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Annex II Entry 317 15/10/2010

Thallium and its compounds

Thallium and its compounds is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 317

Chemical identity and properties

PubChem 2D chemical structure for CAS 7440-28-0
CAS 7440-28-0PubChem CID 5359464

Thallium

Pure thallium is a bluish-white metal that is found in trace amounts in the earth's crust. In the past, thallium was obtained as a by-product from smelting other metals; however, it has not been produced in the United States since 1984. Currently, all the thallium is obtained from imports and from thallium reserves.. In its pure form, thallium is odorless and tasteless. It can also be found combined with other substances such as bromine, chlorine, fluorine, and iodine. When it's combined, it appears colorless-to-white or yellow.. Thallium is used mostly in manufacturing electronic devices, switches, and closures, primarily for the semiconductor industry. It also has limited use in the manufacture of special glass and for certain medical procedures. — Agency for Toxic Substances and Disease Registry (ATSDR)

IUPAC name
thallium
Molecular formula
Tl
Molecular weight
204.383 g/mol
Exact mass
204.97443 Da
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

RamorThallium, elementalThulium Metallicumlambda1-thallanyliumThallium 205MUSCLE SPASMSRefChem:56120THALLIUM METALLICUM
16 more reported names
AD84R52XLFCHEBI:30440CHEBI:37109231-138-181TlTalioTlThallium granulesRamor; Thallium, metallic; Thallium, elemental;Thallium Standard: Tl @ 1000 microg/mL in 5% HNO3Thallium Standard: Tl @ 10000 microg/mL in 5% HNO3Thallium AA Standard: Tl @ 1000 microg/mL in 5% HNO3Thallium Standard: Tl @ 1000 microg/g in Hydrocarbon Oilthallium atomAtomic ThalliumElement Thallium
Open full PubChem recordPubChem annotations3D structure image

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Thallium and its compounds

Regulatory information

Regulation

(EC) 2009/1223

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Key data

CAS
7440-28-0
EC
231-138-1
Annex
II
Entry number
317

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Thallium and its compounds

Thallium and its compounds is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Thallium and its compounds is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 7440-28-0 is the unique numerical identifier assigned to Thallium and its compounds by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Thallium and its compounds

This page summarizes one Annex II record for Thallium and its compounds from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Thallium and its compounds, but confirm any final regulatory decision against the current official annex wording and source files.

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