Skip to main content
Annex II Entry 1579 30/07/2020

Methanediol; methylene glycol

Methanediol; methylene glycol is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1579

Chemical identity and properties

PubChem 2D chemical structure for CAS 463-57-0
CAS 463-57-0PubChem CID 79015

Methanediol

Methanediol is the simplest member of the class of methanediols that is methane in which two of the hydrogens have been substituted by hydroxy groups. It is a member of methanediols, an aldehyde hydrate and a one-carbon compound. ChEBI

IUPAC name
methanediol
Molecular formula
CH4O2
Molecular weight
48.041 g/mol
Exact mass
48.021129366 Da
XLogP3
-1.0
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

Methylene glycoldihydroxymethaneCHEBI:483976Z20YM9257RefChem:156911207-339-5formaldehyde hydrateMethandiol
8 more reported names
Methanediol-UNII-6Z20YM9257EINECS 207-339-5Paraformaldehyde, powderSCHEMBL4597UNII-T0H3L6C7I5T0H3L6C7I5Aldacide; Flo-Mor; Granuform; Paraform; TransFix
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Methanediol; methylene glycol

Chemical / IUPAC name

Methanediol; methylene glycol

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

Identified ingredients

Key data

Annex
Entry number
1579

Inventory links for Methanediol; methylene glycol

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1578
Nearby record in the same annex

Paraformaldehyde

CAS: 30525-89-4
EC: 608-494-5
Annex II 1577
Nearby record in the same annex

Formaldehyde

CAS: 50-00-0
EC: 200-001-8
Annex II 1575
Nearby record in the same annex

Styrene

CAS: 100-42-5
EC: 202-851-5

What Annex II means for Methanediol; methylene glycol

Methanediol; methylene glycol is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Methanediol; methylene glycol is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 463-57-0 is the unique numerical identifier assigned to Methanediol; methylene glycol by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Source note for Annex II record Methanediol; methylene glycol

This page summarizes one Annex II record for Methanediol; methylene glycol from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Methanediol; methylene glycol, but confirm any final regulatory decision against the current official annex wording and source files.

Tools & next steps

Check your formula

Paste a full INCI list to detect Methanediol; methylene glycol and other flagged EU annex records in one pass.

INCI Checker

Compare entries

Compare Methanediol; methylene glycol side by side with another annex record to review differences in restrictions, concentrations and annex placement.

Compare

Browse the annex

See all records in Annex II and compare regulatory conditions across substances in this annex.

Open Annex II