What is CAS 110-61-2 for Succinonitrile?

CAS 110-61-2 is the unique numerical identifier assigned to Succinonitrile by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 150 15/10/2010

Succinonitrile

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Succinonitrile is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 150

Chemical identity and properties

PubChem 2D chemical structure for CAS 110-61-2

CAS 110-61-2PubChem CID 8062

Succinonitrile

Succinonitrile appears as colorless to light brown crystals. Colorless waxy solid melting at 57 °C. Highly toxic. — CAMEO Chemicals

IUPAC name: butanedinitrile

Molecular formula: C4H4N2
Molecular weight: 80.09 g/mol
Exact mass: 80.037448136 Da
XLogP3: -1.0
Topological polar surface area: 47.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

1,2-DicyanoethaneDeprelinSuccinodinitrileDinileEthylene cyanideEthylene dicyanideDicianSuxil

16 more reported names

1,4-ButanedinitrileSuccinilDisuxylEvanexs-DicyanoethaneSuccinic acid nitrileSuccinic dinitrileSuccinic acid dinitrileSukcinonitrilsym-DicyanoethaneUSAF A-9442Ethane, 1,2-dicyano-Dicyanoethane1R479O92DONSC-4852RefChem:186355

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1562258
EPA DTXSID:DTXSID9026059
PubMed:22590040
PubMed:21870885
PubMed:21690896
PubMed:21690889
PubMed:21579156
PubMed:21557494
PubMed:21338133
PubMed:20950019
PubMed:20366113
PubMed:19539683
PubMed:19301886
PubMed:19153727

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8062

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 509 to 513 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
Boiling Point: 266 °C Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: Boiling point: 185 °C @ 60 mm Hg; 158-160 @ 20 mm Hg Source: Hazardous Substances Data Bank (HSDB)
Boiling Point: 265 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Boiling Point: 509 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

Color/Form: Colorless waxy solid Source: Hazardous Substances Data Bank (HSDB)

Density: 1.023 at 113 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
Density: 0.9867 g/cu cm @ 60 °C Source: Hazardous Substances Data Bank (HSDB)
Density: 1.02 g/cm³ Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Density: 0.99 Source: The National Institute for Occupational Safety and Health (NIOSH)

Flash Point: 270 °F (NTP, 1992) Source: CAMEO Chemicals
Flash Point: 132 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Flash Point: 270 °F (132 °C) (closed cup) Source: Hazardous Substances Data Bank (HSDB)
Flash Point: 132 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Flash Point: 270 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

LogP: log Kow = -0.99 Source: Hazardous Substances Data Bank (HSDB)
LogP: -0.99 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 135 to 136 °F (NTP, 1992) Source: CAMEO Chemicals
Melting Point: 54.5 °C Source: Hazardous Substances Data Bank (HSDB)
Melting Point: 54 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Melting Point: 134 °F Source: The National Institute for Occupational Safety and Health (NIOSH)

Odor: Odorless Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Succinonitrile appears as colorless to light brown crystals. Colorless waxy solid melting at 57 °C. Highly toxic. Source: CAMEO Chemicals
Physical Description: Colorless, odorless, waxy solid; Note: Forms cyanide in the body; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: COLOURLESS WAXY CRYSTALS. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: Colorless, odorless, waxy solid. [Note: Forms cyanide in the body.] Source: The National Institute for Occupational Safety and Health (NIOSH)

Refractive Index: Index of refraction: 1.4173 D/ 60 °C Source: Hazardous Substances Data Bank (HSDB)

Solubility: 50 to 100 mg/mL at 70 °F (NTP, 1992) Source: CAMEO Chemicals
Solubility: Soluble in acetone, chloroform, dioxane; slightly soluble in ethanol, benzene, ether, carbon sulfide Source: Hazardous Substances Data Bank (HSDB)
Solubility: In water, 126.9 g/L @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in water, g/100ml at 20 °C: 13 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Solubility: 13% Source: The National Institute for Occupational Safety and Health (NIOSH)

Vapor Pressure: 2 mmHg at 392 °F (NTP, 1992) Source: CAMEO Chemicals
Vapor Pressure: 0.00778 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: 1.0382 Pa (0.00778 mm Hg) @ 298.29 K (25.14 °C) (solid) Source: Hazardous Substances Data Bank (HSDB)
Vapor Pressure: (212 °F): 2 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)

Viscosity: 0.002008 kg/m-sec @ 75 °C Source: Hazardous Substances Data Bank (HSDB)

Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: The substance can be absorbed into the body by ingestion and by inhalation. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
Exposure Routes: Oral (L96) ; inhalation (L96) ; dermal (L96) Source: Toxin and Toxin Target Database (T3DB)

First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)

Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (95%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (36.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H315 (53.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (53.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (53.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (35%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (35%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 80 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Health Effects: Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (L96, L97) Source: Toxin and Toxin Target Database (T3DB)

NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)

Target Organs: Eyes, skin, respiratory system, central nervous system, cardiovascular system Source: The National Institute for Occupational Safety and Health (NIOSH)

Toxicity Summary: Organic nitriles decompose into cyanide ions both in vivo and in vitro. Consequently the primary mechanism of toxicity for organic nitriles is their production of toxic cyanide ions or hydrogen cyanide. Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (L97) Source: Toxin and Toxin Target Database (T3DB)

Environmental Bioconcentration: An estimated BCF of 3 was calculated for succinonitrile(SRC), using a log Kow of -0.99(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 28(SRC), determined from a structure estimation method(2), indicates that succinonitrile is expected to have very high mobility in soil(SRC). Volatilization of succinonitrile from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.5X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 0.00778 mm Hg(3), and water solubility, 126.9 g/L(4). Succinonitrile is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.00778 mm Hg(3). In studies with activated sludge, biodegradation of 1.5-3.8% was observed after 6-24 hours(5). These studies suggest that succinonitrile may have been toxic to the microorganisms, since a high concentration of succinonitrile was used(5). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 28(SRC), determined from a structure estimation method(2), indicates that succinonitrile is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6.5X10-9 atm-cu m/mole(SRC), derived from its vapor pressure, 0.00778 mm Hg(4) and water solubility, 126.9 g/L(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow of -0.99(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions(9). In studies with activated sludge, biodegradation of 1.5-3.8% was observed after 6-24 hours(10). These studies suggest that succinonitrile may have been toxic to the microorganisms, since a high concentration of succinonitrile was used(10). Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), succinonitrile, which has a vapor pressure of 0.00778 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. The reaction of vapor-phase succinonitrile with photochemically-produced hydroxyl radicals is not expected to be an important environmental fate based on the estimated half-life for this reaction in air of 380 days, calculated from its rate constant of 4.3X10-14 cu cm/molecule-sec at 25 deg (SRC) that was derived using a structure estimation method(3). Succinonitrile is not expected to be susceptible to direct photolysis by sunlight, since it does not contain functional groups that are expected to absorb light with wavelengths >290 nm(SRC). Source: Hazardous Substances Data Bank (HSDB)

Sources/Uses: Used to make plastics and nitron fibers; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: Used in the production of plastics and nitron fibers. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Succinonitrile

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Key data

CAS

110-61-2

203-783-9

Annex

Entry number

150

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 149