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Annex II Entry 1076 CMR15/10/2010

Acetamide

Acetamide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1076
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 60-35-5
CAS 60-35-5PubChem CID 178

Acetamide

Acetamide is a member of the class of acetamides that results from the formal condensation of acetic acid with ammonia. It is a member of acetamides, a monocarboxylic acid amide and a N-acylammonia. It is a tautomer of an acetimidic acid. — ChEBI

IUPAC name
acetamide
Molecular formula
C2H5NO
Molecular weight
59.07 g/mol
Exact mass
59.037113783 Da
XLogP3
-0.9
Topological polar surface area
43.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

EthanamideAcetic acid amideMethanecarboxamideAcetimidic acidEthanimidic acidAmid kyseliny octoveNCI-C02108CH3CONH2
16 more reported names
AI3-020608XOE1JSO29NSC 25945NSC-25945DTXCID505FEMA NO. 4251CHEBI:27856CHEBI:49028acetamidoRefChem:108791200-473-5Amide C2Caswell No. 003HAcetimidic acid (VAN)CCRIS 2HSDB 4006
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Acetamide

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
60-35-5
EC
200-473-5
Annex
II
Entry number
1076

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1075
Nearby record in the same annex

Fenarimol (ISO)

CAS: 60168-88-9
EC: 262-095-7
Annex II 1078
Nearby record in the same annex

Dieldrin (ISO)

CAS: 60-57-1
EC: 200-484-5
Annex II 1073
Nearby record in the same annex

Chlordane, pur

CAS: 57-74-9
EC: 200-349-0
Annex II 1072
Nearby record in the same annex

Fenthion (ISO)

CAS: 55-38-9
EC: 200-231-9
Annex II 1081
Nearby record in the same annex

Amitrole (ISO)

CAS: 61-82-5
EC: 200-521-5
Annex II 1082
Nearby record in the same annex

Carbaryl (ISO)

CAS: 63-25-2
EC: 200-555-0

What Annex II means for Acetamide

Acetamide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Acetamide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 60-35-5 is the unique numerical identifier assigned to Acetamide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Acetamide has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Acetamide

This page summarizes one Annex II record for Acetamide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Acetamide, but confirm any final regulatory decision against the current official annex wording and source files.

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