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2-Amino-6- chloro-4- nitrophenol (CAS No. 6358-09-4)

IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.

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Regulatory decision and full conditions

Status
Restricted
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex B permits this ingredient only subject to the stated fields of use, limits, requirements and label warnings.
Conditions and restrictions
Field of application/use: a)Hair dye substance in oxidative hair dye products (b) Hair dye substance in non- oxidative hair dye products | Maximum authorised concentration: (b) 2.0 percent | Other limitations/requirements: a)After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2.0 percent. | Label conditions/warnings: a)To be printed on the label: The mixing ratio. ‘Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever experienced any reaction after colouring your hair 3)you have experienced a reaction to a temporary “black henna” tattoo in the past. b)Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “black henna” tattoos may increase your risk of allergy. Do not colour your hair, if: 1)you have a rash on your face or sensitive, irritated and damaged scalp 2)you have ever has experienced any reaction after colouring your hair; and 3)you have experienced a reaction to a temporary “black henna” tattoo in the past.

Substance identity

Official source name
2-Amino-6- chloro-4- nitrophenol (CAS No. 6358-09-4)
CAS
6358-09-4
EC
228-762-1
Identity mapping
cas_number
Linked ingredient
2-AMINO-6-CHLORO-4-NITROPHENOL
Search this identity across the siteCAS 6358-09-4EC 228-762-1

Linked CosIng identity data

Names and aliases

2-AMINO-6-CHLORO-4-NITROPHENOL

CosIng description: 2-amino-6-chloro-4-nitrophenol

EU inventory restriction note: III/252

Recorded cosmetic function: HAIR DYEING

Function pages:HAIR DYEING

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

8 market datasets
PubChem 2D chemical structure for CAS 6358-09-4
CAS 6358-09-4PubChem CID 4679699

Verified chemistry for CAS 6358-09-4

2-Amino-6-Chloro-4-Nitrophenol

IUPAC name
2-amino-6-chloro-4-nitrophenol
Molecular formula
C6H5ClN2O3
Molecular weight
188.57 g/mol
Exact mass
187.9988697 Da
Monoisotopic mass
187.9988697 Da
XLogP3
1.5
Topological polar surface area
92.1 Ų
Molecular complexity
184.0
Formal charge
0
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Rotatable bonds
0
Heavy atoms
12
Covalent units
1

Names and synonyms reported to PubChem

Phenol, 2-amino-6-chloro-4-nitro-6-Chloro-4-nitro-2-aminophenol0ZLP5I1TMCRODOL 9R BASECOLOREX 2A6C4NPRefChem:85305228-762-12-Amino-4-nitro-6-chlorophenol
16 more reported names
2-amino-6-chloro-4-nitro-phenol3-Chloro-2-hydroxy-5-nitroaniline4-nitro-6-chloro-2-aminophenol6358-04-96-CHLORO-2-AMINO-4-NITRO PHENOLEINECS 228-762-12-AMINO-4-NITRO-6-CHLORO PHENOLUNII-0ZLP5I1TMCTWLMSPNQBKSXOP-UHFFFAOYSA-NTox21_303798CS-W016775AC-11375AS-13545CAS-6358-09-4DB-054504DB-263830
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
7
3D rings
1
3D hydrophobes
0
3D acceptor features
2
3D donor features
2
3D anionic centres
1
3D cationic centres
1
3D conformers
1
Effective 3D rotors
1.0
Machine-readable structure identifiers
SMILES
C1=C(C=C(C(=C1N)O)Cl)[N+](=O)[O-]
InChI
InChI=1S/C6H5ClN2O3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H,8H2
InChIKey
TWLMSPNQBKSXOP-UHFFFAOYSA-N

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex B, entry 229
Source record ID
annex-b:229
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
317
records marked Restricted
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “2-Amino-6- chloro-4- nitrophenol (CAS No. 6358-09-4)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record. Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

If this row does not reproduce conditions, open the cited official detail because omission does not mean unrestricted use. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex B, entry 229, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

2-Amino-6- chloro-4- nitrophenol (CAS No. 6358-09-4). IS 4707 (Part 2):2025 Annex B, entry 229. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/16441/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This substance is not unrestricted: cosmetic use is subject to the conditions in the cited official record.

Check product type, body area, concentration, purity and warning requirements before deciding whether a formulation is compliant.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Restricted
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source