Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5] is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-)
- IUPAC name
- hydron;tris(nickel(2+));hydroxide;disilicate
- Molecular formula
- H4Ni3O9Si2
- Molecular weight
- 380.28 g/mol
- Exact mass
- 379.740853 Da
- Topological polar surface area
- 185.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 9
- Covalent units
- 9
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID601028875
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H350i: May cause cancer by inhalation [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P260, P261, P264, P270, P272, P273, P280, P302+P352, P318, P319, P321, P333+P317, P362+P364, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Dinickel orthosilicate
- IUPAC name
- bis(nickel(2+));silicate
- Molecular formula
- Ni2O4Si
- Molecular weight
- 209.47 g/mol
- Exact mass
- 207.827268 Da
- Topological polar surface area
- 92.2 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID20929885
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Nickel(2+) silicate
- IUPAC name
- nickel(2+) silicate
- Molecular formula
- NiO4Si-2
- Molecular weight
- 150.78 g/mol
- Exact mass
- 149.891927 Da
- Topological polar surface area
- 92.2 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 4
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Silicic acid (H2SiO3), nickel(2+) salt (4:3)
- IUPAC name
- tetrakis(dioxido(oxo)silane);tris(nickel(2+))
- Molecular formula
- Ni3O12Si4-2
- Molecular weight
- 480.41 g/mol
- Exact mass
- 479.648150 Da
- Topological polar surface area
- 253.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 12
- Covalent units
- 7
- Defined stereocentres
- 0
Also known as
External database identifiers
- EPA DTXSID:DTXSID601029304
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
silicic acid, nickel salt
- IUPAC name
- dioxido(oxo)silane;nickel(2+)
- Molecular formula
- NiO3Si
- Molecular weight
- 134.777 g/mol
- Exact mass
- 133.897012 Da
- Topological polar surface area
- 63.2 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 3
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
1 more reported name
External database identifiers
- EPA DTXSID:DTXSID701346345
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
Chemical / IUPAC name
Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1A | ✓ | — | — |
Key data
Related records for Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Dinickel hexacyanoferrate
Trinickel bis(arsenate); nickel(II) arsenate
Nickel oxalate [1]; Oxalic acid, nickel salt [2]
Nickel hydrogen phosphate [1]; Nickel bis(dihydrogen phosphate) [2]; Trinickel bis(orthophosphate) …
Nickel hexafluorosilicate
What Annex II means for Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5] is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Source note for Annex II record Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5]
This page summarizes one Annex II record for Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5] from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5], but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
Check your formula
Paste a full INCI list to detect Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5] and other flagged EU annex records in one pass.
INCI CheckerCompare entries
Compare Nickel(II) silicate [1]; Dinickel orthosilicate [2]; Nickel silicate (3:4) [3]; Silicic acid, nickel salt [4]; Trihydrogen hydroxybis[orthosilicato(4-)]trinickelate(3-) [5] side by side with another annex record to review differences in restrictions, concentrations and annex placement.
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