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Annex II Entry 1695 24/08/2023

Ammonium bromide

Ammonium bromide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1695

Chemical identity and properties

PubChem 2D chemical structure for CAS 12124-97-9
CAS 12124-97-9PubChem CID 25514

Ammonium Bromide

Ammonium bromide is an ammonium salt composed of ammonium and bromide ions in a 1:1 ratio. It is a bromide salt and an ammonium salt. — ChEBI

IUPAC name
azanium bromide
Molecular formula
BrH4N
Molecular weight
97.94 g/mol
Exact mass
96.95271 Da
Topological polar surface area
1.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
2
Defined stereocentres
0

Also known as

NervineAmmonium bromatumAmmonii bromidumHydrobromic acid monoammoniateR0JB3224WSCHEBI:85364Ammoniun BromatumRefChem:58076
16 more reported names
235-183-8Ammonium bromide ((NH4)Br)azanium;bromideNH4BrFlamex PA; Flovan BU; Fuzzicide; Hydrobromic acid monoammoniate; Spectrum XD 3899EINECS 235-183-8UNII-R0JB3224WSAmmonium Bromide; Flamex PA; Flovan BU; Fuzzicide; Hydrobromic Acid MonoammoniateAMMONIUMBROMIDEH4BrN(NH4)BrEC 235-183-8AMMONIUM BROMIDE [MI]Ammonium bromide, Puratronic?AMMONIUM BROMIDE [HSDB]AMMONIUM BROMATUM [HPUS]
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External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match25514

Attributed physical-property, hazard, environmental and use annotations.

  • Autoignition Temperature: Not flammable (USCG, 1999) Source: CAMEO Chemicals
  • First Aid: EYES AND SKIN: Flush with large amounts of water.; INGESTION: Induce vomiting and call a doctor. (USCG, 1999) Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P263, P264, P264+P265, P270, P271, P280, P304+P340, P305+P351+P338, P318, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.4% (3 of 704) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (99.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336 (21%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360FD (17.8%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H362 (20.9%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]; H372 (20.9%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P263, P264, P264+P265, P270, P271, P280, P304+P340, P305+P351+P338, P318, P319, P337+P317, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 704 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 704 reports by companies.; There are 11 notifications provided by 701 of 704 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P304+P340, P305+P351+P338, P308+P316, P318, P319, P337+P317, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Ammonium bromide exists as white crystals or granules. It is used in process engraving and lithography, fireproofing of wood, and as a corrosion inhibitor. Bromide- containing medications is a prominent former use. HUMAN EXPOSURE AND TOXICITY: The warning symptoms of bromide intoxication, bromism, include mental dullness, slurred speech, weakened memory, apathy, anorexia, constipation, drowsiness and loss of sensitivity to touch and pain. These symptoms disappear on discontinuing the drug, but continued use leads to more serious symptoms including restlessness, disorientation, ocular disturbances, ataxia, hallucinations, delirium, stupor and coma. Bromide rash, of an acneform, nodular, or sometimes erythematous type, is of fairly common occurrence but may be absent even in patients who have developed severe mental symptoms. Transplacental bromism had been described in the literature. ANIMAL STUDIES: Ammonium bromide was not irritating to skin, but slightly irritating to eyes in rabbits. Ames test conducted in Salmonella typhimurium strains TA1535,TA100,TA1538,TA98,TA1537 with and without metabolic activation was negative. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Ammonium bromide

Regulatory information

Regulation

(EU) 2023/1490

See every entry this act set

Key data

CAS
12124-97-9
EC
235-183-8
Annex
II
Entry number
1695

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Ammonium bromide

Ammonium bromide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Ammonium bromide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 12124-97-9 is the unique numerical identifier assigned to Ammonium bromide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Ammonium bromide

This page summarizes one Annex II record for Ammonium bromide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Ammonium bromide, but confirm any final regulatory decision against the current official annex wording and source files.

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