(isodrin-ISO) (CAS No. 465-73-6) Hydrastine, hydrastinine and their salts (CAS No. 118-08-1/6592-85-4)
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
- Conditions and restrictions
- Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.
Substance identity
- Official source name
- (isodrin-ISO) (CAS No. 465-73-6) Hydrastine, hydrastinine and their salts (CAS No. 118-08-1/6592-85-4)
- CAS
- 465-73-6; 118-08-1; 6592-85-4
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_bis_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
2 linked records
Open supporting recordGreat Britain
2 linked records
Open supporting recordCanada
3 linked records
Open supporting recordNew Zealand
3 linked records
Open supporting recordASEAN
2 linked records
Open supporting recordChina
2 linked records · 2 with specific conditions
Open supporting recordSouth Korea
2 linked records · 1 with specific conditions
Open supporting recordBrazil
2 linked records · 2 with specific conditions
Open supporting recordIndia
Current record1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
2 linked records
Open supporting recordVerified chemistry for CAS 118-08-1
(-)-Hydrastine
- IUPAC name
- (3S)-6,7-dimethoxy-3-[(5R)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one
- Molecular formula
- C21H21NO6
- Molecular weight
- 383.4 g/mol
- Exact mass
- 383.13688739 Da
- Monoisotopic mass
- 383.13688739 Da
- XLogP3
- 2.7
- Topological polar surface area
- 66.5 Ų
- Molecular complexity
- 601.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 28
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:69919
- ChEMBL:CHEMBL1256919
- EPA DTXSID:DTXSID9025409
- PubMed:22814821
- PubMed:22796506
- PubMed:22536197
- PubMed:22224048
- PubMed:22177787
- PubMed:21545305
- PubMed:21372858
- PubMed:21157683
- PubMed:20589732
- PubMed:20550958
- PubMed:20205728
- PubMed:19703289
Advanced structure statistics
- Defined atom stereocentres
- 2
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 11
- 3D rings
- 5
- 3D hydrophobes
- 0
- 3D acceptor features
- 5
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 1
- 3D conformers
- 5
- Effective 3D rotors
- 4.8
Machine-readable structure identifiers
- SMILES
CN1CCC2=CC3=C(C=C2[C@@H]1[C@@H]4C5=C(C(=C(C=C5)OC)OC)C(=O)O4)OCO3- InChI
InChI=1S/C21H21NO6/c1-22-7-6-11-8-15-16(27-10-26-15)9-13(11)18(22)19-12-4-5-14(24-2)20(25-3)17(12)21(23)28-19/h4-5,8-9,18-19H,6-7,10H2,1-3H3/t18-,19+/m1/s1- InChIKey
JZUTXVTYJDCMDU-MOPGFXCFSA-N
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (97.5%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H332 (97.5%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 465-73-6
Isodrin
- IUPAC name
- (1S,2S,3R,6S,7R,8R)-1,8,9,10,11,11-hexachlorotetracyclo[6.2.1.13,6.02,7]dodeca-4,9-diene
- Molecular formula
- C12H8Cl6
- Molecular weight
- 364.9 g/mol
- Exact mass
- 363.872766 Da
- Monoisotopic mass
- 361.875716 Da
- XLogP3
- 4.5
- Topological polar surface area
- 0.0 Ų
- Molecular complexity
- 481.0
- Formal charge
- 0
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 0
- Rotatable bonds
- 0
- Heavy atoms
- 18
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- EPA DTXSID:DTXSID7042065
Advanced structure statistics
- Defined atom stereocentres
- 6
- Undefined atom stereocentres
- 0
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 2
- 3D rings
- 2
- 3D hydrophobes
- 0
- 3D acceptor features
- 0
- 3D donor features
- 0
- 3D anionic centres
- 0
- 3D cationic centres
- 0
- 3D conformers
- 1
- Effective 3D rotors
- 0.4
Machine-readable structure identifiers
- SMILES
C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2[C@@]4(C(=C([C@]3(C4(Cl)Cl)Cl)Cl)Cl)Cl- InChI
InChI=1S/C12H8Cl6/c13-8-9(14)11(16)7-5-2-1-4(3-5)6(7)10(8,15)12(11,17)18/h1-2,4-7H,3H2/t4-,5+,6-,7+,10-,11+- InChIKey
QBYJBZPUGVGKQQ-DIFDVCDBSA-N
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Verified chemistry for CAS 6592-85-4
Hydrastinine
- IUPAC name
- 6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-ol
- Molecular formula
- C11H13NO3
- Molecular weight
- 207.23 g/mol
- Exact mass
- 207.08954328 Da
- Monoisotopic mass
- 207.08954328 Da
- XLogP3
- 1.1
- Topological polar surface area
- 41.9 Ų
- Molecular complexity
- 248.0
- Formal charge
- 0
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 15
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
- ChEBI:CHEBI:233287
- ChEMBL:CHEMBL1623232
- EPA DTXSID:DTXSID3048073
- PubMed:19703289
- PubMed:17645667
- PubMed:17338504
- PubMed:17152992
- PubMed:16780351
- PubMed:15969129
- PubMed:14640583
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 1
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 8
- 3D rings
- 3
- 3D hydrophobes
- 0
- 3D acceptor features
- 3
- 3D donor features
- 1
- 3D anionic centres
- 0
- 3D cationic centres
- 1
- 3D conformers
- 2
- Effective 3D rotors
- 1.4
Machine-readable structure identifiers
- SMILES
CN1CCC2=CC3=C(C=C2C1O)OCO3- InChI
InChI=1S/C11H13NO3/c1-12-3-2-7-4-9-10(15-6-14-9)5-8(7)11(12)13/h4-5,11,13H,2-3,6H2,1H3- InChIKey
YOJQZPVUNUQTDF-UHFFFAOYSA-N
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- India BIS IS 4707 cosmetic ingredient standards
- Source reference
- IS 4707 (Part 2):2025 Annex A, entry 197
- Source record ID
annex-a:197- Source version
- IS 4707 (Part 2):2025, fifth revision
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2025-08-09
- Source updated
- 2025-08-09
- Snapshot checked
- 2026-08-31 15:30 UTC
- Validation method
- 206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
- SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603
Registered dataset notes
- Dataset coverage
- Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
- Authority note
- Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
How this record fits the market dataset
Status distribution
Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
India market context
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.
Verification checklist
- Confirm product class and current Cosmetics Rules/gazette amendments.
- Check all applicable parts of IS 4707 by exact identity.
- Apply Schedule S/other finished-product standards where relevant.
- Verify licence/import registration, labelling and testing requirements.
Official market sources
- India Cosmetics Rules 2020Official CDSCO rules and gazette updates; standards may require separate licensed sources
- India BIS IS 4707 cosmetic ingredient standardsIndian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “(isodrin-ISO) (CAS No. 465-73-6) Hydrastine, hydrastinine and their salts (CAS No. 118-08-1/6592-85-4)” and every CAS/EC identifier refer to the material in your supplier specification.
- Confirm product class and current Cosmetics Rules/gazette amendments.
- Check all applicable parts of IS 4707 by exact identity.
- Apply Schedule S/other finished-product standards where relevant.
- Verify licence/import registration, labelling and testing requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textAvailable
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
(isodrin-ISO) (CAS No. 465-73-6) Hydrastine, hydrastinine and their salts (CAS No. 118-08-1/6592-85-4). IS 4707 (Part 2):2025 Annex A, entry 197. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/14791/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for India
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: IS 4707 (Part 2):2025, fifth revision
- Effective date: 2025-08-09
What it does not prove
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source