CosIng Checker
CosIng Checker
EU cosmetic ingredients, restrictions and safety
Login
ProhibitedBinding ruleINOriginal is EnglishOfficial-source import checked

Tetrachloroethylene (CAS No. 127-18-4)

IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.

All India recordsCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Prohibited
Legal role
Binding rule
Regulatory summary
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Conditions and restrictions
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.

Substance identity

Official source name
Tetrachloroethylene (CAS No. 127-18-4)
CAS
127-18-4
EC
Not supplied in this source row
Identity mapping
standalone:official_bis_record
Search this identity across the siteCAS 127-18-4

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

10 market datasets
PubChem 2D chemical structure for CAS 127-18-4
CAS 127-18-4PubChem CID 31373

Verified chemistry for CAS 127-18-4

Tetrachloroethylene

IUPAC name
1,1,2,2-tetrachloroethene
Molecular formula
C2Cl4
Molecular weight
165.8 g/mol
Exact mass
165.872461 Da
Monoisotopic mass
163.875411 Da
XLogP3
3.4
Topological polar surface area
0.0 Ų
Molecular complexity
55.0
Formal charge
0
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Rotatable bonds
0
Heavy atoms
6
Covalent units
1

Names and synonyms reported to PubChem

TetrachloroethenePerchloroethyleneTetrachlorethylenePercPerchlorethyleneEthene, tetrachloro-Ethylene tetrachloride1,1,2,2-Tetrachloroethylene
16 more reported names
AnkilostinDidakenePercleneTetracapTetropilTetraguerTetralenoPerawinTetralexTetlenTetrachloraethenPerSecCarbon bichloridePercloroetileneTetracloroetenePERK
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
0
3D rings
0
3D hydrophobes
0
3D acceptor features
0
3D donor features
0
3D anionic centres
0
3D cationic centres
0
3D conformers
1
Effective 3D rotors
0.0
Machine-readable structure identifiers
SMILES
C(=C(Cl)Cl)(Cl)Cl
InChI
InChI=1S/C2Cl4/c3-1(4)2(5)6
InChIKey
CYTYCFOTNPOANT-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31373

Attributed physical-property, hazard, environmental and use annotations.

  • Autoignition Temperature: Not flammable (USCG, 1999) Source: CAMEO Chemicals
  • Autoignition Temperature: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Use water spray to reduce vapors; do not put water directly on leak, spill area or inside container. Keep combustibles (wood, paper, oil, etc.) away from spilled material. SMALL SPILL: Cover with DRY earth, DRY sand or other non-combustible material followed with plastic sheet to minimize spreading or contact with rain. Use clean, non-sparking tools to collect material and place it into loosely covered plastic containers for later disposal. Prevent entry into waterways, sewers, basements or confined areas. Source: Hazardous Substances Data Bank (HSDB)
  • Autoignition Temperature: > 650 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • ERG2024, Guide 160 (Perchloroethylene): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • ERG2024, Guide 160 (Tetrachloroethylene): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H351: Suspected of causing cancer [Warning Carcinogenicity]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (46.7%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (45.3%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (45.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336 (45.5%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H351 (99.8%): Suspected of causing cancer [Warning Carcinogenicity]; H411 (100%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 574 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H362: May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P263, P264, P264+P265, P270, P271, P280, P302+P352, P304+P340, P305+P351+P338, P308+P316, P317, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]; H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P280, P301+P316, P301+P330+P331, P302+P317, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P308+P316, P316, P318, P319, P321, P331, P337+P317, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Tetrachloroethylene is a central nervous system depressant. It is also known to cause liver and kidney damage, and is a probably carcinogen. (L116) Source: Toxin and Toxin Target Database (T3DB)
  • Toxicity Summary: IDENTIFICATION AND USE: Teterachloroethylene (PCE) is a colorless liquid. It is used in the textile industry for dry-cleaning and for processing and finishing. PCE is used in both cold cleaning and vapor degreasing of metals, it is also used as a chemical intermediate in the synthesis of fluorocarbons, and as a heat-exchange fluid. It is used as anthelmintic in veterinary medicine. HUMAN STUDIES: Potential symptoms of overexposure are irritation of eyes, nose and throat, nausea, flushing of face and neck, vertigo, dizziness, incoordination, headache, somnolence, skin erythema, and liver damage. Liver and kidney toxicity have been reported as effects of acute exposures to very high doses. In dry cleaners chronically exposed to PCE, increased levels of markers of early renal damage or dysfunction were attributed to the exposure. In children, estimated intakes of 1.6-4.8 g/kg bw have produced vomiting, gastrointestinal bleeding, shock, and even death in one case. Epidemiology studies suggest that the risk of epilepsy and certain types of cancer such as cervical cancer may be increased among adults who were exposed to PCE-contaminated drinking water exposure during gestation and early Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Tetrachloroethylene is believed to affect the central nervous system by altering the fatty acid pattern of brain phospholipids and amino acids, or being incorporated into brain membranes, which may alter neural conduction velocity. Tetrachloroethylene's liver toxicity is caused mainly by its metabolite, trichloroacetic acid (TCA), which induces hepatocellular peroxisomes, causing DNA damage and leading to liver cancer. It is also thought to interfere specifically with energy-dependent hepatic transport functions by inhibiting cell membrane ATPases and decreasing hepatocyte ATP levels. (L116, A63) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: The BCF of tetrachloroethylene in rainbow trout (Salmo gairdneri) was 39.6(1). The BCF for bluegill sunfish (Lepomis macrochirus) was 49(2). BCFs of 28.4-75.7 and 25.8-77.1 were measured in carp (Cyprinus carpio) which were exposed to respective concentrations of 0.01 and 0.1 ppm of tetrachloroethylene over an 8-week period(3). A log BCF 1.69 was reported for bluegill sunfish (Lepomis macrochirus) and a log BCF range of 1.59-2.06 for rainbow trout (Salmo gairdneri)(4), corresponding to BCFs of 49 and 36-115, respectively(SRC). According to a classification scheme(5), BCF values of 0-30 are low and from 100-1000 are high. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: The bioconcentration factor for tetrachloroethylene analyzed at different exposure concentrations in dab (Limanda limanda) was as follows(1):; Table: Accumulation Factors [Table#367] Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values in the range of 200-237(2-4) indicate that tetrachloroethylene is expected to have moderate mobility in soil(SRC). Volatilization of tetrachloroethylene from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 0.0177 atm-cu m/mole(5). Tetrachloroethylene may volatilize from dry soil surfaces based on a vapor pressure of 18.5 mm Hg at 25 °C(6). Volatilization half-lives in the range of 1.2-5.4 hrs were measured for tetrachloroethylene from a sandy loam soil surface and volatilization half-lives of 1.9-5.2 hrs were measured from an organic topsoil(7). Using soil microcosms (60% municipal solid, 40% bulk, industrial, and sewage treatment sludge), tetrachloroethylene, present at 5 ug/L, exhibited no degradation when incubated at 20 °C(8) indicating that biodegradation is not a fast environmental fate process in soil(SRC). There is evidence that slow biodegradation of tetrachloroethylene occurs under anaerobic conditions when the microorganisms have been acclimated, yielding trichloroethylene as a product(9,10). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), measured Koc values of 200-237(2-4), indicate that tetrachloroethylene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(5) based upon a Henry's Law constant of 0.0177 atm-cu m/mole(6). Using this Henry's Law constant and an estimation method(5), volatilization half-lives for a model river and model lake are 4 hours and 5 days, respectively(SRC). Measured hydrolysis half-lives of 9 months to 3.34X10+11 years indicate hydrolysis is not an environmentally relevant process(7). According to a classification scheme(8), BCFs of 26-115(7, 9-11) measured in fish, suggest bioconcentration in aquatic organisms is low to high. Tetrachloroethylene may undergo indirect photolysis in natural waters when photosensitizers such as humic acids are present(12). This process is only expected to be important in sunlit surface waters containing humic material. The biodegradation half-lives of tetrachloroethylene in aerobic and anaerobic waters were reported as 180 and 98 days, respectively(13). In anaerobic microcosms established with surface sediments from tidal flats, tetrachloroethylene dechlo Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetrachloroethylene, which has a vapor pressure of 18.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetrachloroethylene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 96 days(SRC), calculated from its rate constant of 1.67X10-13 cu cm/molecule-sec at 25 °C(3). Tetrachloroethylene may also be degraded in the atmosphere by reaction with ozone, but the rate of this reaction is too slow to be environmentally important(4). Direct photolysis is not expected to be an important environmental fate process since tetrachloroethylene only absorbs light weakly in the environmental UV spectrum(5). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Cleaning agent; Refrigerants; Not Known or Reasonably Ascertainable; Adhesion/cohesion promoter; Intermediate; Processing aids, specific to petroleum production; Laboratory chemicals; Solvent; Other; Processing aids not otherwise specified Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Primary dry cleaning solvent being used today; [Ladou, p. 552] Used in dry cleaning, metal degreasing, as a chemical intermediate, and in typewriter correction fluids; [HSDB] Dry cleaning operators who transferred wet garments to a dryer had mean levels of 150 ppm. Other job tasks with substantial exposure were degreasing (95 ppm), cleaning mining equipment, testing coal, cleaning animal coats (taxidermy), and cleaning/duplicating film. [PMID 18949603] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Restricted Notes: Sales of perchloroethylene in Sweden dropped about 95% between the early 1970s and 30 years later due to regulations and changes in dry-cleaning operations. [PMID 20886350] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Working with Glues and Adhesives [Category: Other]; Dry Cleaning [Category: Clean]; Mining [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Activities with risk of exposure: Preparing and mounting animal skins (taxidermy) [Category: Hobbies] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For tetrachloroethylene (USEPA/OPP Pesticide Code: 078501) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The active ingredient is no longer contained in any registered /pesticide/ products ... "cancelled." Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Dry cleaning; textile processing; degreasing metals; solvent; chemical intermediate in production of fluorocarbons. Insulating fluid and cooling gas in electric transformers Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The major use for tetrachloroethylene is as a chemical intermediate for fluorocarbons, such as HFC-134a and HFC-125. Another important application is the use as a solvent for dry cleaning. ... Other uses are textile finishing and dyeing and extraction processes. In smaller quantities, tetrachloroethylene is used to formulate various types of adhesives, sealants, and coatings. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for Tetrachloroethylene (11 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Tetrachloroethylene is used for dry cleaning of fabrics and for metal-degreasing. It is also used to make other chemicals and is used in some consumer products, such as paint strippers and spot removers. (L116) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
India BIS IS 4707 cosmetic ingredient standards
Source reference
IS 4707 (Part 2):2025 Annex A, entry 312
Source record ID
annex-a:312
Source version
IS 4707 (Part 2):2025, fifth revision
Source language
English
Translation status
Original is English
Effective date
2025-08-09
Source updated
2025-08-09
Snapshot checked
2026-08-31 15:30 UTC
Validation method
206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603

Registered dataset notes

Dataset coverage
Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
Authority note
Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

1931
current India records
1614
records marked Prohibited
1931
records from this source version
1836
market records with CAS identity

Status distribution

Prohibited: 1614Restricted: 317

Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

India market context

Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4

Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.

Verification checklist

  1. Confirm product class and current Cosmetics Rules/gazette amendments.
  2. Check all applicable parts of IS 4707 by exact identity.
  3. Apply Schedule S/other finished-product standards where relevant.
  4. Verify licence/import registration, labelling and testing requirements.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Tetrachloroethylene (CAS No. 127-18-4)” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm product class and current Cosmetics Rules/gazette amendments.
  3. Check all applicable parts of IS 4707 by exact identity.
  4. Apply Schedule S/other finished-product standards where relevant.
  5. Verify licence/import registration, labelling and testing requirements.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECNot supplied
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This official record identifies the substance as prohibited for cosmetic use in the stated market scope. Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

A prohibition entry may contain no separate condition text because the regulatory outcome is the prohibition itself. The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

The record cites IS 4707 (Part 2):2025 Annex A, entry 312, source version IS 4707 (Part 2):2025, fifth revision. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Tetrachloroethylene (CAS No. 127-18-4). IS 4707 (Part 2):2025 Annex A, entry 312. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/14906/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for India

This official record identifies the substance as prohibited for cosmetic use in the stated market scope.

Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Prohibited
  • Legal role: Binding rule
  • Source version: IS 4707 (Part 2):2025, fifth revision
  • Effective date: 2025-08-09

What it does not prove

The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity at the source

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity at the source

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity at the source

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity at the source

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

Research this identity at the source

US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

Research this identity at the source