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Annex II Entry 374 20/10/2010

Phytolacca spp. and their preparations

Phytolacca spp. and their preparations is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 374

Chemical identity and properties

PubChem 2D chemical structure for CAS 65497-07-6
CAS 65497-07-6PubChem CID 11657924

Esculentoside A

Olean-12-ene-28,29-dioic acid,3-[(4-O-b-D-glucopyranosyl-b-D-xylopyranosyl)oxy]-2,23-dihydroxy-,29-methyl ester, (2b,3b,4a,20b)- has been reported in Phytolacca acinosa with data available. — LOTUS - the natural products occurrence database

IUPAC name
(2S,4aR,6aR,6aS,6bR,8aR,9R,10R,11S,12aR,14bS)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-11-hydroxy-9-(hydroxymethyl)-2-methoxycarbonyl-2,6a,6b,9,12a-pentamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Molecular formula
C42H66O16
Molecular weight
827.0 g/mol
Exact mass
826.43508601 Da
XLogP3
0.8
Topological polar surface area
262.0 Ų
Hydrogen-bond donors
9
Hydrogen-bond acceptors
16
Covalent units
1
Defined stereocentres
20

Also known as

Olean-12-ene-28,29-dioic acid, 3-((4-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxy-, 29-methyl ester, (2beta,3beta,4alpha,20beta)-Olean-12-ene-28,29-dioic acid, 3-[(4-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2beta,3beta,4alpha,20beta)-RefChem:137846683-197-1Olean-12-ene-28,29-dioic acid,3-[(4-O-b-D-glucopyranosyl-b-D-xylopyranosyl)oxy]-2,23-dihydroxy-,29-methyl ester, (2b,3b,4a,20b)-JT3XUF9LU9Esculentoside A (Standard)Esculentoside A USP/EP/BP
11 more reported names
EX-A8013PHY-N0632RPhytolaccoside E (Esculentoside A)HY-N0632CCG-270513EBC-520241AS-76755CS-0009623Esculentoside A, 98%, from Phytolacca acinosa Roxb.(2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester3beta-[(4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy]-2beta,23-dihydroxy-30-methoxy-30-oxoolean-12-en-28-oic acid
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Phytolacca spp. and their preparations

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
65497-07-6 / 60820-94-2
EC
—
Annex
II
Entry number
374

Inventory links for Phytolacca spp. and their preparations

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Phytolacca spp. and their preparations

Phytolacca spp. and their preparations is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 2 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Phytolacca spp. and their preparations is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 65497-07-6 / 60820-94-2 is the unique numerical identifier assigned to Phytolacca spp. and their preparations by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Phytolacca spp. and their preparations

This page summarizes one Annex II record for Phytolacca spp. and their preparations from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Phytolacca spp. and their preparations, but confirm any final regulatory decision against the current official annex wording and source files.

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