CAS 108-73-6PubChem CID 359
Phloroglucinol
Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5. It has a role as an algal metabolite. It is a phenolic donor and a benzenetriol. — ChEBI
- IUPAC name
- benzene-1,3,5-triol
- Molecular formula
- C6H6O3
- Molecular weight
- 126.11 g/mol
- Exact mass
- 126.031694049 Da
- XLogP3
- 0.2
- Topological polar surface area
- 60.7 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
1,3,5-benzenetriol1,3,5-trihydroxybenzenePhloroglucinPhloroglucineSpasfon-LyocDilospan Ssym-Trihydroxybenzenes-Trihydroxybenzene
16 more reported names
Benzene, trihydroxyFloroglucinFloroglucinolDHD7FFG6YSBenezene-1,3,5-triolNSC-1572CHEBI:16204RefChem:6129203-611-2Phloroglucinol anhydrousBenzene-s-triol3,5-Dihydroxyphenol5-Hydroxyresorcinol5-Oxyresorcinol5-Oxyresorcinolphloroglucin1,3,5-THB
External database identifiers
- ChEBI:CHEBI:16204
- ChEMBL:CHEMBL473159
- EPA DTXSID:DTXSID9048354
- PubMed:26054450
- PubMed:23800587
- PubMed:23178381
- PubMed:23013382
- PubMed:22978662
- PubMed:22978223
- PubMed:22938149
- PubMed:22934600
- PubMed:22927079
- PubMed:22896828
- PubMed:22889530
- PubMed:22868169
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match359
Attributed physical-property, hazard, environmental and use annotations.
- LogP: 0.16 Source: Human Metabolome Database (HMDB)
- Melting Point: 218.5 °C Source: Human Metabolome Database (HMDB)
- Physical Description: White solid; Discolored by light; [Merck Index] White or cream colored powder; [MSDSonline] Crystallizes in anhydrous or dihydrate form; Sweet tasting crystals; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Solubility: 10.6 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Vapor Pressure: 0.00016 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Note: This chemical does not meet GHS hazard criteria for 1.9% (2 of 108) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (81.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (41.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (81.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (81.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (11.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H361 (11.1%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H412 (12%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 108 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 108 reports by companies.; There are 22 notifications provided by 106 of 108 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Conclusion: On the basis of the available data, the CIR Panel cannot conclude that Phloroglucinol is safe for use in cosmetic products until the appropriate safety data have been obtained and evaluated. Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): Ingredients for which the data are insufficient and their use in cosmetics is not supported Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Link: CIR ingredient: Phloroglucinol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used to decalcify bones, to make pharmaceuticals and dyes, to preserve cut flowers, and to dye and print textiles; [Hawley] Used in diazo-type printing, cosmetics (antioxidant), hair colorants, chemical reagents, cloud seeding, tree and shrub rooting, and pharmaceuticals (antispasmodic); [Merck Index] Isolated from bark of fruit trees in 1855; [Ullmann] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.