Annex II Entry 1253 21/10/2010

1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts, when used as a substance in hair dye products

Q: How do I check if my product formula contains 1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts, when used as a substance in hair dye products?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1253

Chemical identity and properties

PubChem 2D chemical structure for CAS 108-73-6

CAS 108-73-6PubChem CID 359

Phloroglucinol

Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5. It has a role as an algal metabolite. It is a phenolic donor and a benzenetriol. — ChEBI

IUPAC name: benzene-1,3,5-triol

Molecular formula: C6H6O3
Molecular weight: 126.11 g/mol
Exact mass: 126.031694049 Da
XLogP3: 0.2
Topological polar surface area: 60.7 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

1,3,5-benzenetriol1,3,5-trihydroxybenzenePhloroglucinPhloroglucineSpasfon-LyocDilospan Ssym-Trihydroxybenzenes-Trihydroxybenzene

16 more reported names

Benzene, trihydroxyFloroglucinFloroglucinolDHD7FFG6YSBenezene-1,3,5-triolNSC-1572CHEBI:16204RefChem:6129203-611-2Phloroglucinol anhydrousBenzene-s-triol3,5-Dihydroxyphenol5-Hydroxyresorcinol5-Oxyresorcinol5-Oxyresorcinolphloroglucin1,3,5-THB

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16204
ChEMBL:CHEMBL473159
EPA DTXSID:DTXSID9048354
PubMed:26054450
PubMed:23800587
PubMed:23178381
PubMed:23013382
PubMed:22978662
PubMed:22978223
PubMed:22938149
PubMed:22934600
PubMed:22927079
PubMed:22896828
PubMed:22889530
PubMed:22868169

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match359

Attributed physical-property, hazard, environmental and use annotations.

LogP: 0.16 Source: Human Metabolome Database (HMDB)

Melting Point: 218.5 °C Source: Human Metabolome Database (HMDB)

Physical Description: White solid; Discolored by light; [Merck Index] White or cream colored powder; [MSDSonline] Crystallizes in anhydrous or dihydrate form; Sweet tasting crystals; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: Solid Source: Human Metabolome Database (HMDB)

Solubility: 10.6 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)

Vapor Pressure: 0.00016 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Note: This chemical does not meet GHS hazard criteria for 1.9% (2 of 108) of reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H315 (81.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (41.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (81.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (81.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (11.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H361 (11.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H412 (12%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 108 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 108 reports by companies.; There are 22 notifications provided by 106 of 108 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: On the basis of the available data, the CIR Panel cannot conclude that Phloroglucinol is safe for use in cosmetic products until the appropriate safety data have been obtained and evaluated. Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Ingredients for which the data are insufficient and their use in cosmetics is not supported Source: Cosmetic Ingredient Review (CIR)

Cosmetic Ingredient Review Link: CIR ingredient: Phloroglucinol Source: Cosmetic Ingredient Review (CIR)
Sources/Uses: Used to decalcify bones, to make pharmaceuticals and dyes, to preserve cut flowers, and to dye and print textiles; [Hawley] Used in diazo-type printing, cosmetics (antioxidant), hair colorants, chemical reagents, cloud seeding, tree and shrub rooting, and pharmaceuticals (antispasmodic); [Merck Index] Isolated from bark of fruit trees in 1855; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts, when used as a substance in hair dye products

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

Identified ingredients

PHLOROGLUCINOL

Key data

CAS

108-73-6

203-611-2

Annex

Entry number

1253

Inventory links for 1,3,5-Trihydroxybenzene (Phloroglucinol) and its salts, when used as a substance in hair dye products

Inventory Restriction reference

Ref 36542

PHLOROGLUCINOL

CAS: 108-73-6

EC: 203-611-2

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1252