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Annex II Entry 151 15/10/2010

Dinitrophenol isomers

Dinitrophenol isomers is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 151

Chemical identity and properties

PubChem 2D chemical structure for CAS 25550-58-7
CAS 25550-58-7PubChem CID 6191

2,3-Dinitrophenol

2,3-dinitrophenol is a dinitrophenol. — ChEBI

IUPAC name
2,3-dinitrophenol
Molecular formula
C6H4N2O5
Molecular weight
184.11 g/mol
Exact mass
184.01202123 Da
XLogP3
1.9
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

66-56-8Phenol, 2,3-dinitro-2,3-DNPNSC-156083735M30625HCHEBI:39354RefChem:81872200-628-7
14 more reported names
2,3-Dinitrofenol [Czech]2,3-DinitrofenolCCRIS 3101EINECS 200-628-7NSC 156083BRN 2213580Phenol,3-dinitro-2,3-Dinitro-phenolWLN: WNR CQ BNW4-06-00-01369 (Beilstein Handbook Reference)UNII-735M30625HAC-24718DB-0197922,3-Dinitrophenol, moistened with water, >=98.0% (HPLC)
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 329-71-5
CAS 329-71-5PubChem CID 9492

2,5-Dinitrophenol

2,5-dinitrophenol is a dinitrophenol having the nitro groups at the 2- and 5-positions. — ChEBI

IUPAC name
2,5-dinitrophenol
Molecular formula
C6H4N2O5
Molecular weight
184.11 g/mol
Exact mass
184.01202123 Da
XLogP3
1.8
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

Phenol, 2,5-dinitro-gamma-Dinitrophenol2,5-DNP2,5-DinitrofenolPhenol, gamma-dinitro-HSD25Q268ZNSC-90441CHEBI:40810
16 more reported names
RefChem:82985206-348-1.gamma.-DinitrophenolPhenol, .gamma.-dinitro-2,5-Dinitrophenol (Wetted with water >20%)2,5-DINITROPHENOL (WETTED WITH CA. 20% WATER) (UNIT WEIGHT ON DRY WEIGHT BASIS)2,5-Dinitrofenol [Czech]CCRIS 3103HSDB 6304EINECS 206-348-1NSC 90441BRN 1913411UNII-HSD25Q268Z2,5-Dinitrophenol ( betta )WLN: WNR BQ DNW2,5-Dinitrophenol, 97%
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 51-28-5
CAS 51-28-5PubChem CID 1493

2,4-Dinitrophenol

2,4-dinitrophenol is a dinitrophenol having the nitro groups at the 2- and 4-positions. It has a role as a geroprotector, an antiseptic drug, an allergen, an oxidative phosphorylation inhibitor and a bacterial xenobiotic metabolite. It is a conjugate acid of a 2,4-dinitrophenol(1-). — ChEBI

IUPAC name
2,4-dinitrophenol
Molecular formula
C6H4N2O5
Molecular weight
184.11 g/mol
Exact mass
184.01202123 Da
XLogP3
1.7
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

AldifenNitropheneDinofanPhenol, 2,4-dinitro-Fenoxyl carbon NSolfo Black BTertrosulphur PBRSolfo Black G
16 more reported names
Nitro kleenup1-Hydroxy-2,4-dinitrobenzene2,4-Dnpalpha-DinitrophenolChemox PESolfo Black BBSolfo Black SBDinitrofenoloTertrosulphur Black PBSolfo Black 2B Supra2,4-DinitrofenolMaroxol-50Osmoplastic-ROsmotox-PlusChemoxMitcal
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 573-56-8
CAS 573-56-8PubChem CID 11312

2,6-Dinitrophenol

2,6-dinitrophenol is a dinitrophenol. — ChEBI

IUPAC name
2,6-dinitrophenol
Molecular formula
C6H4N2O5
Molecular weight
184.11 g/mol
Exact mass
184.01202123 Da
XLogP3
1.4
Topological polar surface area
112.0 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

o-DinitrophenolPhenol, 2,6-dinitro-beta-Dinitrophenol2,6-DNP2,6-DinitrofenolPhenol, beta-dinitro-F4QM4I92KCCHEBI:39357
16 more reported names
NSC-6215RefChem:83353209-357-9.beta.-DinitrophenolDinitro-2,6-phenolPhenol, .beta.-dinitro-2,6-Dinitrofenol [Czech]CCRIS 3104HSDB 6306NSC 6215EINECS 209-357-9UNII-F4QM4I92KCBRN 19134102,6-dinitro phenolWLN: WNR BQ CNWEpitope ID:161741
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External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Dinitrophenol isomers

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS
51-28-5 / 329-71-5 / 573-56-8 / 25550-58-7
EC
200-087-7 / 206-348-1 / 209-357-9 / 247-096-2
Annex
II
Entry number
151

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 150
Nearby record in the same annex

Succinonitrile

CAS: 110-61-2
EC: 203-783-9
Annex II 149
Nearby record in the same annex

Malononitrile

CAS: 109-77-3
EC: 203-703-2

What Annex II means for Dinitrophenol isomers

Dinitrophenol isomers is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. Dinitrophenol isomers is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 51-28-5 / 329-71-5 / 573-56-8 / 25550-58-7 is the unique numerical identifier assigned to Dinitrophenol isomers by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Dinitrophenol isomers

This page summarizes one Annex II record for Dinitrophenol isomers from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Dinitrophenol isomers, but confirm any final regulatory decision against the current official annex wording and source files.

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