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Annex II Entry 381 15/10/2010

Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))

Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 381

Chemical identity and properties

PubChem 2D chemical structure for CAS 14779-78-3
CAS 14779-78-3PubChem CID 26890

Benzoic acid, 4-(dimethylamino)-, pentyl ester

Padimate A is an ester derivative of PABA and an ingredient in some sunscreens. It absorbs ultraviolet rays thereby preventing sunburn, however, its chemical structure and behaviour is similar to an industrial free radical generator. In Europe this chemical was withdrawn in 1989 for unstated reasons and in the US it was never approved for use in sunscreens. — DrugBank

IUPAC name
pentyl 4-(dimethylamino)benzoate
Molecular formula
C14H21NO2
Molecular weight
235.32 g/mol
Exact mass
235.157228913 Da
XLogP3
4.3
Topological polar surface area
29.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Padimate AAmyl-p-dimethylaminobenzoateAmyl dimethyl-PABAAmyl 4-(dimethylamino)benzoatePentyl dimethyl PABAAmyl P-(Dimethylamino)benzoate3I0HW37A8QAmyl dimethylaminobenzoate
16 more reported names
amyl p-n,n-dimethylaminobenzoateAMYL N,N-DIMETHYL-4-AMINOBENZOATEAMYL N,N-DIMETHYL-P-AMINOBENZOATERefChem:85828077FU10423XPadimate A [USAN]pentyl p-dimethylaminobenzoateAmyl dimethyl pabaPadimate A (USAN)Pentyl p-(dimethylamino)benzoateEINECS 238-849-6UNII-3I0HW37A8QAmylp-(dimethylamino)benzoatep-Dimethylaminobenzoic acid, pentyl esterp-dimethylinamyl-benzoateBENZOIC ACID, p-DIMETHYLAMINO-, PENTYL ESTER
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
14779-78-3
EC
238-849-6
Annex
II
Entry number
381

Inventory links for Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))

Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 14779-78-3 is the unique numerical identifier assigned to Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN))

This page summarizes one Annex II record for Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Amyl 4-dimethylaminobenzoate, mixed isomers (Padimate A (INN)), but confirm any final regulatory decision against the current official annex wording and source files.

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