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Annex II Entry 360 CMR24/11/2016

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 360
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 94-59-7
CAS 94-59-7PubChem CID 5144

Safrole

Safrole appears as clear colorless or slightly yellow liquid with the odor of sassafras. Denser than water (density 1.09 g / cm3) and insoluble in water. Hence sinks in water. Obtained from oil of sassafras or oil of camphor. — CAMEO Chemicals

IUPAC name
5-prop-2-enyl-1,3-benzodioxole
Molecular formula
C10H10O2
Molecular weight
162.18 g/mol
Exact mass
162.068079557 Da
XLogP3
3.0
Topological polar surface area
18.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

SafrolShikimoleShikomol5-Allyl-1,3-benzodioxoleSafrole MFSafrene1,3-Benzodioxole, 5-(2-propenyl)-Allylcatechol methylene ether
16 more reported names
Shikimol5-(2-Propenyl)-1,3-benzodioxolem-Allylpyrocatechin methylene ether4-Allyl-1,2-methylenedioxybenzene4-Allylpyrocatechol formaldehyde acetalAllylpyrocatechol methylene ether3,4-(Methylenedioxy)allylbenzene1-Allyl-3,4-methylenedioxybenzeneBenzene, 4-allyl-1,2-(methylenedioxy)-Allyldioxybenzene methylene ether1,2-Methylenedioxy-4-allylbenzene1,3-Benzodioxole, 5-allyl-5-(prop-2-en-1-yl)-2H-1,3-benzodioxoleNSC-118313,4-methylenedioxy-allylbenzene3-(3,4-Methylenedioxyphenyl)prop-1-ene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children

Chemical / IUPAC name

5-allyl-1,3-benzodioxole

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓——
Cat. 2—✓—

Key data

CAS
94-59-7
EC
202-345-4
Annex
II
Entry number
360

Inventory links for Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 366
Nearby record in the same annex

Chloroform

CAS: 67-66-3
EC: 200-663-8

What Annex II means for Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 8 CosIng inventory ingredients for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 94-59-7 is the unique numerical identifier assigned to Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children

This page summarizes one Annex II record for Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children, but confirm any final regulatory decision against the current official annex wording and source files.

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