1-클로로-2,3-에폭시프로판
Listed by the Korean MFDS as a substance that may not be used in cosmetics.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- Listed by the Korean MFDS as a substance that may not be used in cosmetics.
- Conditions and restrictions
- A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. Open the cited source and apply the market-wide requirements below.
Substance identity
- Official source name
- 1-클로로-2,3-에폭시프로판
- CAS
- 106-89-8
- EC
- 203-439-8
- Identity mapping
- cas_number
- Linked ingredient
- EPICHLOROHYDRIN
Linked CosIng identity data
Names and aliases
CosIng description: 1-Chloro-2,3-epoxypropane,Glycidyl chloride,Oxirane, 2-(chloromethyl)-
EU inventory restriction note: II/657 CMR 1B
Recorded cosmetic function: NOT REPORTED
Function pages:NOT REPORTED
View the complete ingredient profileCross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordCanada
1 linked record · 1 with specific conditions
Open supporting recordNew Zealand
1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
Current record1 linked record
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 106-89-8
Epichlorohydrin
Epichlorohydrin is an epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine. It is an epoxide and an organochlorine compound. It is functionally related to a 1,2-epoxypropane. — ChEBI
- IUPAC name
- 2-(chloromethyl)oxirane
- Molecular formula
- C3H5ClO
- Molecular weight
- 92.52 g/mol
- Exact mass
- 92.0028925 Da
- Monoisotopic mass
- 92.0028925 Da
- XLogP3
- 0.5
- Topological polar surface area
- 12.5 Ų
- Molecular complexity
- 37.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Rotatable bonds
- 1
- Heavy atoms
- 5
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:37144
- ChEMBL:CHEMBL1421613
- EPA DTXSID:DTXSID1020566
- PubMed:29792945
- PubMed:25622337
- PubMed:24211530
- PubMed:23082668
- PubMed:23071914
- PubMed:23044099
- PubMed:23032779
- PubMed:23020247
- PubMed:22971580
- PubMed:22954965
- PubMed:22922194
- PubMed:22875418
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 1
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 1
- 3D rings
- 0
- 3D hydrophobes
- 0
- 3D acceptor features
- 1
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 6
- Effective 3D rotors
- 1.6
Machine-readable structure identifiers
- SMILES
C1C(O1)CCl- InChI
InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2- InChIKey
BRLQWZUYTZBJKN-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
epichlorohydrin
An epoxide that is 1,2-epoxypropene in which one of the methyl hydrogens is substituted by chlorine.
- Formula
- C3H5ClO
- Average mass
- 92.525 g/mol
- Monoisotopic mass
- 92.00289 Da
- Formal charge
- 0
- organochlorine compound — is a (CHEBI:36683)
- epoxide — is a (CHEBI:32955)
- 1,2-epoxypropane — has functional parent (CHEBI:38685)
- organochlorine compound — is a (CHEBI:36683)
- epoxide — is a (CHEBI:32955)
Additional curated names
Cross-references from this source
- CAS: 106-89-8 — ChemIDplus
- CAS: 106-89-8 — KEGG COMPOUND
- CAS: 106-89-8 — NIST Chemistry WebBook
- CAS: 13403-37-7 — NIST Chemistry WebBook
- CAS: 13403-37-7 — ChemIDplus
- REGISTRY_NUMBER: 164180 — Gmelin
- REGISTRY_NUMBER: 79785 — Beilstein
- REGISTRY_NUMBER: 79785 — Reaxys
- MANUAL_X_REF: 1733 — PPDB
- MANUAL_X_REF: c0077 — UM-BBD
- MANUAL_X_REF: C14449 — KEGG COMPOUND
- MANUAL_X_REF: Epichlorohydrin — Wikipedia
- MANUAL_X_REF: HMDB0034232 — HMDB
- MANUAL_X_REF: US2011054197 — Patent
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2026-08-08. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 772 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 772 °F (411 °C) Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 385 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 241.7 °F at 760 mmHg (EPA, 1998) Source: CAMEO Chemicals
- Boiling Point: 117.9 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 116 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 242 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 117.9 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 242 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.18 to 1.801 at 68 °F (EPA, 1998) Source: CAMEO Chemicals
- Density: 1.1750 at 25 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 1.2 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 1.18 Source: Occupational Safety and Health Administration (OSHA)
- Density: 1.175 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 1.18 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 93 °F (EPA, 1998) Source: CAMEO Chemicals
- Flash Point: 88 °F Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 88 °F (31 °C) (Closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 31 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 93 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 93 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: log Kow = 0.45 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 0.45 Source: Human Metabolome Database (HMDB)
- LogP: 0.26 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -54.4 to -14.1 °F (EPA, 1998) Source: CAMEO Chemicals
- Melting Point: -25.6 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -57.2 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -48 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -54 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -25.6 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -54 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Odor is sweet, pungent or chloroform-like ... generally perceived as a slightly irritating chloroformlike odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Pungent, garlic-like odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 1-chloro-2,3-epoxypropane appears as a clear colorless liquid with an irritating chloroform-like odor. Density 9.8 lb / gal. Flash point 87 °F. Polymerizable. If polymerization takes place inside a closed container, the container is subject to violent rupture. Irritates the skin and respiratory system. Toxic by ingestion. A confirmed carcinogen. Vapors heavier than air. Used to make plastics and as a solvent. Source: CAMEO Chemicals
- Physical Description: Liquid; Gas Vapor; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid with a slightly irritating, chloroform-like odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Colorless liquid with a slightly irritating, chloroform-like odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless liquid with a slightly irritating, chloroform-like odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction: 1.44195 at 11.6 °C/D; 1.43969 at 16 °C/D; 1.43585 at 25 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 50 to 100 mg/mL at 72 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Miscible with most organic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with alcohol, ether, chloroform, trichloroethylene, carbon tetrachloride; immiscible with petroleum hydrocarbons. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 6.59X10+4 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 65.9 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml at 20 °C: 6 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: 7% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 10 mmHg at 61.88 °F (EPA, 1998) Source: CAMEO Chemicals
- Vapor Pressure: 16.4 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 16.4 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 1.6 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 13 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 16.4 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 13 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 0.0103 poise at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Epichlorohydrin Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 2A: Probably carcinogenic to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 11: (1976) Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print); Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1999 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1998 Source: International Agency for Research on Cancer (IARC)
- Additional information: NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data Source: International Agency for Research on Cancer (IARC)
- Exposure Routes: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: Warning: Effects may be delayed for several hours. Caution is advised.; Signs and Symptoms of Acute Epichlorohydrin Exposure: Acute exposure to epichlorohydrin may result in nausea, vomiting, and abdominal pain. Liver and kidney effects may be observed. The respiratory tract may become irritated, dyspnea (shortness of breath) may occur, and in acute cases, respiratory paralysis has been observed. Central nervous system and respiratory depression have been noted. Facial swelling, mucosal irritation, dermatitis (red, inflamed skin), and eye irritation may also occur following exposure to epichlorohydrin.; Emergency Life-Support Procedures: Acute exposure to epichlorohydrin may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.; Inhalation Exposure:; 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to epichlorohydrin.; 2. Ev Source: CAMEO Chemicals
- ERG2024, Guide 131P (Epichlorohydrin): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H350: May cause cancer [Danger Carcinogenicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P270, P271, P272, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P318, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1920) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H301+H311+H331 (11.5%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301+H331 (23%): Toxic if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]; H301 (> 99.9%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (> 99.9%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (49.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H330 (23.1%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H331 (76.9%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H350 (99.9%): May cause cancer [Danger Carcinogenicity]; H361 (17.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361f (15.5%): Suspected of damaging fertility [Warning Reproductive toxicity]; H412 (27.3%): Harmful to aquatic life with long lasting effects [Hazardous to the aq Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P318, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1920 reports by companies from 30 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1920 reports by companies.; There are 29 notifications provided by 1919 of 1920 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P320, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
- NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 2 - Materials that readily undergo violent chemical changes at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Specific Notice: W - No water: Materials that react violently or explosively with water. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Respiratory Source: EPA Integrated Risk Information System (IRIS)
- Target Organs: Eyes, skin, respiratory system, kidneys, liver, reproductive system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Toxicity Summary: IDENTIFICATION: Epichlorohydrin is a colorless liquid in which the vapor forms explosive mixtures in air. Phosgene, hydrogen chloride and carbon monoxide are liberated while burning. Acids, caustic solutions and halide salts initiate polymerization reactions. The compound is very reactive with metals such as zinc, aluminum, anhydrous metal halides, strong acids and bases along with alcohol containing materials. In the presence of moisture epichlorohydrin is corrosive to steel. Epichlorohydrin has a chloroform like odor. It is soluble in water. Epichlorohydrin is used for the manufacture of glycerine and unmodified epoxyresins. It is also used in the production of elastomers, glycidil ether, cross linked food starch, wet strength resins for the paper industry, water treatment resins, surfactants, ion exchange resins, plasticizers, dyestuffs, pharmaceutical products, emulsifiers, lubricants and adhesives. HUMAN EXPOSURE: On the basis of use patterns and the chemical and physical properties of epichlorohydrin, human exposure is mainly occupational, through vapor inhalation, direct skin contact and a slight exposure resulting from food consumption. Five human volunteers showed signific Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated for epichlorohydrin(SRC), using a log Kow of 0.45(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.45(2) and a regression-derived equation(3), indicates that epichlorohydrin is expected to have very high mobility in soil(SRC). Volatilization of epichlorohydrin from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), calculated from a vapor pressure of 16.4 mm Hg(4) and water solubility of 65,900 mg/L(5). The potential for volatilization of epichlorohydrin from dry soil surfaces may exist based upon the vapor pressure(4). Epichlorohydrin may undergo hydrolysis in moist soil surfaces based on a hydrolysis half-life of 8.2 days in distilled water(6). Epichlorohydrin achieved 3% of the theoretical BOD in a sewage sludge over a 5 day incubation period, but achieved 14% of the theoretical BOD following acclimation(7), suggesting that biodegradation in acclimated soils may be important(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.45(2) and a regression-derived equation(3), indicates that epichlorohydrin is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.0X10-5 atm-cu m/mole(SRC), calculated from its vapor pressure of 16.4 mm Hg(4) and water solubility of 65,900 mg/L(5). Using this estimated Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 19 hours and 12 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low. The hydrolysis half-life of epichlorohydrin is 8.2 days in distilled water and 5.3 days in simulated seawater(8). Epichlorohydrin achieved 3% of the theoretical BOD in a sewage sludge over a 5 day incubation period, but achieved 14% of the theoretical BOD following acclimation(9); thus biodegradation in acclimated water may be important(S Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), epichlorohydrin, which has a vapor pressure of 16.4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase epichlorohydrin is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 36 days(SRC), calculated from its rate constant of 4.4X10-13 cu cm/molecule-sec at 25 °C(3). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Flocculating agent; Adhesion/cohesion promoter; Intermediate; Monomers Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Filler; Not Known or Reasonably Ascertainable; Stabilizing agent; Intermediate; Flocculating agent; Monomers; Processing aids not otherwise specified Source: EPA Chemical Data Reporting (CDR)
- Uses: The primary use of epichlorohydrin is in the production of epoxy resins used in coatings, adhesives, and plastics. Epichlorohydrin is also used in the manufacture of synthetic glycerine, textiles, paper, inks and dyes, solvents, surfactants, and pharmaceuticals. Source: EPA Hazardous Air Pollutants
- Sources/Uses: Used primarily in the manufacture of epoxy and phenoxy resins; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Semiconductor Manufacturing [Category: Industry]; Painting (Pigments, Binders, and Biocides) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: PRODUCT PROFILE: Epichlorohydrin: Epichlorohydrin (ECH) is mainly used in epoxy resins, which account for up to 75% of output. Synthetic glycerine is an ECH 'sink' allowing integrated players to use spare capacity to run synthetic glycerine plants independently of the natural glycerine market, and exit or substitute the natural product whenever epoxy demand requires. Glycerine can run to 10-15% of demand while other end uses, such as water and paper treatment resins, and elastomers, account for the remainder. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Insect fumigant /Former US/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: Solvent for natural and synthetic resins, gums, cellulose esters and ethers, paints, varnishes, nail enamels and lacquers, cement for celluloid Source: Hazardous Substances Data Bank (HSDB)
- Uses: Raw material for a number of glycerol and glycidol derivatives Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for EPICHLOROHYDRIN (24 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- South Korea MFDS cosmetic ingredient data
- Source reference
- 화장품 안전기준 등에 관한 규정, 별표 1, record 1-915
- Source record ID
1-915- Source version
- 2026-19
- Source language
- Korean
- Translation status
- No English translation
- Effective date
- 2026-03-18
- Source updated
- 2026-03-18
- Snapshot checked
- 2026-08-30 04:33 UTC
- Validation method
- MFDS JSON appendices 1–2 parse; 1077 prohibited, 243 restricted
- SHA-256
056de35b843a5e31f709073f9e79d5e6e18f7c9164eb537bb099b185a37ef7d8
Registered dataset notes
- Dataset coverage
- Ingredient identity and separate restriction/regulation data endpoints
- Authority note
- Korean source is canonical; English materials alone are not complete enough for certification
How this record fits the market dataset
Status distribution
Condition text is present on 638 of 1320 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
South Korea market context
Complete current appendix dataset
Coverage version: MFDS Notice 2026-19, effective 18 March 2026
All rows in official Appendix 1 (prohibited) and Appendix 2 (restricted) of the Safety Standards for Cosmetics.
Verification checklist
- Match the Korean canonical substance name and identifiers.
- Review all Appendix 1 and 2 matches and conditions.
- Check functional-cosmetic and positive-list requirements where applicable.
- Confirm current MFDS notice, responsible seller and label obligations.
Official market sources
- South Korea MFDS cosmetic ingredient dataKorean source is canonical; English materials alone are not complete enough for certification
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “1-클로로-2,3-에폭시프로판” and every CAS/EC identifier refer to the material in your supplier specification.
- Match the Korean canonical substance name and identifiers.
- Review all Appendix 1 and 2 matches and conditions.
- Check functional-cosmetic and positive-list requirements where applicable.
- Confirm current MFDS notice, responsible seller and label obligations.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECAvailable
- Separate condition textNot present in source row
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
1-클로로-2,3-에폭시프로판. 화장품 안전기준 등에 관한 규정, 별표 1, record 1-915. South Korea. Source version 2026-19. CosIng Checker regulatory record: https://cosingchecker.com/regulations/kr/records/1566/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for South Korea
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: 2026-19
- Effective date: 2026-03-18
What it does not prove
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source