Captafol
Captafol is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Captafol
Captafol is a dicarboximide that captan in which the trichloromethyl group is replaced by a 1,1,2,2-tetrachloroethyl group. A broad-spectrum fungicide used to control diseases in fruit and potatoes, it is no longer approved for use in the European Community. It has a role as an antifungal agrochemical. It is a member of isoindoles, an organosulfur compound, an organochlorine compound and a phthalimide fungicide. — ChEBI
- IUPAC name
- 2-(1,1,2,2-tetrachloroethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione
- Molecular formula
- C10H9Cl4NO2S
- Molecular weight
- 349.1 g/mol
- Exact mass
- 348.907860 Da
- XLogP3
- 3.8
- Topological polar surface area
- 62.7 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:81938
- ChEMBL:CHEMBL1893263
- EPA DTXSID:DTXSID4020242
- PubMed:33352482
- PubMed:30561685
- PubMed:29228274
- PubMed:12726998
- PubMed:12113771
- PubMed:9022123
- PubMed:8678907
- PubMed:8441825
- PubMed:2962818
- PubMed:2949929
- PubMed:1765226
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Captafol
Chemical / IUPAC name
1,2,3,6-tetrahydro-N-(1,1,2,2-tetrachloroethylthio)phthalimide
Regulatory information
SCCS opinions
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | ✓ | — | — |
Key data
Related records for Captafol
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Imidazolidine-2-thione (Ethylene thiourea)
2-Methylaziridine (propyleneimine)
(Methyl-ONN-azoxy)methyl acetate
What Annex II means for Captafol
Captafol is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record Captafol
This page summarizes one Annex II record for Captafol from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Captafol, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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