What is CAS 1303-00-0 for Gallium arsenide?

CAS 1303-00-0 is the unique numerical identifier assigned to Gallium arsenide by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 1564 CMR30/07/2020

Gallium arsenide

Q: Is Gallium arsenide banned in EU cosmetics?

Yes. Gallium arsenide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

Q: What does the CMR classification mean for Gallium arsenide?

Gallium arsenide has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may only be used if assessed safe by the SCCS.

Q: How do I check if my product formula contains Gallium arsenide?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Gallium arsenide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1564

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 1303-00-0

CAS 1303-00-0PubChem CID 14770

Gallium arsenide

Gallium Arsenide can cause cancer according to California Labor Code. — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name: gallanylidynearsane

Molecular formula: AsGa
Molecular weight: 144.645 g/mol
Exact mass: 143.84717 Da
Topological polar surface area: 0.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

Gallium arsenide (GaAs)Gallium monoarsenideGallium monoarsenide (GaAs)GaAs27FC46GA44Gallium ArsenatumRefChem:58150215-114-8

15 more reported names

CCRIS 4020HSDB 4376EINECS 215-114-8arsinogallaneUNII-27FC46GA44GalliummonoarsenideGallium Arsenide, piecesEC 215-114-8GALLIUM ARSENIDE [MI]Gallium arsenide, pieces, 99.999% trace metals basisGallium arsenide Optical Window, 12.7mm (0.5in) dia x 1mm (0.04in) thickGallium arsenide Optical Window, 12.7mm (0.5in) dia x 2mm (0.08in) thickGallium arsenide Optical Window, 25.4mm (1.0in) dia x 2mm (0.08in) thickGallium arsenide Optical Window, 50.8mm (2.0in) dia x 2mm (0.08in) thickGallium arsenide, (single crystal substrate), <100>, diam. x thickness 2 in. x 0.5 mm

Open full PubChem record PubChem annotations 3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match14770

Attributed physical-property, hazard, environmental and use annotations.

Color/Form: Cubic crystals, dark gray with metallic sheen Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Gray cubic crystals Source: Hazardous Substances Data Bank (HSDB)

Density: 5.31 at 77 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
Density: 5.3176 @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
Density: Lattice constant 5.6-54 Angstroms; dielectric constant 11.1; intrinsic resistivity @ 300 deg K= 3.7X10+8 ohm-cm; electron lattice mobility @ 300 deg K= 10,000 square cm/volt-sec; intrinsic charge density @ 300 deg K= 1.4X10+6/cc; electron diffusion constant @ 300 deg K= 310 square cm/sec; hole diffusion constant= 11.5 square cm/sec Source: Hazardous Substances Data Bank (HSDB)
Density: 5.31 Source: Occupational Safety and Health Administration (OSHA)

Melting Point: 2260 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 1238 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Melting Point: 1238 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 2260 °F Source: Occupational Safety and Health Administration (OSHA)

Odor: Garlic odor when moistened Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Gallium arsenide is an insoluble, high-boiling solid which may react very slowly with water or water vapor to evolve toxic gases such as arsine. It is used as a high-performance material in the semiconductor industry. Source: CAMEO Chemicals
Physical Description: Gray crystals or powder; [CAMEO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Dark gray crystals with a metallic greenish-blue sheen or gray powder. Source: Occupational Safety and Health Administration (OSHA)

Solubility: less than 1 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: <1 mg/mg in DMSO, 95% ethanol, methanol, and acetone; soluble in hydrochloric acid Source: Hazardous Substances Data Bank (HSDB)
Solubility: In water, <1 mg/ml @ 20 °C Source: Hazardous Substances Data Bank (HSDB)

Substance: Gallium Arsenide Source: NTP Technical Reports
NTP Technical Report: TR-492: Toxicology and Carcinogenesis Studies of Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (2000 ) Source: NTP Technical Reports
Peer Review Date: 05/21/99 Source: NTP Technical Reports
Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
Conclusion for Female Rat: Clear Evidence Source: NTP Technical Reports
Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
Summary: Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenic activity of gallium arsenide in male F344/N rats exposed to 0.01, 0.1, or 1.0 mg/m3. There was clear evidence of carcinogenic activity in female F344/N rats based on increased incidences of benign and malignant neoplasms in the lung. Increased incidences of benign neoplasms of the adrenal medulla and increased incidences of mononuclear cell leukemia were also considered to be exposure related. There was no evidence of carcinogenic activity in male or female B6C3F1 mice exposed to 0.1, 0.5, or 1.0 mg/m3.; Exposure to gallium arsenide caused a spectrum of nonneoplastic lesions in the lung of rats and mice, the larynx of male rats and hyperplasia of the tracheobronchial lymph node in mice. Source: NTP Technical Reports
Carcinogen Classification: 1, carcinogenic to humans. (L135) Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: Oral (L2) ; inhalation (L2); dermal (L2) Source: Toxin and Toxin Target Database (T3DB)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity]; H360F: May damage fertility [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Note: This chemical does not meet GHS hazard criteria for 6.2% (7 of 112) of reports. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H350 (88.4%): May cause cancer [Danger Carcinogenicity]; H360 (50.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H372 (88.4%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 112 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 7 of 112 reports by companies.; There are 6 notifications provided by 105 of 112 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P264, P270, P280, P308+P316, P318, P319, P321, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Health Effects: Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) Source: Toxin and Toxin Target Database (T3DB)

Toxicity Summary: Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) Source: Toxin and Toxin Target Database (T3DB)

Sources/Uses: Used in semiconductor applications; [Merck Index #4347] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: In semiconductor applications (transistors, solar cells, lasers) Source: Hazardous Substances Data Bank (HSDB)
Uses: Semiconductor in light-emitting diodes for telephone dials; magnetoresistance devices; thermistors; microwave generation Source: Hazardous Substances Data Bank (HSDB)
Uses: Infrared emitters; photoelectronic transmission of data by optical fibers Source: Hazardous Substances Data Bank (HSDB)
Uses: Gallium arsenide is used as a semiconductor, as well as in solar cells, x-ray detection diodes, and laser diodes. (L354) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Gallium arsenide

Chemical / IUPAC name

Gallium arsenide

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1B	✓	—	✓

Key data

CAS

1303-00-0

215-114-8

Annex

Entry number

1564

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1563