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Annex II Entry 1600 CMR30/07/2020

Cadmium nitrate; cadmium dinitrate

Cadmium nitrate; cadmium dinitrate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1600
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 10325-94-7
CAS 10325-94-7PubChem CID 25154

Cadmium Nitrate

Cadmium nitrate is an inorganic nitrate salt having Cd(2+) as the counterion. It has a role as a genotoxin, a carcinogenic agent and a hepatotoxic agent. It is a cadmium salt and an inorganic nitrate salt. It contains a cadmium(2+). — ChEBI

IUPAC name
cadmium(2+) dinitrate
Molecular formula
CdN2O6
Molecular weight
236.42 g/mol
Exact mass
237.879001 Da
Topological polar surface area
126.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
6
Covalent units
3
Defined stereocentres
0

Also known as

Cadmium dinitrateCadmium(II) nitrateNitric acid, cadmium saltVF9RQV8VXVAI3-51840Nitric acid, cadmium salt (2:1)Cd(NO3)2CHEBI:77732
14 more reported names
(nitrooxy)cadmio nitrateRefChem:122587233-710-6cadmium(2+);dinitratecadmium(+2) cation dinitrateHSDB 276UNII-VF9RQV8VXVEINECS 233-710-6cadmium-nitrateNitric acid cadmium salt (2:1)CADMIUM NITRATE [MI]CADMIUM NITRATE [HSDB]Cadmium nitrate solution, 0.1 NDB-264614
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:77732

cadmium nitrate

An inorganic nitrate salt having Cd(2+) as the counterion.

Formula
Cd.2NO3
Average mass
236.420 g/mol
Monoisotopic mass
237.87899 Da
Formal charge
0
  • cadmium salt — is a (CHEBI:50293)
  • inorganic nitrate salt — is a (CHEBI:51084)
  • carcinogenic agent — has role (CHEBI:50903)
  • hepatotoxic agent — has role (CHEBI:50908)
  • genotoxin — has role (CHEBI:50902)
  • cadmium(2+) — has part (CHEBI:48775)
  • carcinogenic agent — has role (CHEBI:50903)
  • hepatotoxic agent — has role (CHEBI:50908)
  • genotoxin — has role (CHEBI:50902)
  • cadmium salt — is a (CHEBI:50293)
  • inorganic nitrate salt — is a (CHEBI:51084)
Additional curated names
cadmium dinitrateCadmium(II) nitrateCd(NO3)2Nitric acid, cadmium saltNitric acid, cadmium salt (2:1)
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-06-24. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match25154

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: INHALATION: remove patient to fresh air; seek medical attention.; INGESTION: give large amounts of water and induce vomiting; give milk or egg whites; seek medical attention.; EYES: flush with copious amounts of water for 15 min.; consult a physician.; SKIN: wash with soap and water. (USCG, 1999) Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H340: May cause genetic defects [Danger Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P317, P318, P319, P321, P330, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (90%): Toxic if swallowed [Danger Acute toxicity, oral]; H302+H312+H332 (31.4%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H302 (10%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (42.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H330 (90%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H332 (10%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H340 (90%): May cause genetic defects [Danger Germ cell mutagenicity]; H350 (92.9%): May cause cancer [Danger Carcinogenicity]; H360 (88.6%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (90%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P273, P280, P284, P301+P316, P301+P317, P302+P352, P304+P340, P316, P317, P318, P319, P320, P321, P330, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 70 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H340: May cause genetic defects [Danger Germ cell mutagenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P264, P270, P280, P301+P316, P308+P316, P318, P319, P321, P330, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Chronic exposure to cadmium fumes can cause chemical pneumonitis, pulmonary edema, and lung diseases such as bronchitis and emphysema. Cadmium also accumulates in the kidneys, causing permanent damage. Loss of bone density also occurs. Nitrate and nitrite poisoning causes methemoglobinemia. Nitrites may cause pregnancy complications and developmental effects. They may also be carcinogenic. (L1137, L6) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high weight molecular proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613, L8, A18, A19, A28) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: Salvinia natans (fern) exposed to cadmium nitrate for 21 days exhibited a bioconcentration factor of 960. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Mya arenaria, (soft shell clam) exposed to cadmium nitrate for 70 days exhibited a bioconcentration factor of 160. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Crassostrea virginica, (American oyster) exposed to cadmium nitrate for 98 days exhibited a bioconcentration factor of 1,220. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Lemna valdiviana (duck weed) exposed to cadmium nitrate for 21 days exhibited a bioconcentration factor of 603. Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used in photographic emulsions, nuclear reactors to control rate of nuclear fission, and glass and ceramic colorants; [HSDB] Used in storage batteries and to make red lusters in glass and porcelain; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Battery Manufacturing [Category: Industry]; Photographic Processing [Category: Other]; Glass Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Activities with risk of exposure: Ceramics making [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: In making other cadmium salts; in photographic emulsions. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Oxidation of the sulfide or sulfite under carefully controlled oxidizing atmospheres at high temperature. An alternate method involves treatment of powdered cadmium nitrate, halide, oxide, or carbonate with dimethyl sulfate. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The use of cadmium soaps as components of PVC stabilizers is decreasing because of their toxic properties. Solid PVC stabilizers contain cadmium soaps of saturated fatty acids, whereas liquid stabilizers contain soaps of unsaturated or branched, short-chain fatty acids. The soaps act as heat and light stabilizers, and soaps of saturated fatty acids are used as lubricants in the processing of PVC. Unlike other metallic soaps used in the PVC sector, cadmium soaps do not affect transparency and are suitable for hard, transparent PVC products. However, for safety reason their use is nowadays being replaced by mixtures of calcium-zinc stearate plus other stabilizers. /Cadmium metallic soaps/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Production of red lusters in glass and porcelain and in cadmium-nickel sinter plates of storage batteries. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for CADMIUM NITRATE (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Cadmium nitrate is used mainly to prepare other cadmium salts. It is also used for coloring glass and porcelain and as a flash powder in photography. (L450) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Cadmium nitrate; cadmium dinitrate

Chemical / IUPAC name

Cadmium nitrate; cadmium dinitrate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓✓—

Key data

CAS
10325-94-7
EC
233-710-6
Annex
II
Entry number
1600

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Cadmium nitrate; cadmium dinitrate

Cadmium nitrate; cadmium dinitrate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Cadmium nitrate; cadmium dinitrate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 10325-94-7 is the unique numerical identifier assigned to Cadmium nitrate; cadmium dinitrate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Cadmium nitrate; cadmium dinitrate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Cadmium nitrate; cadmium dinitrate

This page summarizes one Annex II record for Cadmium nitrate; cadmium dinitrate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Cadmium nitrate; cadmium dinitrate, but confirm any final regulatory decision against the current official annex wording and source files.

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