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ProhibitedBinding ruleSAOriginal is EnglishOfficial-source import checked

Aristolochic acid and its salts; Aristolochia spp. and their preparations

Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.

All Saudi Arabia recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Saudi Food and Drug Authority as prohibited in cosmetic products.
Conditions and restrictions
A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.

Substance identity

Official source name
Aristolochic acid and its salts; Aristolochia spp. and their preparations
CAS
475-80-9; 313-67-7; 15918-62-4
EC
Not supplied in this source row
Identity mapping
standalone:official_sfda_record
Search this identity across the siteCAS 475-80-9CAS 313-67-7CAS 15918-62-4

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 15918-62-4
CAS 15918-62-4PubChem CID 167493

Verified chemistry for CAS 15918-62-4

Aristolochic Acid Iv

IUPAC name
8,10-dimethoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Molecular formula
C18H13NO8
Molecular weight
371.3 g/mol
Exact mass
371.06411637 Da
Monoisotopic mass
371.06411637 Da
XLogP3
3.5
Topological polar surface area
120.0 Ų
Molecular complexity
594.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
8
Rotatable bonds
3
Heavy atoms
27
Covalent units
1

Names and synonyms reported to PubChem

O-Methylaristolochic acid D6-Methoxyaristolochic acid DBRN 1332635Aristolochic acid IV(sub a) methyl ether8,10-Dimethoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid2,3-Methylenedioxy-5,7-dimethoxy-10-nitrophenanthroic acidPhenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8,10-dimethoxy-6-nitro-8,10-Dimethoxy-6-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid
8 more reported names
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8,10-dimethoxy-6-nitro-Aristolochate IV8,10-dimethoxy-6-nitronaphtho(2,1-g)(1,3)benzodioxole-5-carboxylic acidRefChem:1140538,10-dimethoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acidL28X6WY7768,10-dimethoxy-6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid6-Nitro-8,10-dimethoxy-phenanthro[3,4-d]-1,3-dioxol-5-carbonsaure
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
14
3D rings
4
3D hydrophobes
0
3D acceptor features
8
3D donor features
0
3D anionic centres
2
3D cationic centres
0
3D conformers
1
Effective 3D rotors
4.6
Machine-readable structure identifiers
SMILES
COC1=CC2=C3C(=C(C=C2C(=C1)OC)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
InChI
InChI=1S/C18H13NO8/c1-24-8-3-10-9(13(4-8)25-2)5-12(19(22)23)15-11(18(20)21)6-14-17(16(10)15)27-7-26-14/h3-6H,7H2,1-2H3,(H,20,21)
InChIKey
GYBINMVKWZEICQ-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 313-67-7
CAS 313-67-7PubChem CID 2236

Verified chemistry for CAS 313-67-7

Aristolochic Acid

Aristolochic acid A is an aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. It has a role as a metabolite, a mutagen, a carcinogenic agent and a nephrotoxin. It is a member of aristolochic acids, a monocarboxylic acid, an aromatic ether, a C-nitro compound, an organic heterotetracyclic compound and a cyclic acetal. — ChEBI

IUPAC name
8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Molecular formula
C17H11NO7
Molecular weight
341.27 g/mol
Exact mass
341.05355169 Da
Monoisotopic mass
341.05355169 Da
XLogP3
3.6
Topological polar surface area
111.0 Ų
Molecular complexity
550.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
7
Rotatable bonds
2
Heavy atoms
25
Covalent units
1

Names and synonyms reported to PubChem

Aristolochic acid AAristolochic acid IAristolochinTardolytAristolochic acid-IARISTOLOCHINETR 1736NSC-50413
16 more reported names
8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acidCHEBI:28258-Methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acidNSC-11926TR-1736Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-8-methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid8-methoxy-6-nitronaphtho(2,1-g)(1,3)benzodioxole-5-carboxylic acid8-methoxy-6-nitrophenanthro(3,4-d)(1,3)dioxole-5-carboxylic acidRefChem:28223206-238-36-methoxy-9-nitro-14,16-dioxatetracyclo(8.7.0.02,7.013,17)heptadeca-1,3,5,7,9,11,13(17)-heptaene-11-carboxylic acidBirthwort
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
13
3D rings
4
3D hydrophobes
0
3D acceptor features
7
3D donor features
0
3D anionic centres
2
3D cationic centres
0
3D conformers
1
Effective 3D rotors
3.6
Machine-readable structure identifiers
SMILES
COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
InChI
InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)
InChIKey
BBFQZRXNYIEMAW-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 475-80-9
CAS 475-80-9PubChem CID 108168

Verified chemistry for CAS 475-80-9

Aristolochic Acid Ii

Aristolochic acid B is an aristolochic acid that is phenanthrene-1-carboxylic acid substituted by a methylenedioxy group at the 3,4 positions and by a nitro group at position 10. It has a role as a metabolite, a mutagen, a carcinogenic agent and a nephrotoxin. It is a member of aristolochic acids, a monocarboxylic acid, an aromatic ether, a C-nitro compound, an organic heterotetracyclic compound and a cyclic acetal. — ChEBI

IUPAC name
6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid
Molecular formula
C16H9NO6
Molecular weight
311.24 g/mol
Exact mass
311.04298701 Da
Monoisotopic mass
311.04298701 Da
XLogP3
3.6
Topological polar surface area
102.0 Ų
Molecular complexity
505.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
6
Rotatable bonds
1
Heavy atoms
23
Covalent units
1

Names and synonyms reported to PubChem

Aristolochic acid BBB72D5PU2YPhenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 6-nitro-6-nitronaphtho(2,1-g)(1,3)benzodioxole-5-carboxylic acidRefChem:283606-nitrophenanthro(3,4-d)-3-dioxole-5-carboxylic acid207-499-6CCRIS 6497
16 more reported names
6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acidAristolochicacidBEINECS 207-499-66-nitrophenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid6-nitro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acidCHEBI:194149HY-N05116-Nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid6-nitronaphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid6-nitro-phenanthro-[3,4-d]-1,3-dioxole-5-carboxylic acidUNII-BB72D5PU2YBRN 0329754MEEXETVZNQYRSP-UHFFFAOYSA-N6-Nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic Acid; Aristolochic Acid II;3,4-(Methylenedioxy)-10-nitrophenanthrene-1-carboxylic Acid;Aristolochic acid _Epitope ID:2157313
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
12
3D rings
4
3D hydrophobes
0
3D acceptor features
6
3D donor features
0
3D anionic centres
2
3D cationic centres
0
3D conformers
1
Effective 3D rotors
2.6
Machine-readable structure identifiers
SMILES
C1OC2=C(O1)C3=C(C(=C2)C(=O)O)C(=CC4=CC=CC=C43)[N+](=O)[O-]
InChI
InChI=1S/C16H9NO6/c18-16(19)10-6-12-15(23-7-22-12)14-9-4-2-1-3-8(9)5-11(13(10)14)17(20)21/h1-6H,7H2,(H,18,19)
InChIKey
MEEXETVZNQYRSP-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Saudi SFDA prohibited and restricted ingredient lists
Source reference
SFDA prohibited list, page 37, row 7
Source record ID
prohibited-36-7
Source version
live-snapshot-2026-08-30
Source language
English
Translation status
Original is English
Snapshot checked
2026-08-30 05:18 UTC
Validation method
complete SFDA paginated HTML snapshot; strict page/row counts
SHA-256
ceb6cc636e6b1f4b3013f88ce0297217b49d6194342c6ece5c03b1e04256d71a

Registered dataset notes

Dataset coverage
Prohibited and restricted substances with CAS, EC and conditions
Authority note
Official SFDA dated lists; version and hash each release
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2090
current Saudi Arabia records
1726
records marked Prohibited
2090
records from this source version
1991
market records with CAS identity

Status distribution

Prohibited: 1726Restricted: 364

Condition text is present on 0 of 2090 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Saudi Arabia market context

Complete official list index

Coverage version: SFDA live prohibited/restricted lists, snapshot 30 August 2026

Every page and entry in the public SFDA prohibited and restricted ingredient indexes; restricted detail pages remain the source for conditions.

Verification checklist

  1. Search names and CAS across both SFDA lists.
  2. Open the cited restricted-entry detail and apply every condition.
  3. Check current SFDA/GSO technical regulations and updates.
  4. Complete eCosma notification, label and responsible-party requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Aristolochic acid and its salts; Aristolochia spp. and their preparations” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Search names and CAS across both SFDA lists.
  3. Open the cited restricted-entry detail and apply every condition.
  4. Check current SFDA/GSO technical regulations and updates.
  5. Complete eCosma notification, label and responsible-party requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textNot present in source row
  • Effective dateNot supplied
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

The record cites SFDA prohibited list, page 37, row 7, source version live-snapshot-2026-08-30. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Aristolochic acid and its salts; Aristolochia spp. and their preparations. SFDA prohibited list, page 37, row 7. Saudi Arabia. Source version live-snapshot-2026-08-30. CosIng Checker regulatory record: https://cosingchecker.com/regulations/sa/records/9966/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Saudi Arabia

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: live-snapshot-2026-08-30

What it does not prove

No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source