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Annex II Entry 740 CMR24/11/2016

Flusilazole

Flusilazole is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 740
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 85509-19-9
CAS 85509-19-9PubChem CID 73675

Flusilazole

Flusilazole is an organosilicon compound that is dimethylsilane in which the hydrogens attached to the silicon are replaced by p-fluorophenyl groups and a hydrogen attached to one of the methyl groups is replaced by a 1H-1,2,4-triazol-1-yl group. It is a broad-sepctrum fungicide used to protect a variety of crops. It has a role as a xenobiotic, an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor, an environmental contaminant and an antifungal agrochemical. It is an organosilicon compound, a member of triazoles, a member of monofluorobenzenes, a conazole fungicide and a triazole fungicide. — ChEBI

IUPAC name
bis(4-fluorophenyl)-methyl-(1,2,4-triazol-1-ylmethyl)silane
Molecular formula
C16H15F2N3Si
Molecular weight
315.39 g/mol
Exact mass
315.10033035 Da
Topological polar surface area
30.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

NustarFlusilazolOlympPunchFluzilazolSanctionDPX-H 6573F3WG2VVD87
16 more reported names
Bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-ylmethyl)silaneDPX-H65731-((Bis(4-fluorophenyl)(methyl)silyl)methyl)-1H-1,2,4-triazoleCHEBI:819221-{[bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole1H-1,2,4-Triazole, 1-((bis(4-fluorophenyl)methylsilyl)methyl)-bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane1H-1,2,4-Triazole, 1-[[bis(4-fluorophenyl)methylsilyl]methyl]-1-([Bis(4-fluorophenyl)(methyl)silyl]methyl)-1H-1,2,4-triazoleRefChem:141052617-717-5Flusilazole [ISO]1-((Bis(4-fluorophenyl)methylsilyl)methyl)-1H-1,2,4-triazole1-[[Bis(4-fluorophenyl)methylsilyl]methyl]-1H-1,2,4-triazolePunch 40ECCaswell No. 419K
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Flusilazole

Chemical / IUPAC name

bis(4-fluorophenyl)(methyl)(1H-1,2,4-triazol-1-ylmethyl)silane

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓
Cat. 2✓——

Key data

CAS
85509-19-9
EC
617-717-5
Annex
II
Entry number
740

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

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EC: 200-541-4
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Formamide

CAS: 75-12-7
EC: 200-842-0
Annex II 736
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Flumioxazin

CAS: 103361-09-7
EC: 600-425-7
Annex II 735
Nearby record in the same annex

Carbadox

CAS: 6804-07-5
EC: 229-879-0
Annex II 734
Nearby record in the same annex

Captafol

CAS: 2425-06-1
EC: 219-363-3

What Annex II means for Flusilazole

Flusilazole is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Flusilazole is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 85509-19-9 is the unique numerical identifier assigned to Flusilazole by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Flusilazole has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Flusilazole

This page summarizes one Annex II record for Flusilazole from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Flusilazole, but confirm any final regulatory decision against the current official annex wording and source files.

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