What is CAS 120-32-1 for Clorofene; chlorophene; 2-benzyl-4-chlorophenol?

CAS 120-32-1 is the unique numerical identifier assigned to Clorofene; chlorophene; 2-benzyl-4-chlorophenol by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 1602 CMR30/07/2020

Clorofene; chlorophene; 2-benzyl-4-chlorophenol

Q: How do I check if my product formula contains Clorofene; chlorophene; 2-benzyl-4-chlorophenol?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Clorofene; chlorophene; 2-benzyl-4-chlorophenol is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1602

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 120-32-1

CAS 120-32-1PubChem CID 8425

Chlorophene

2-benzyl-4-chlorophenol is a diarylmethane. — ChEBI

IUPAC name: 2-benzyl-4-chlorophenol

Molecular formula: C13H11ClO
Molecular weight: 218.68 g/mol
Exact mass: 218.0498427 Da
XLogP3: 4.0
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

CloropheneSantophen 14-Chloro-2-benzylphenolPhenol, 4-chloro-2-(phenylmethyl)-NeosabenylSeptiphene5-Chloro-2-hydroxydiphenylmethaneBenzylchlorophenol

16 more reported names

Santophen I germicideSantophen ISantophen 1 flakeClorofenoKetolin-HOrthobenzylparachlorophenolOrthobenzyl-p-chlorophenolClorofenumNSC-599894-Chloro-alpha-phenyl-o-cresol7560BB0BO3chlorofeneRefChem:577754204-385-8ClorofeneO-BENZYL-P-CHLOROPHENOL

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:228003
ChEMBL:CHEMBL1328919
EPA DTXSID:DTXSID5020154
PubMed:33049310
PubMed:29228274
PubMed:28728110
PubMed:22649928
PubMed:21251949
PubMed:20629411
PubMed:18822043
PubMed:16678383
PubMed:15546637
PubMed:12537123
PubMed:11417646
PubMed:8529821

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8425

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 320 to 324 °F at 3.5 mmHg (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: 160-162 °C at 3.5 mm Hg Source: Hazardous Substances Data Bank (HSDB)

Color/Form: White to light tan or pink flakes Source: Hazardous Substances Data Bank (HSDB)

Density: 1.22 (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
Density: 1.185 at 58 °C Source: Hazardous Substances Data Bank (HSDB)

Flash Point: 370 °F (NTP, 1992) Source: CAMEO Chemicals

LogP: log Kow = 3.6 Source: Hazardous Substances Data Bank (HSDB)

Melting Point: 119.3 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 48.5 °C Source: Hazardous Substances Data Bank (HSDB)

Odor: White to light tan or pink flakes Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Ortho-benzyl-para-chlorophenol appears as white to light tan or pink flakes or white crystals. Insoluble in water. Slight phenolic odor. (NTP, 1992) Source: CAMEO Chemicals
Physical Description: White to light tan or pink solid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: less than 1 mg/mL at 61 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Highly sol in alcohol and other org solvents Source: Hazardous Substances Data Bank (HSDB)
Solubility: In water, 149 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)

Vapor Pressure: 0.1 mmHg at 68 °F (NTP, 1992) Source: CAMEO Chemicals
Vapor Pressure: 0.0000506 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: 1.87X10-7 kPa = 1.4X10-6 mm Hg /extrapolated/ Source: Hazardous Substances Data Bank (HSDB)

Substance: o-Benzyl-p-Chlorophenol Source: NTP Technical Reports
NTP Technical Report: TR-444: One-Year Initiation/Promotion Study of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in Swiss (CD-1) Mice (Mouse Skin Study) (1995 ) Source: NTP Technical Reports
Peer Review Date: 11/17/93 Source: NTP Technical Reports
Note: Initiation/Promotion Study Source: NTP Technical Reports
Summary: Under the conditions of this 1-year mouse skin initiation/promotion study in Swiss (CD-1) mice, o -benzyl- p -chlorophenol was a cutaneous irritant and a weak skin tumor promoter relative to strong promoters such as TPA. BCP had no activity as an initiator or as a complete carcinogen. Source: NTP Technical Reports
NTP Technical Report: TR-424: Toxicology and Carcinogenesis Studies of o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1994 ) Source: NTP Technical Reports
Peer Review Date: 12/01/92 Source: NTP Technical Reports
Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
Conclusion for Male Mice: Some Evidence Source: NTP Technical Reports
Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
Summary: Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenic activity of o-benzyl-p-chlorophenol in male F344/N rats receiving 30, 60, or 120 mg/kg body weight. There was equivocal evidence of carcinogenic activity of o-benzyl-p-chlorophenol in female F344/N rats based on the occurrence of two rare renal transitional cell carcinomas. There was some evidence of carcinogenic activity of o-benzyl-p-chlorophenol in male B6C3F1 mice based on increased incidences of renal tubule adenoma and renal tubule adenoma or carcinoma (combined). There was no evidence of carcinogenic activity of o-benzyl-p-chlorophenol in female B6C3F1, mice receiving 120, 240, or 480 mg/kg.; o-Benzyl-p-chlorophenol was nephrotoxic for male and female F344/N rats and B6C3F1 mice. The severity of nephropathy was increased in male and female rats and the incidence and severity of nephropathy was increased in male and female mice. The incidence and severity of nephropathy increased with length of treatment. Other lesions considered to be associated with the nephropathy and the secondary hyperparathyroidism in male rats and in male and female mice included fibrous osteodystrophy and soft t Source: NTP Technical Reports

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361f: Suspected of damaging fertility [Warning Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P332+P317, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Note: This chemical does not meet GHS hazard criteria for 3.3% (5 of 150) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (42%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (69.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (34%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (90.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (31.3%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (37.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351 (31.3%): Suspected of causing cancer [Warning Carcinogenicity]; H361 (28.7%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H373 (31.3%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (66%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (62%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (24.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P333+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 150 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 150 reports by companies.; There are 13 notifications provided by 145 of 150 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P354+P338, P308+P316, P317, P318, P319, P321, P332+P317, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Cosmetic Ingredient Review Conclusion: The CIR Expert Panel concludes that the available data are insufficient to support safety of Dichlorophene or Chlorophene. Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Ingredients for which the data are insufficient and their use in cosmetics is not supported Source: Cosmetic Ingredient Review (CIR)
Toxicity Summary: AR binding was observed for clorophene, which were both associated with delays in sexual development and decrements in reproductive performance. Source: Toxin and Toxin Target Database (T3DB)

Environmental Bioconcentration: A BCF value of 75 was measured for bluegill sunfish(1). Bluegill sunfish (Lepomis machrochirus) were exposed to 0.057 mg/L o-benzyl-p-chlorophenol for a period of 96 hours followed by a depuration period of 96 hours to determine the ability of the fish to metabolize and eliminate o-benzyl-p-chlorophenol. Depuration rate constants were from 4.67 to 6.94/days with a half-life of 0.14 days(1). The rate constant of o-benzyl-p-chlorophenol uptake in fish ranged from 11.8 to 13.8/days with a half-life of 0.06 days. According to a classification scheme(2), this BCF value suggests that bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value of 2,050(2), indicates that o-benzyl-p-chlorophenol is expected to have slight mobility in soil(SRC). Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 2.7X10-9 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 1.4X10-6 mm Hg(2), and water solubility, 149 mg/L(2). Volatilization from dry soil surfaces is not expected to be important based on the vapor pressure of this compound(2). Biodegradation of o-benzyl-p-chlorophenol is expected to occur rapidly based on degradation half-lives of 1 to 2 days, in a sewage sludge(2). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 2,050 (2), indicates that o-benzyl-p-chlorophenol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected to be an important fate process(3) based upon an estimated Henry's Law constant of 2.7X10-9 atm-cu m/mole(SRC) derived from its extrapolated vapor pressure, 1.4X10-6 mm Hg(2), and water solubility, 149 mg/L(2). According to a classification scheme(4), a BCF of 75 measured in fish(2), suggests bioconcentration in aquatic organisms is moderate(SRC). An aqueous photolysis half-life of approximately 0.7 days(2), indicates photolysis in sunlit surface waters will be an important fate process(SRC). In addition, river die-away studies using non-acclimated river water indicates that the biodegradation half-life of o-benzyl-p-chlorophenol is approximately 1 to 3 days(2,5). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), o-benzyl-p-chlorophenol, which has an extrapolated vapor pressure of 1.4X10-6 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase o-benzyl-p-chlorophenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 22 hours (SRC), calculated from its rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase o-benzyl-p-chlorophenol may be removed from the air by wet and dry deposition(SRC). o-Benzyl-p-chlorophenol has been shown to undergo direct photolysis in aqueous solutions with a half-life of approximately 0.7 days(2), which indicates that direct photolysis in the atmosphere may be possible(SRC). Source: Hazardous Substances Data Bank (HSDB)

Cosmetic Ingredient Review Link: CIR ingredient: Chlorophene Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used in household, hospital, and veterinary disinfectants; Also used as a fungicide, herbicide, antimicrobial, and cosmetics preservative; [HSDB] Used as a disinfectant (swimming pool decks, industrial water systems, poultry houses and other farming premises, food processing, and restaurants); [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Using Disinfectants or Biocides [Category: Clean]; Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For o-benzyl-p-chlorophenol (USEPA/OPP Pesticide Code: 062201) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Active principle or enhancing agent for disinfectants Source: Hazardous Substances Data Bank (HSDB)
Uses: Germicide in disinfectant solutions & soap formulations. Source: Hazardous Substances Data Bank (HSDB)
Uses: o-Benzyl-p-chlorophenol is produced as a fungicide. Source: Hazardous Substances Data Bank (HSDB)
Uses: For more Uses (Complete) data for O-BENZYL-P-CHLOROPHENOL (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Uses: Use (kg; approx.) in Germany (2009): >250; Consumption (g per capita; approx.) in Germany (2009): 0.00305; Calculated removal (%): 47.9 Source: NORMAN Suspect List Exchange
Uses: Clorophene is used as an antiseptic agent and a disinfectant in hospitals and restaurants. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Clorofene; chlorophene; 2-benzyl-4-chlorophenol

Chemical / IUPAC name

Clorofene; chlorophene; 2-benzyl-4-chlorophenol

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

Identified ingredients

CHLOROPHENE

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 2	✓	—	✓

Key data

CAS

120-32-1

204-385-8

Annex

Entry number

1602

Inventory links for Clorofene; chlorophene; 2-benzyl-4-chlorophenol

Inventory Restriction reference

Ref 32664

CHLOROPHENE

CAS: 120-32-1

EC: 204-385-8

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1601