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Annex II Entry 329 15/10/2010

Gallamine triethiodide (INN)

Gallamine triethiodide (INN) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 329

Chemical identity and properties

PubChem 2D chemical structure for CAS 65-29-2
CAS 65-29-2PubChem CID 6172

Gallamine Triethiodide

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198) — DrugBank

IUPAC name
2-[2,3-bis[2-(triethylazaniumyl)ethoxy]phenoxy]ethyl-triethylazanium triiodide
Molecular formula
C30H60I3N3O3
Molecular weight
891.5 g/mol
Exact mass
891.1769 Da
Topological polar surface area
27.7 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Covalent units
4
Defined stereocentres
0

Also known as

FlaxedilBenzcurine iodideRemyolanSyncurarineRelaxanSincurarineRetensinTricuran
16 more reported names
Gallamin triethiodideGallaminii iodidumGallamine-3ETIGallamine triiodoethylateFourneau 2559Gallamine iodideGallamina triodoetilatoGallamini triethiodidumTriethiodure de gallamineGallamone triethiodideRP 3697Triiodoethylate de gallamine1,2,3-Tri(beta-diethylaminoethoxy)benzene triethiodideF 25591,2,3-Tris(2-diethylaminoethoxy)benzene triethiodideTrietioduro de galamina
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Gallamine triethiodide (INN)

Chemical / IUPAC name

Ethanaminium, 2,2',2''-(1,2,3-benzenetriyltris(oxy))tris(N,N,N-triethyl)-, triiodide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
65-29-2
EC
200-605-1
Annex
II
Entry number
329

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 328
Nearby record in the same annex

Tretamine (INN)

CAS: 51-18-3
EC: 200-083-5

What Annex II means for Gallamine triethiodide (INN)

Gallamine triethiodide (INN) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Gallamine triethiodide (INN) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 65-29-2 is the unique numerical identifier assigned to Gallamine triethiodide (INN) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Gallamine triethiodide (INN)

This page summarizes one Annex II record for Gallamine triethiodide (INN) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Gallamine triethiodide (INN), but confirm any final regulatory decision against the current official annex wording and source files.

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