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Annex II Entry 327 15/10/2010

Trichlormethine (INN) and its salts

Trichlormethine (INN) and its salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 327

Chemical identity and properties

PubChem 2D chemical structure for CAS 555-77-1
CAS 555-77-1PubChem CID 5561

Tris(2-chloroethyl)amine

Trichlormethine (Trimustine Hydrochloride) can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC). — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name
2-chloro-N,N-bis(2-chloroethyl)ethanamine
Molecular formula
C6H12Cl3N
Molecular weight
204.5 g/mol
Exact mass
203.003532 Da
XLogP3
2.0
Topological polar surface area
3.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

trichlormethineTrimustineSinalost baseTrimitan baseTriclormetina2,2',2''-TrichlorotriethylamineAgent HN3trichlorotriethylamine
16 more reported names
Tris(beta-chloroethyl)amineTrichlormethinumTL 145TS 160Tri-(2-chloroethyl)amineTriethylamine, 2,2',2''-trichloro-A 872966WBM7N0NMEthanamine, 2-chloro-N,N-bis(2-chloroethyl)-NSC-260424AI3-16198trichloromethine2,2',2''-trichloroethylamineTriethylamine, 2,2',2"-trichloro-RefChem:9335162,2',2"-trichlorotriethylamine
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6138-32-5
CAS 6138-32-5PubChem CID 111157

Triethylamine, 2,2',2''-trichloro-, picrate

IUPAC name
2-chloro-N,N-bis(2-chloroethyl)ethanamine;2,4,6-trinitrophenol
Molecular formula
C12H15Cl3N4O7
Molecular weight
433.6 g/mol
Exact mass
432.000632 Da
Topological polar surface area
161.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
8
Covalent units
2
Defined stereocentres
0

Also known as

Tri-(beta-chloroethyl)ammonium picrateAmmonium, tri-(beta-chloroethyl)-, picrateRefChem:3861632,4,6-Trinitrophenol--2-chloro-N,N-bis(2-chloroethyl)ethan-1-amine (1/1)
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 817-09-4
CAS 817-09-4PubChem CID 61220

Tris(2-chloroethyl)amine hydrochloride

Trichlormethine is an organic molecular entity. — ChEBI

IUPAC name
2-chloro-N,N-bis(2-chloroethyl)ethanamine;hydrochloride
Molecular formula
C6H13Cl4N
Molecular weight
241.0 g/mol
Exact mass
240.977260 Da
Topological polar surface area
3.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
2
Defined stereocentres
0

Also known as

Trichlormethine hydrochlorideTrimustine hydrochlorideNSC-30211NSC-759837RefChem:1100524212-442-3HN3 hydrochlorideTrichlormethin
16 more reported names
SinalostTrillekaminTrimitanLekamintris-(2-chloroethyl)-amine hydrochlorideTrichlormethine HCLHn3 hclTrichlormethinium chlorideTris-N-lostTrichlormethine (hydrochloride)2-chloro-N,N-bis(2-chloroethyl)ethanamine hydrochlorideTrichlorotriethylamine hydrochlorideTris(2-chloroethyl)ammonium chlorideSK-1002,2',2''-Trichlorotriethylamine hydrochlorideEthanamine, 2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Trichlormethine (INN) and its salts

Chemical / IUPAC name

2,2',2''-Trichlorotriethylamine

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
555-77-1 / 817-09-4 / 6138-32-5
EC
- / 212-442-3 / -
Annex
II
Entry number
327

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 328
Nearby record in the same annex

Tretamine (INN)

CAS: 51-18-3
EC: 200-083-5

What Annex II means for Trichlormethine (INN) and its salts

Trichlormethine (INN) and its salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Trichlormethine (INN) and its salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 555-77-1 / 817-09-4 / 6138-32-5 is the unique numerical identifier assigned to Trichlormethine (INN) and its salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Trichlormethine (INN) and its salts

This page summarizes one Annex II record for Trichlormethine (INN) and its salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Trichlormethine (INN) and its salts, but confirm any final regulatory decision against the current official annex wording and source files.

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