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Annex II Entry 1081 CMR21/10/2010

Amitrole (ISO)

Amitrole (ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1081
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 61-82-5
CAS 61-82-5PubChem CID 1639

Amitrole

Amitrole is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties. It has a role as a carotenoid biosynthesis inhibitor, a herbicide and an EC 1.11.1.6 (catalase) inhibitor. It is an aromatic amine and a member of triazoles. — ChEBI

IUPAC name
1H-1,2,4-triazol-5-amine
Molecular formula
C2H4N4
Molecular weight
84.08 g/mol
Exact mass
84.043596145 Da
XLogP3
-0.4
Topological polar surface area
67.6 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

3-amino-1,2,4-triazole1H-1,2,4-Triazol-3-amineAminotriazole3-AminotriazoleAmitrolAmizol3-Amino-1H-1,2,4-triazole3-Amino-s-triazole
16 more reported names
WeedazolAmerolCytrolCytroleEmisolVoroxAzaplantHerbizoleTriazolamineWeedazinWeedoclorAzolanElmasilFenavarAzaplant kombiHerbidal total
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External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Amitrole (ISO)

Chemical / IUPAC name

1,2,4-Triazol-3-ylamine

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2——✓

Key data

CAS
61-82-5
EC
200-521-5
Annex
II
Entry number
1081

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1082
Nearby record in the same annex

Carbaryl (ISO)

CAS: 63-25-2
EC: 200-555-0
Annex II 1078
Nearby record in the same annex

Dieldrin (ISO)

CAS: 60-57-1
EC: 200-484-5
Annex II 1076
Nearby record in the same annex

Acetamide

CAS: 60-35-5
EC: 200-473-5
Annex II 1075
Nearby record in the same annex

Fenarimol (ISO)

CAS: 60168-88-9
EC: 262-095-7
Annex II 1087
Nearby record in the same annex

Fuel oil, no. 2

CAS: 68476-30-2
EC: 270-671-4

What Annex II means for Amitrole (ISO)

Amitrole (ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Amitrole (ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 61-82-5 is the unique numerical identifier assigned to Amitrole (ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Amitrole (ISO) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Amitrole (ISO)

This page summarizes one Annex II record for Amitrole (ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Amitrole (ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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