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Annex II Entry 1561 CMR30/07/2020

Perfluorooctanoic acid

Perfluorooctanoic acid is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1561
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 335-67-1
CAS 335-67-1PubChem CID 9554

Perfluorooctanoic acid

Perfluorooctanoic acid is a fluoroalkanoic acid that is perfluorinated octanoic acid. It has a role as an endocrine disruptor, a surfactant, a xenobiotic, a carcinogenic agent and an environmental contaminant. It is functionally related to an octanoic acid and a perfluorooctane. — ChEBI

IUPAC name
2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoic acid
Molecular formula
C8HF15O2
Molecular weight
414.07 g/mol
Exact mass
413.9737017 Da
XLogP3
4.9
Topological polar surface area
37.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
17
Covalent units
1
Defined stereocentres
0

Also known as

Pentadecafluorooctanoic acidPFOAPerfluorocaprylic acidPerfluoroctanoic acidPerfluoroheptanecarboxylic acidPerfluoro-n-octanoic acidPentadecafluoro-1-octanoic acidPentadecafluoro-n-octanoic acid
16 more reported names
NSC 95114AI3-19341947VD76D3LHexanoyl fluoride, 3,3,4,4,5,5,6,6,6-nonafluoro-2-oxo-NSC-95114CHEBI:35549OCTANOIC ACID, PENTADECAFLUOROPFOA cpdRefChem:6114PFOA perfluorooctanoic acid206-397-9Octanoic acid, pentadecafluoro-C8HF15O2n-perfluorooctanoic acidIPC-PFFA-8 HGperflurooctanoic acid
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Perfluorooctanoic acid

Chemical / IUPAC name

Perfluorooctanoic acid

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓
Cat. 2✓——

Key data

CAS
335-67-1
EC
206-397-9
Annex
II
Entry number
1561

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1564
Nearby record in the same annex

Gallium arsenide

CAS: 1303-00-0
EC: 215-114-8
Annex II 1565
Nearby record in the same annex

Vinyl acetate

CAS: 108-05-4
EC: 203-545-4

What Annex II means for Perfluorooctanoic acid

Perfluorooctanoic acid is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Perfluorooctanoic acid is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 335-67-1 is the unique numerical identifier assigned to Perfluorooctanoic acid by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Perfluorooctanoic acid has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Perfluorooctanoic acid

This page summarizes one Annex II record for Perfluorooctanoic acid from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Perfluorooctanoic acid, but confirm any final regulatory decision against the current official annex wording and source files.

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