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Annex II Entry 1569 CMR30/07/2020

4-Vinylcyclohexene

4-Vinylcyclohexene is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1569
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 100-40-3
CAS 100-40-3PubChem CID 17497

Vinylcyclohexene

Vinylcyclohexene is a colorless liquid. Floats on water. (USCG, 1999) — CAMEO Chemicals

IUPAC name
1-ethenylcyclohexene
Molecular formula
C8H12
Molecular weight
108.18 g/mol
Exact mass
108.093900383 Da
XLogP3
2.8
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

RefChem:11009921-VINYL-3-CYCLOHEXENE4-Vinyl cyclohexene4-Vinylcyclohexene-1Cyclohexene, 4-ethenyl-1-VinylcyclohexeneCyclohexene, 1-ethenyl-1-Vinyl-1-cyclohexene
11 more reported names
2622-21-1Cyclohexene, ethenyl-Cyclohexene, 1-vinyl-1-vinyl-cyclohexene2-Vinylcyclohexene1-ethenylcyclohex-1-eneHSDB 5888EINECS 220-070-8BRN 1236528vinyl cyclohexene1-vinylcyclohex-1-ene
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:82377

4-Vinylcyclohexene

Formula
C8H12
Average mass
108.184 g/mol
Monoisotopic mass
108.09390 Da
Formal charge
0
  • cyclic olefin — is a (CHEBI:33642)
  • plastic odor agent — has role (CHEBI:747343)
  • plastic odor agent — has role (CHEBI:747343)
  • cyclic olefin — is a (CHEBI:33642)
Additional curated names
4-Vinyl-1-cyclohexene
Cross-references from this source
  • CAS: 100-40-3 — KEGG COMPOUND
  • MANUAL_X_REF: C19310 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-09-04. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match17497

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Vinylcyclohexene

Chemical / IUPAC name

4-Vinylcyclohexene

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
100-40-3
EC
202-848-9
Annex
II
Entry number
1569

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1565
Nearby record in the same annex

Vinyl acetate

CAS: 108-05-4
EC: 203-545-4
Annex II 1564
Nearby record in the same annex

Gallium arsenide

CAS: 1303-00-0
EC: 215-114-8
Annex II 1575
Nearby record in the same annex

Styrene

CAS: 100-42-5
EC: 202-851-5

What Annex II means for 4-Vinylcyclohexene

4-Vinylcyclohexene is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 4-Vinylcyclohexene is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 100-40-3 is the unique numerical identifier assigned to 4-Vinylcyclohexene by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

4-Vinylcyclohexene has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-Vinylcyclohexene

This page summarizes one Annex II record for 4-Vinylcyclohexene from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Vinylcyclohexene, but confirm any final regulatory decision against the current official annex wording and source files.

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