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Annex II Entry 84 17/10/2010

Chlorprothixene (INN) and its salts

Chlorprothixene (INN) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 84

Chemical identity and properties

PubChem 2D chemical structure for CAS 113-59-7
CAS 113-59-7PubChem CID 667467

Chlorprothixene

(Z)-chlorprothixene is a chlorprothixene in which the double bond adopts a (Z)-configuration. It is an enantiomer of an (E)-chlorprothixene. — ChEBI

IUPAC name
(3Z)-3-(2-chlorothioxanthen-9-ylidene)-N,N-dimethylpropan-1-amine
Molecular formula
C18H18ClNS
Molecular weight
315.9 g/mol
Exact mass
315.0848484 Da
XLogP3
5.2
Topological polar surface area
28.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

TaractanChlorprothixenTruxalTraquilanClorprotixenoIaractanRentovetVetacalm
16 more reported names
TrictalTruxilPaxylChlorprotixenChlothixenChlorprothixenumChlorprotixeneTruxalettenTarasanN-714Ro 4-0403Ro-4-0403MK 184N 714Ccis-ChlorprothixeneN 714
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match667467

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H336 (14.3%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P270, P271, P301+P316, P304+P340, P319, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 7 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Source: Toxin and Toxin Target Database (T3DB)
  • Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use (kg) in Switzerland (2009): >75; Use (kg; approx.) in Germany (2009): >1000; Consumption (g per capita) in Switzerland (2009): 0.0096; Consumption (g per capita; approx.) in Germany (2009): 0.012; Excretion rate: 0.8; Calculated removal (%): 92 Source: NORMAN Suspect List Exchange
  • Uses: For treatment of psychotic disorders (e.g. schizophrenia) and of acute mania occuring as part of bipolar disorders. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Chlorprothixene (INN) and its salts

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
113-59-7
EC
204-032-8
Annex
II
Entry number
84

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 78
Nearby record in the same annex

Chlorine

CAS: 7782-50-5
EC: 231-959-5

What Annex II means for Chlorprothixene (INN) and its salts

Chlorprothixene (INN) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Chlorprothixene (INN) and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 113-59-7 is the unique numerical identifier assigned to Chlorprothixene (INN) and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Chlorprothixene (INN) and its salts

This page summarizes one Annex II record for Chlorprothixene (INN) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Chlorprothixene (INN) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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