1, 3-dimethylpentylamine and its salts (CAS No. 105-41-9)
IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
Regulatory decision and full conditions
- Status
- Prohibited
- Legal role
- Binding rule
- Regulatory summary
- IS 4707 Part 2:2025 Annex A lists this ingredient as one that must not form part of a cosmetic product in India.
- Conditions and restrictions
- Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.
Substance identity
- Official source name
- 1, 3-dimethylpentylamine and its salts (CAS No. 105-41-9)
- CAS
- 105-41-9
- EC
- Not supplied in this source row
- Identity mapping
- standalone:official_bis_record
Cross-market snapshot for this identity
Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.
European Union
1 linked record
Open supporting recordGreat Britain
1 linked record
Open supporting recordCanada
1 linked record
Open supporting recordNew Zealand
1 linked record
Open supporting recordASEAN
1 linked record
Open supporting recordChina
1 linked record · 1 with specific conditions
Open supporting recordSouth Korea
1 linked record · 1 with specific conditions
Open supporting recordBrazil
1 linked record · 1 with specific conditions
Open supporting recordIndia
Current record1 linked record · 1 with specific conditions
Open supporting recordSaudi Arabia
1 linked record
Open supporting recordVerified chemistry for CAS 105-41-9
1,3-Dimethylamylamine
Methylhexaneamine is an alkylamine. — ChEBI
- IUPAC name
- 4-methylhexan-2-amine
- Molecular formula
- C7H17N
- Molecular weight
- 115.22 g/mol
- Exact mass
- 115.136099547 Da
- Monoisotopic mass
- 115.136099547 Da
- XLogP3
- 1.9
- Topological polar surface area
- 26.0 Ų
- Molecular complexity
- 52.0
- Formal charge
- 0
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 1
- Rotatable bonds
- 3
- Heavy atoms
- 8
- Covalent units
- 1
Names and synonyms reported to PubChem
16 more reported names
External database identifiers
Advanced structure statistics
- Defined atom stereocentres
- 0
- Undefined atom stereocentres
- 2
- Defined bond stereocentres
- 0
- Undefined bond stereocentres
- 0
- 3D pharmacophore features
- 4
- 3D rings
- 0
- 3D hydrophobes
- 2
- 3D acceptor features
- 0
- 3D donor features
- 1
- 3D anionic centres
- 0
- 3D cationic centres
- 1
- 3D conformers
- 10
- Effective 3D rotors
- 3.0
Machine-readable structure identifiers
- SMILES
CCC(C)CC(C)N- InChI
InChI=1S/C7H17N/c1-4-6(2)5-7(3)8/h6-7H,4-5,8H2,1-3H3- InChIKey
YAHRDLICUYEDAU-UHFFFAOYSA-N
Evidence from additional scientific databases
EMBL-EBI ChEBI
methylhexaneamine
- Formula
- C7H17N
- Average mass
- 115.220 g/mol
- Monoisotopic mass
- 115.13610 Da
- Formal charge
- 0
- alkylamine — is a (CHEBI:13759)
- alkylamine — is a (CHEBI:13759)
Additional curated names
Cross-references from this source
- CAS: 105-41-9 — DrugCentral
- MANUAL_X_REF: 3353 — DrugCentral
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-02-23. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 132.5 °C Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.7655 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Odor: Amine odor Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: Index of Refraction: 1.4150 at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Slightly soluble in water; very soluble in ethanol, ether, chloroform and dilute acid Source: Hazardous Substances Data Bank (HSDB)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P319, P321, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Environmental Bioconcentration: An estimated BCF of 12 was calculated in fish for 1,3-dimethylamylamine(SRC), using an estimated log Kow of 2.16(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a structure estimation method(2), indicates that 1,3-dimethylamylamine is expected to have moderate mobility in soil(SRC). The pKa of 1,3-dimethylamylamine is estimated to be 10.6(SRC) based on analogy to similar amines(3), indicating that this compound will exist primarily in cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of 1,3-dimethylamylamine from moist soil surfaces may occur(SRC) given an estimated Henry's Law constant of 4.2X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 1,3-Dimethylamylamine is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 8.9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Environmental biodegradation data specific to 1,3-dimethylamylamine were not available(SRC, 2014). However, similar aliphatic amines (such as amylamine and sec-butylamine) have been classified as readily biodegradable using the Japanese MITI test where these aliphatic am Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a structure estimation method(2), indicates that 1,3-dimethylamylamine may have moderate adsorption to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.2X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.1 and 11.1 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 12(SRC), from an estimated log Kow of 2.16(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low. 1,3-Dimethylamylamine is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Environmental biodegradation data specific to 1,3-dimethylamylamine were not available(SRC, 2014). However, similar aliphatic amines (such as amylamine and sec-butylamine) have been classified as readily biodegradable using the Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,3-dimethylamylamine, which has an estimated vapor pressure of 8.9 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,3-dimethylamylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 8 hours(SRC), calculated from its rate constant of 4.9X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). 1,3-Dimethylamylamine does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Uses: DMAA (1,3-dimethylamylamine) is an amphetamine derivative that has been widely used in sports supplements sold in the United States. Also known as methylhexanamine or geranium extract, DMAA is often touted as a "natural" stimulant, with many claimed functional uses including a body-building aid, an athletic performance enhancer, and a weight-loss aid. Although DMAA at one time was approved as a drug for nasal decongestion, no medical use of DMAA is recognized today. FDA is not aware of any reliable science indicating that DMAA exists naturally in plants. Source: Hazardous Substances Data Bank (HSDB)
- Uses: THERAPEUTIC CATEGORY: Adrenergic Source: Hazardous Substances Data Bank (HSDB)
- Uses: /Former Use/ MEDICATION Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Official source and provenance
- Registered source
- India BIS IS 4707 cosmetic ingredient standards
- Source reference
- IS 4707 (Part 2):2025 Annex A, entry 30
- Source record ID
annex-a:30- Source version
- IS 4707 (Part 2):2025, fifth revision
- Source language
- English
- Translation status
- Original is English
- Effective date
- 2025-08-09
- Source updated
- 2025-08-09
- Snapshot checked
- 2026-08-31 15:30 UTC
- Validation method
- 206 text layers; Annex A 1-1614 and Annex B 1-313 with seven lettered source rows
- SHA-256
905dd0326361c53da8a354b948331946951ac3ae27d60d8e2474efb051239603
Registered dataset notes
- Dataset coverage
- Complete current Part 2:2025 Annex A prohibited and Annex B restricted rows; Parts 1, 3 and 4 remain linked official checks
- Authority note
- Indian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
How this record fits the market dataset
Status distribution
Condition text is present on 1931 of 1931 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.
India market context
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Coverage version: Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
All 1,614 prohibited Annex A rows and 317 numbered/lettered restricted Annex B rows from IS 4707 Part 2:2025; official checks remain for colourants, preservatives and UV filters in Parts 1, 3 and 4.
Verification checklist
- Confirm product class and current Cosmetics Rules/gazette amendments.
- Check all applicable parts of IS 4707 by exact identity.
- Apply Schedule S/other finished-product standards where relevant.
- Verify licence/import registration, labelling and testing requirements.
Official market sources
- India Cosmetics Rules 2020Official CDSCO rules and gazette updates; standards may require separate licensed sources
- India BIS IS 4707 cosmetic ingredient standardsIndian Standards referenced by the cosmetics regulatory framework; use the controlled current editions
Verification workflow and record completeness
Before using this result in a compliance decision
- Confirm that “1, 3-dimethylpentylamine and its salts (CAS No. 105-41-9)” and every CAS/EC identifier refer to the material in your supplier specification.
- Confirm product class and current Cosmetics Rules/gazette amendments.
- Check all applicable parts of IS 4707 by exact identity.
- Apply Schedule S/other finished-product standards where relevant.
- Verify licence/import registration, labelling and testing requirements.
- Document the source version and recheck the regulator before manufacture, notification or market placement.
Fields available in this record
- Official substance nameAvailable
- CASAvailable
- ECNot supplied
- Separate condition textAvailable
- Effective dateAvailable
- Snapshot hash and methodAvailable
Questions this page answers
Stable citation
1, 3-dimethylpentylamine and its salts (CAS No. 105-41-9). IS 4707 (Part 2):2025 Annex A, entry 30. India. Source version IS 4707 (Part 2):2025, fifth revision. CosIng Checker regulatory record: https://cosingchecker.com/regulations/in/records/14624/
Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.
Interpretation and limits for India
This official record identifies the substance as prohibited for cosmetic use in the stated market scope.
Do not rely on a formulation containing this identity until the cited source, effective date and exact substance match have been verified.
How to interpret the legal role
The cited row forms part of a binding rule or legally incorporated list for this market.
Evidence on this page
- Recorded outcome: Prohibited
- Legal role: Binding rule
- Source version: IS 4707 (Part 2):2025, fifth revision
- Effective date: 2025-08-09
What it does not prove
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Further authoritative substance research
These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identity at the sourceFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identity at the sourceILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identity at the sourceJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identity at the sourceNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identity at the sourceOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identity at the sourceUS EPA CompTox CTX APIs
API key required for importDTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identity at the source