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Annex II Entry 86 17/10/2010

N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 86

Chemical identity and properties

PubChem 2D chemical structure for CAS 126-85-2
CAS 126-85-2PubChem CID 9335

Mechlorethamine Oxide

Nitrogen mustard N-oxide is a nitrogen mustard. — ChEBI

IUPAC name
2-chloro-N-(2-chloroethyl)-N-methylethanamine oxide
Molecular formula
C5H11Cl2NO
Molecular weight
172.05 g/mol
Exact mass
171.0217694 Da
XLogP3
0.9
Topological polar surface area
18.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Nitrogen mustard N-oxide2,2'-Dichloro-N-methyldiethylamine-N-oxide2Q86QAR1PNMethylbis(beta-chloroethyl)amine N-oxideEthanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxideNSC-141949RefChem:166098Nitrogen mustard (HN-2), N-oxide
16 more reported names
Oxy-NH2HN2 amine oxideHN2 oxide mustardN-Oxyd-lost [German]N-Oxyd-mustard [German]N-Oxyd-mustardNitrogen mustard amine oxideMethyl-dichlorethylamine oxideCCRIS 449UNII-2Q86QAR1PNMethyl-bis(beta-chloroethyl)amine oxideBRN 1754386N-Methyl-di-2-chloroethylamine-N-oxideDiethylamine, 2,2'-dichloro-N-methyl-, oxideDiethylamine, 2,2'-dichloro-N-methyl-, N-oxidebis(2-chloroethyl)methylamine oxide
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match9335

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H340: May cause genetic defects [Danger Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

Chemical / IUPAC name

Nitrogen mustard N-oxide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
126-85-2
EC
—
Annex
II
Entry number
86

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 126-85-2 is the unique numerical identifier assigned to N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts

This page summarizes one Annex II record for N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for N,N-bis(2-Chloroethyl)methylamine N-oxide and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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