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Annex II Entry 398 20/10/2010

Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10)

Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 398

Chemical identity and properties

PubChem 2D chemical structure for CAS 509-34-2
CAS 509-34-2PubChem CID 62357

Solvent Red 49

IUPAC name
3',6'-bis(diethylamino)spiro[2-benzofuran-3,9'-xanthene]-1-one
Molecular formula
C28H30N2O3
Molecular weight
442.5 g/mol
Exact mass
442.22564282 Da
XLogP3
5.8
Topological polar surface area
42.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

Rhodamine B baseC.I. Solvent Red 49Rhodamine B lactoneLacquer Pink SRhodamine S lactoneEljon Magenta TonerWaxoline Rhodamine BWaxoline Rhodamine BS
16 more reported names
Aizen Rhodamine B BaseRhodamine B Base ExtraRhodamine B Extra BaseRhodamine Base B ExtraKMK3588HIDRHODAMINE BASE BNSC-43944AIZEN SOT PINK 1Fluoran, 3',6'-bis(diethylamino)-UNII-KMK3588HIDBASO RED 546J34.966FC.I.45170:1EINECS 208-096-8NSC 439443',6'-Bis(diethylamino)spiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 81-88-9
CAS 81-88-9PubChem CID 6694

Rhodamine B

Rhodamine B is an organic chloride salt having N-[9-(2-carboxyphenyl)-6-(diethylamino)-3H-xanthen-3-ylidene]-N-ethylethanaminium as the counterion. An amphoteric dye commonly used as a fluorochrome. It has a role as a fluorescent probe, a fluorochrome and a histological dye. It is an organic chloride salt and a xanthene dye. It contains a rhodamine B(1+). — ChEBI

IUPAC name
[9-(2-carboxyphenyl)-6-(diethylamino)xanthen-3-ylidene]-diethylazanium chloride
Molecular formula
C28H31ClN2O3
Molecular weight
479.0 g/mol
Exact mass
478.2023205 Da
Topological polar surface area
52.8 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
2
Defined stereocentres
0

Also known as

Basic Violet 10Brilliant Pink BTetraethylrhodamineRhodamine B chlorideCalcozine Red BXSymulex Magenta FRhodamineRhodamine O
16 more reported names
Rheonine BRhodamine FBGeranium lake NRhodamine BARhodamine BFRhodamine BLRhodamine BNRhodamine BSRhodamine BXRhodamine BXLRhodamine BXPBasic Rose RedRhodamine Lake Red BSymulex Pink FADC Rhodamine BEdicol Suppa Rose BS
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
81-88-9 / 509-34-2
EC
201-383-9 / 208-096-8
Annex
II
Entry number
398

Inventory links for Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10)

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 399
Nearby record in the same annex

Lidocaine (INN)

CAS: 137-58-6
EC: 205-302-8
Annex II 400
Nearby record in the same annex

1,2-Epoxybutane

CAS: 106-88-7
EC: 203-438-2
Annex II 393
Nearby record in the same annex

Acetonitrile

CAS: 75-05-8
EC: 200-835-2

What Annex II means for Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10)

Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 81-88-9 / 509-34-2 is the unique numerical identifier assigned to Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10)

This page summarizes one Annex II record for Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Colouring agent CI 45170, Colouring agent CI 45170:1 (Basic Violet 10), but confirm any final regulatory decision against the current official annex wording and source files.

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