogen Classification: 3, not classifiable as to its carcinogenicity to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: Oral (L16) ; inhalation (L16) ; dermal (L16) Source: Toxin and Toxin Target Database (T3DB)

Note: This chemical does not meet GHS hazard criteria for 57.8% (1112 of 1924) of all reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (24%): Harmful if swallowed [Warning Acute toxicity, oral]; H317 (25.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (24.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H360 (14.6%): May damage fertility or the unborn child [Danger Reproductive toxicity] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P261, P264, P264+P265, P270, P272, P280, P301+P317, P302+P352, P305+P351+P338, P318, P321, P330, P333+P317, P337+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1924 reports by companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1112 of 1924 reports by companies.; There are 23 notifications provided by 812 of 1924 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P233, P260, P261, P264, P270, P271, P272, P280, P284, P302+P352, P304+P340, P319, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory] Source: NITE-CMC
Precautionary Statement Codes: P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement) Source: NITE-CMC

Health Effects: Chromium in its trivalent state is not very toxic. It may be oxidized to hexavalent chromium, a known carcinogen. Hexavalent chromium has also been shown to affect reproduction and development. (A12) Source: Toxin and Toxin Target Database (T3DB)

Toxicity Summary: IDENTIFICATION AND USE: Chromic oxide (Cr(2)O(3)) is a green powder. It is not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. It is used in abrasives and electric semiconductors; in alloys; in printing fabrics and banknotes. It is also used in dyeing polymers; colorant for latex paints, in manufacturing of chromium metal and aluminum-chromium master alloys. It's other uses include catalyst in organic synthesis, green granules in asphalt roofing, component of refractory brick. Chromic oxide is a color additive in drug use. HUMAN EXPOSURE AND TOXICITY: Fine chromic oxide particles were insoluble in the culture medium; on the contrary, Cr(2)O(3) nanoparticles released soluble hexavalent chromium into the culture medium. Human lung carcinoma A549 cells and human keratinocyte HaCaT cells showed an increase in intracellular reactive oxygen species (ROS) level and activation of antioxidant defense systems on exposure to Cr(2)O(3) nanoparticles. The cellular influences of Cr(2)O(3) nanoparticles matched those of hexavalent chromium. Human lung epithelial c Source: Hazardous Substances Data Bank (HSDB)
Toxicity Summary: Trivalent chromium may also form complexes with peptides, proteins, and DNA, resulting in DNA-protein crosslinks, DNA strand breaks, DNA-DNA interstrand crosslinks, chromium-DNA adducts, chromosomal aberrations and alterations in cellular signaling pathways. It has been shown to induce carcinogenesis by overstimulating cellular regulatory pathways and increasing peroxide levels by activating certain mitogen-activated protein kinases. It can also cause transcriptional repression by cross-linking histone deacetylase 1-DNA methyltransferase 1 complexes to CYP1A1 promoter chromatin, inhibiting histone modification. Chromium may increase its own toxicity by modifying metal regulatory transcription factor 1, causing the inhibition of zinc-induced metallothionein transcription. (A12, L16, A34, A35, A36) Source: Toxin and Toxin Target Database (T3DB)

Consumer Uses: Other; Processing aids not otherwise specified; Catalyst; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Pigment Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Abrasives; Other; Pigment; Dye; Catalyst; Not Known or Reasonably Ascertainable; Corrosion inhibitor Source: EPA Chemical Data Reporting (CDR)

Sources/Uses: Used in abrasives, refractory materials, semiconductors, pigments, alloys, textile printing inks, and catalysts; [Merck Index] Used as a pigment in polymers and latex paints; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For chromic oxide (USEPA/OPP Pesticide Code: 021103) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: In abrasives, refractory materials, electric semiconductors; as pigment, particularly in coloring glass; in alloys; in printing fabrics and banknotes; catalyst for organic and inorganic reactions. Source: Hazardous Substances Data Bank (HSDB)
Uses: Used in dyeing polymers, ... colorant for latex paints. Source: Hazardous Substances Data Bank (HSDB)
Uses: In metallurgy in the manufacture of chromium metal and aluminum-chromium master alloys. Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for Chromium (III) oxide (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Uses: Plastics -> Typical concentration range in plastic materials -> 1% Source: NORMAN Suspect List Exchange
Uses: Chromium(III) oxide is commonly used as pigment, under the name viridian, in paints, inks, and glasses. (L523) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Warnings

free from chromate ion

Colour index or glossary

CI 77288

Chemical name

Chromium (III) oxide

Chemical / IUPAC name

Chromium (III) oxide

Color

Green

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

CI 77288

Key data

CAS

1308-38-9

215-160-9

Annex

Entry number

129

Inventory links for Chromium (III) oxide

Inventory Restriction reference

Ref 32823

CI 77288

CAS: 1308-38-9

EC: 215-160-9

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex IV 128