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ProhibitedBinding ruleKRNo English translationOfficial-source import checked

히요시아민, 그 염류 및 유도체

Listed by the Korean MFDS as a substance that may not be used in cosmetics.

All South Korea recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Conditions and restrictions
히요시아민

Substance identity

Official source name
히요시아민, 그 염류 및 유도체
CAS
101-31-5
EC
Not supplied in this source row
Identity mapping
standalone:official_korean_name
Search this identity across the siteCAS 101-31-5

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 101-31-5
CAS 101-31-5PubChem CID 154417

Verified chemistry for CAS 101-31-5

Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (alphaS)-

(S)-atropine is an atropine with a 2S-configuration. It is functionally related to a (S)-tropic acid. It is a conjugate base of a (S)-atropinium. — ChEBI

IUPAC name
[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate
Molecular formula
C17H23NO3
Molecular weight
289.4 g/mol
Exact mass
289.16779360 Da
Monoisotopic mass
289.16779360 Da
XLogP3
1.8
Topological polar surface area
49.8 Ų
Molecular complexity
353.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
4
Rotatable bonds
5
Heavy atoms
21
Covalent units
1

Names and synonyms reported to PubChem

Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)-Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (alphaS)-BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-, (3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, (.ALPHA.S)-RefChem:562898Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, (.alpha.S)-Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, (alphaS)-hyoscyamineL-Hyoscyamine
16 more reported names
Daturine(-)-HyoscyamineDuboisine(-)-AtropineL-Tropine tropate(S)-(-)-HyoscyamineCystospazl-Atropine(S)-AtropineHyoscyamine (L)LevsinBellafolineHyoscyaminumAtropine, (s)-ENDO-ATROPINETropine, (-)-tropate
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
3
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
6
3D rings
2
3D hydrophobes
0
3D acceptor features
2
3D donor features
1
3D anionic centres
0
3D cationic centres
1
3D conformers
10
Effective 3D rotors
6.2
Machine-readable structure identifiers
SMILES
CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)[C@H](CO)C3=CC=CC=C3
InChI
InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16-/m1/s1
InChIKey
RKUNBYITZUJHSG-VFSICIBPSA-N

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:17486

(S)-atropine

An atropine with a 2S-configuration.

Formula
C17H23NO3
Average mass
289.375 g/mol
Monoisotopic mass
289.16779 Da
Formal charge
0
  • tropan-3α-yl 3-hydroxy-2-phenylpropanoate — is a (CHEBI:78734)
  • (S)-tropic acid — has functional parent (CHEBI:30766)
  • tropan-3α-yl 3-hydroxy-2-phenylpropanoate — is a (CHEBI:78734)
  • (S)-atropinium — is conjugate base of (CHEBI:58164)
Additional curated names
(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoatetropan-3alpha-yl (2S)-3-hydroxy-2-phenylpropanoate[3(S)-endo]-alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester(-)-atropineDaturineDuboisinel-hyoscyamine(-)-hyoscyaminehyoscyamine(S)-(-)-hyoscyamineL-HyoscyamineL-Tropine tropatetropine, (-)-tropate
Cross-references from this source
  • CAS: 101-31-5 — KEGG COMPOUND
  • CAS: 101-31-5 — ChemIDplus
  • CAS: 101-31-5 — NIST Chemistry WebBook
  • MANUAL_X_REF: 1402 — DrugCentral
  • MANUAL_X_REF: C00002293 — KNApSAcK
  • MANUAL_X_REF: C02046 — KEGG COMPOUND
  • MANUAL_X_REF: D00147 — KEGG DRUG
  • MANUAL_X_REF: DB00424 — DrugBank
  • MANUAL_X_REF: OIN — PDBeChem
  • REGISTRY_NUMBER: 91259 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-22. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match154417

Attributed physical-property, hazard, environmental and use annotations.

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
South Korea MFDS cosmetic ingredient data
Source reference
화장품 안전기준 등에 관한 규정, 별표 1, record 1-1280
Source record ID
1-1280
Source version
2026-19
Source language
Korean
Translation status
No English translation
Effective date
2026-03-18
Source updated
2026-03-18
Snapshot checked
2026-08-30 04:33 UTC
Validation method
MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8

Registered dataset notes

Dataset coverage
Ingredient identity and separate restriction/regulation data endpoints
Authority note
Korean source is canonical; English materials alone are not complete enough for certification
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1320
current South Korea records
1077
records marked Prohibited
1320
records from this source version
1252
market records with CAS identity

Status distribution

Prohibited: 1077Restricted: 243

Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

South Korea market context

Complete current appendix dataset

Coverage version: MFDS Notice 2026-19, effective 18 March 2026

All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.

Verification checklist

  1. Match the Korean canonical substance name and identifiers.
  2. Review all Appendix 1 and 2 matches and conditions.
  3. Check functional-cosmetic and positive-list requirements where applicable.
  4. Confirm current MFDS notice, responsible seller and label obligations.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “히요시아민, 그 염류 및 유도체” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Match the Korean canonical substance name and identifiers.
  3. Review all Appendix 1 and 2 matches and conditions.
  4. Check functional-cosmetic and positive-list requirements where applicable.
  5. Confirm current MFDS notice, responsible seller and label obligations.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

The record cites 화장품 안전기준 등에 관한 규정, 별표 1, record 1-1280, source version 2026-19. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

히요시아민, 그 염류 및 유도체. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-1280. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/1885/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for South Korea

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: 2026-19
  • Effective date: 2026-03-18

What it does not prove

Korean source wording is canonical and other positive lists/notices may still apply to the formulation.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source