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Annex II Entry 1391 CMR30/07/2020

Acetaldehyde; ethanal

Acetaldehyde; ethanal is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1391
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 75-07-0
CAS 75-07-0PubChem CID 177

Acetaldehyde

Acetaldehyde is the aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke. It has a role as an electron acceptor, a mutagen, a carcinogenic agent, a teratogenic agent, an oxidising agent, a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an EC 3.5.1.4 (amidase) inhibitor. — ChEBI

IUPAC name
acetaldehyde
Molecular formula
C2H4O
Molecular weight
44.05 g/mol
Exact mass
44.026214747 Da
XLogP3
-0.3
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

ethanalacetic aldehydeethyl aldehydeAcetylaldehydeAcetaldehydAldeide aceticaAcetic ethanolOctowy aldehyd
16 more reported names
Aldehyde acetiqueRCRA waste number U001NSC 7594NCI-C56326FEMA No. 2003GO1N1ZPR3BCHEBI:15343NSC-7594DTXCID202NSC7594Acetaldehyde PhenolicAcetaldehyde 1501RefChem:6606200-836-8ethanoneEthylaldehyde
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Acetaldehyde; ethanal

Chemical / IUPAC name

Acetaldehyde; ethanal

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

SCCS opinions

Identified ingredients

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓——
Cat. 2—✓—

Key data

CAS
75-07-0
EC
200-836-8
Annex
II
Entry number
1391

Inventory links for Acetaldehyde; ethanal

Inventory Restriction reference
Ref 74144

ACETALDEHYDE

CAS: 75-07-0
EC: 200-836-8

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1396
Nearby record in the same annex

Borates, tetraborates, octaborates and boric acid salts and esters, including: Disodium octaborate …

CAS: 12008-41-2 [1]/ 12280-03-4 [2]/ 10377-81-8 [3]/ 68003-13-4 [4]/ 12712-38-8 [5]/ -[6]/ 1332-07-6 [7]/ 1330-43-4 [8]/ 12267-73-1 [9]/ 13840-56-7 [10]/ 1303-96-4 [11]/ 12179-04-3 [12]
EC: 234-541-0 [1]/ 234-541-0 [2]/ 233-829-3 [3]/ 268-109-8 [4]/ 603-184-6 [5]/ -[6]/ 215-566-6 [7]/ 215-540-4 [8]/ 235-541-3 [9]/ 237-560-2 [10]/ 215-540-4 [11]/ 215-540-4 [12]

What Annex II means for Acetaldehyde; ethanal

Acetaldehyde; ethanal is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Acetaldehyde; ethanal is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 75-07-0 is the unique numerical identifier assigned to Acetaldehyde; ethanal by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Acetaldehyde; ethanal has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Acetaldehyde; ethanal

This page summarizes one Annex II record for Acetaldehyde; ethanal from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Acetaldehyde; ethanal, but confirm any final regulatory decision against the current official annex wording and source files.

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