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Annex II Entry 380 CMR24/11/2016

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 380
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 467-63-0
CAS 467-63-0PubChem CID 68050

C.I. 42555:1

Methylrosaniline is a benzenoid aromatic compound. — ChEBI

IUPAC name
tris[4-(dimethylamino)phenyl]methanol
Molecular formula
C25H31N3O
Molecular weight
389.5 g/mol
Exact mass
389.246712621 Da
XLogP3
4.6
Topological polar surface area
30.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

MethylrosanilineCrystal Violet CarbinolMethylrosanilinumCrystal Violet Carbinol BaseViolet 5BO BaseViolet 5BNO BaseC.I. Solvent Violet 9Aizen Crystal Violet Base
16 more reported names
Waxoline Violet 10BCarbinolbase des kristallviolettC.I. Basic Violet 3, carbinol4,4',4''-DimethylaminotriphenylcarbinolTri(p-dimethylaminophenyl)methanolEINECS 207-396-6BRN 2225285C.I. 42555BCarbinolbase des kristallviolett [German]p,p',p''-Tris(dimethylamino)trityl alcoholMethanol, tris(p-(dimethylamino)phenyl)-4-13-00-02284 (Beilstein Handbook Reference)Benzenemethanol, 4-(dimethylamino)-alpha,alpha-bis(4-(dimethylamino)phenyl)-4-(Dimethylamino)-alpha,alpha-bis(4-(dimethylamino)phenyl)-benzenemethanolBenzenemethanol, 4-(dimethylamino)-.alpha.,.alpha.-bis[4-(dimethylamino)phenyl]-Benzenemethanol, 4-(dimethylamino)-alpha,alpha-bis[4-(dimethylamino)phenyl]-
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 548-62-9
CAS 548-62-9PubChem CID 11057

Crystal Violet

Crystal violet is an organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain. It has a role as an antibacterial agent, an anthelminthic drug, an antifungal agent, an antiseptic drug and a histological dye. It contains a crystal violet cation. — ChEBI

IUPAC name
[4-[bis[4-(dimethylamino)phenyl]methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium chloride
Molecular formula
C25H30ClN3
Molecular weight
408.0 g/mol
Exact mass
407.2128257 Da
Topological polar surface area
9.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
2
Defined stereocentres
0

Also known as

gentian violetmethylrosanilinium chlorideAniline VioletHexamethyl VioletMethyl Violet 10BGentiavermMethylrosaniline chloridePyoktanin
16 more reported names
AdergonAtmonilAverminAxurisVianinViocidBadilBismuth VioletHexamethylpararosaniline chlorideBasic Violet BNGentersalGenticidGentiolettenOxycolorVermicidGenapax
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

Chemical / IUPAC name

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
548-62-9[1] / 467-63-0[2]
EC
208-953-6[1] / 207-396-6[2]
Annex
II
Entry number
380

Inventory links for 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

Inventory Restriction reference
Ref 54826

BASIC VIOLET 3

CAS: 548-62-9
EC: 208-953-6

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 548-62-9[1] / 467-63-0[2] is the unique numerical identifier assigned to 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2]

This page summarizes one Annex II record for 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-[[4,4'-bis(dimethylamino)benzhydrylidene]cyclohexa-2,5-dien-1-ylidene]dimethylammonium chloride [1]; tris[4-(dimethylamino) phenyl]methanol [2], but confirm any final regulatory decision against the current official annex wording and source files.

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