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Annex II Entry 370 CMR24/11/2016

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 370
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 133-06-2
CAS 133-06-2PubChem CID 8606

Captan

Captan is a dicarboximide that is 3a,4,7,7a-tetrahydrophthalimide in which the hydrogen attached to the nitrogen is replaced by a trichloromethyl group. A non-systemic fungicide introduced in the 1950s, it is widely used for the control of fungal diseases in fruits, vegetables, and ornamental crops. It has a role as an antifungal agrochemical. It is a member of isoindoles, an organosulfur compound, an organochlorine compound and a phthalimide fungicide. — ChEBI

IUPAC name
2-(trichloromethylsulfanyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione
Molecular formula
C9H8Cl3NO2S
Molecular weight
300.6 g/mol
Exact mass
298.934133 Da
XLogP3
2.4
Topological polar surface area
62.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

AacaptanOrthocideMerpanVondcaptanAmercideCaptaneMalipurNeracid
16 more reported names
CaptafCaptexKaptanOrthocide 406TrimegolVancide 89VanicideBangtonCaptabHexacapOsocideUgecapStauffer captanLe captaneVangard KOrthocide 50
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

Chemical / IUPAC name

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Other directives

(EC) 2009/790

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
133-06-2
EC
205-087-0
Annex
II
Entry number
370

Inventory links for captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

Inventory Restriction reference
Ref 84500

CAPTAN

CAS: 133-06-2
EC: 205-087-0

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 366
Nearby record in the same annex

Chloroform

CAS: 67-66-3
EC: 200-663-8

What Annex II means for captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 133-06-2 is the unique numerical identifier assigned to captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide

This page summarizes one Annex II record for captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for captan (ISO); 1,2,3,6-tetrahydro-N-(trichloromethylthio)phthalimide, but confirm any final regulatory decision against the current official annex wording and source files.

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