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Benzophenone-3

The consolidated GB Cosmetics Regulation lists this record in Annex VI.

All Great Britain recordsOpen ingredient profileCompare all marketsOpen official source

Regulatory decision and full conditions

Status
Permitted list with conditions
Legal role
Binding rule
Regulatory summary
The consolidated GB Cosmetics Regulation lists this record in Annex VI.
Conditions and restrictions
Product types— (a) skin products, other than those listed in paragraph (b), including all propellant and pump spray skin products; (b) face products, hand products and lip products (excluding propellant and pump spray face products, hand products and lip products); (c) all other cosmetic products. · For product types— (a) 2.2%; (b) 6%; (c) 0.5%. · For product types (a) and (b), not to be used at more than 0.5% to protect product formulation. If used at 0.5% to protect product formulation, the levels used as UV filter must not exceed, for product types— (a) 1.7%; (b) 5.5%. · Contains Benzophenone-3

Substance identity

Official source name
Benzophenone-3
CAS
131-57-7
EC
205-031-5
Identity mapping
cas_number
Linked ingredient
BENZOPHENONE-3
Search this identity across the siteCAS 131-57-7EC 205-031-5

Linked CosIng identity data

Names and aliases

BENZOPHENONE-3oxybenzone

CosIng description: 2-Hydroxy-4-methoxybenzophenone

EU inventory restriction note: VI/4

Recorded cosmetic function: LIGHT STABILIZER, UV ABSORBER, UV FILTER

Function pages:LIGHT STABILIZER, UV ABSORBER, UV FILTER

View the complete ingredient profile

Cross-market snapshot for this identity

Exact linked records currently present in this site. An absent market means no imported exact match, not permission to use the substance.

5 market datasets

European Union

Positive-list entry with conditions

1 linked record · 1 with specific conditions

Open supporting record

Great Britain

Current record
Permitted list with conditions

1 linked record · 1 with specific conditions

Open supporting record
PubChem 2D chemical structure for CAS 131-57-7
CAS 131-57-7PubChem CID 4632

Verified chemistry for CAS 131-57-7

2-Hydroxy-4-methoxybenzophenone

IUPAC name
(2-hydroxy-4-methoxyphenyl)-phenylmethanone
Molecular formula
C14H12O3
Molecular weight
228.24 g/mol
Exact mass
228.078644241 Da
Monoisotopic mass
228.078644241 Da
XLogP3
3.6
Topological polar surface area
46.5 Ų
Molecular complexity
258.0
Formal charge
0
Hydrogen-bond donors
1
Hydrogen-bond acceptors
3
Rotatable bonds
3
Heavy atoms
17
Covalent units
1

Names and synonyms reported to PubChem

oxybenzoneBenzophenone-32-Benzoyl-5-methoxyphenolAdvastab 45Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-OxybenzonAnuvex4-Methoxy-2-hydroxybenzophenone
16 more reported names
Ongrostab HMBOxibenzonaUsaf cy-9Spectra-sorb UV 9Chimassorb 90OxybenzonumUvinul 9Syntase 62Uvistat 24Cyasorb UV 9Sunscreen UV-15Uvinul M40Escalol 567NSC-7778Oxibenzonum(2-Hydroxy-4-methoxyphenyl)phenylmethanone
Open full PubChem recordSafety and hazards at PubChemPubChem annotationsChemical classifications3D structure image
External database identifiers
Advanced structure statistics
Defined atom stereocentres
0
Undefined atom stereocentres
0
Defined bond stereocentres
0
Undefined bond stereocentres
0
3D pharmacophore features
5
3D rings
2
3D hydrophobes
0
3D acceptor features
2
3D donor features
1
3D anionic centres
0
3D cationic centres
0
3D conformers
2
Effective 3D rotors
3.0
Machine-readable structure identifiers
SMILES
COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2)O
InChI
InChI=1S/C14H12O3/c1-17-11-7-8-12(13(15)9-11)14(16)10-5-3-2-4-6-10/h2-9,15H,1H3
InChIKey
DXGLGDHPHMLXJC-UHFFFAOYSA-N

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match4632

Attributed physical-property, hazard, environmental and use annotations.

  • Boiling Point: 302 to 320 °F at 5 mmHg (NTP, 1992) Source: CAMEO Chemicals
  • Boiling Point: 155 °C at 5.00E+00 mm Hg Source: DrugBank
  • Substance: 2-Hydroxy-4-methoxybenzophenone Source: NTP Technical Reports
  • NTP Technical Report: TR-597: Toxicology and Carcinogenesis Studies of 2-Hydroxy-4- methoxybenzophenone (CASRN 131-57-7) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (2020 ) Source: NTP Technical Reports
  • Peer Review Date: 12/12/19 Source: NTP Technical Reports
  • Conclusion for Male Rat: Equivocal Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: Equivocal Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
  • Summary: Under the conditions of these 2-year studies, there was equivocal evidence of carcinogenic activity of 2H4MBP exposure in male Hsd:Sprague Dawley SD rats based on the occurrence of malignant meningiomas in the brain. There was equivocal evidence of carcinogenic activity in female Hsd:Sprague Dawley SD rats based on the increased incidence of thyroid C-cell adenomas and the increased incidence of uterine stromal polyps. There was no evidence of carcinogenic activity in male or female B6C3F1/N mice at exposure concentrations of 1,000, 3,000, and 10,000 ppm.; Increases in the incidences of nonneoplastic lesions of the testis in male rats and of the uterus and adrenal cortex in female rats occurred with exposure to 2H4MBP. Increases in the incidences of nonneoplastic lesions of the bone marrow (males and females), spleen (males and females), kidney (males and females), and liver (males) in mice occurred with exposure to 2H4MBP. Source: NTP Technical Reports
  • Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 6% (116 of 1945) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (70.2%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (70.2%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (69.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H400 (14.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411 (24.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1945 reports by companies from 26 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 116 of 1945 reports by companies.; There are 24 notifications provided by 1829 of 1945 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: NITE-CMC
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 2-Hydroxy-4-methoxybenzophenone (Benzophenone-3; BP-3) forms crystals or powder. It is used as an ultraviolet light absorber and stabilizer, especially in plastics and paints. It is also used as a broad-band UV filter in concentrations of up to 10% in sunscreen products alone or in combination with other UV filters. It serves not only to prevent sunburn but also to protect against the photodynamic, photosensitizing, and phototoxic effects of various drugs. HUMAN STUDIES: Photosensitivity to the UV-blocking agent benzophenone-3 has been reported. ANIMAL STUDIES: Benzophenone-3 was not a skin sensitizer in mice. Mice received benzophenone-3 in concentrations of 0; 3,125; 6,250; 12,500; 25,000 and 50,000 ppm in the diet for 13 weeks. The following effects were noted: 554 mg/kg bw/day: no adverse effects noted. 1,246 mg/kg bw/day: increased liver weight. 2,860 mg/kg bw/day: increased liver weight. 6,780 mg/kg bw/day: decreased body weight gain in males and females; increased liver weight; minimal cytoplasmic vacuolisation of hepatocytes. 16,238 mg/kg bw/day: decreased body weight gain in males and females; minimal renal lesions in males; increased liver weight; Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Oxybenzone absorbs UV-A ultraviolet rays, preventing them from reaching the skin. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of 39-160 and 33-156 were reported in fish for 2-hydroxy-4-methoxybenzophenone, using carp (Cyprinus carpio) which were exposed over an 10-week period at respective concentrations of 0.1 and 0.01 mg/L(1). According to a classification scheme(2), this BCF range suggests the bioconcentration in aquatic organisms is moderate to high. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Bioaccumulation and trophic transfer in ecosystems is an important criterion for assessing environmental risks of contaminants. This study investigated bioaccumulation and biomagnification of 13 organic ultraviolet absorbents (UVAs) in marine wildlife organisms in the Pearl River Estuary, South China Sea. The UVAs could accumulate in the organisms with biota - sediment accumulation factors (BSAF) of 0.003-2.152. UV531 was the most abundant and showed the highest tendency to accumulate in the organisms with a median BSAF of 1.105. The UVAs demonstrated species - and compound-specific accumulation in the marine organism. Fishes showed significantly higher capability than the cephalopods and crustaceans in accumulation of the UVAs. Habitat did not demonstrate obvious impact on accumulation of the UVA. On the other hand, benzophenone-3, UV328, and UV234 showed significantly higher concentration in the detritus feeding fishes than carnivorous and planktivorous fishes, suggesting governing effect of dietary habits of the organisms on bioaccumulation of these UVAs. Direct uptake from growth media was a significant exposure pathway of the organisms to the UVAs. The estimated trophic magnif Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 950(SRC), determined from a structure estimation method(2), indicates that 2-hydroxy-4-methoxybenzophenone is expected to have low mobility in soil(SRC). The estimated pKa of 2-hydroxy-4-methoxybenzophenone is 7.1(3), indicating that this compound will exist partially in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the anion from moist soil is not expected because anions do not volatilize(SRC). Volatilization of neutral 2-hydroxy-4-methoxybenzophenone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.5X10-8 atm-cu m/mole(SRC), using a fragment constant estimation method(5). 2-Hydroxy-4-methoxybenzophenone is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 6.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). A 4% of Theoretical BOD using activated sludge in the Japanese MITI test suggests that 2-hydroxy-4-methoxybenzophenone is no Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 950(SRC), determined from a structure estimation method(2), indicates that 2-hydroxy-4-methoxybenzophenone is expected to adsorb to suspended solids and sediment(SRC). An estimated pKa of 7.1(3) indicates 2-hydroxy-4-methoxybenzophenone will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces of the anion is not expected to be an important fate process(SRC). Volatilization from water surfaces of neutral 2-hydroxy-4-methoxybenzophenone is not expected(4) based upon an estimated Henry's Law constant of 1.5X10-8 atm-cu m/mole(SRC), developed using a fragment constant estimation method(5). 2-Hydroxy-4-methoxybenzophenone did not undergo hydrolysis or volatilization in sterile controls incubated at 25 °C for 42 days(6). According to a classification scheme(7), BCFs of 33-160, reported for 2-hydroxy-4-methoxybenzophenone in carp (Cyprinus carpio), exposed over an 10-week period(8), suggest bioconcentration in aquatic organisms is moderate to high. 2-Hydroxy-4-methoxybenzophenone may biodegrade, based on half-lives of 10.7 and 4.2-8.7 days under aerobic and Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-hydroxy-4-methoxybenzophenone, which has an estimated vapor pressure of 6.6X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2-hydroxy-4-methoxybenzophenone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.9 hours(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase 2-hydroxy-4-methoxybenzophenone may be removed from the air by wet and dry deposition(SRC). 2-Hydroxy-4-methoxybenzophenone absorbs light at maximum of 287 nm with absorption extending to 400 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Official source and provenance

Registered source
Great Britain Cosmetics Regulation — consolidated Annexes II–VI and amendments
Source reference
GB Cosmetics Regulation, Annex VI, entry 4
Source record ID
VI-4
Source version
2026-08-15
Source language
English
Translation status
Original is English
Effective date
2026-08-15
Source updated
2026-08-19
Snapshot checked
2026-08-30 04:51 UTC
Validation method
legislation.gov.uk XML table parse; {'II': 1758, 'III': 326, 'IV': 154, 'V': 57, 'VI': 34}
SHA-256
e3a386d950f54c6e7a7f9e784d1bd46e52de725137e89d5630709824475215d8

Registered dataset notes

Dataset coverage
Complete consolidated GB Annexes II–VI, with later amendments versioned separately
Authority note
Binding GB schedules and versioned amendments to retained Regulation 1223/2009; applies to England, Wales and Scotland, not Northern Ireland
Source licence
Open Government Licence v3.0 / Crown copyright
Attribution
Contains public sector information licensed under the Open Government Licence v3.0.
Inspect the exact official sourceRegulator guidance

How this record fits the market dataset

2329
current Great Britain records
245
records marked Permitted list with conditions
2329
records from this source version
2015
market records with CAS identity

Status distribution

Permitted list with conditions: 245Prohibited: 1758Restricted: 326

Condition text is present on 517 of 2329 current records. An empty condition field is interpreted according to the record type above; it is never converted into an unrestricted-use claim.

Great Britain market context

Complete consolidated annex dataset

Coverage version: GB retained Regulation 1223/2009 schedules, effective 15 August 2026

Current consolidated Annexes II–VI for England, Scotland and Wales.

Verification checklist

  1. Confirm INCI/CAS/EC identity.
  2. Review every current GB Annex II–VI match.
  3. Check commencement dates and later statutory instruments.
  4. Verify SCPN, responsible-person, safety-report and labelling duties.

Official market sources

Verification workflow and record completeness

Before using this result in a compliance decision

  1. Confirm that “Benzophenone-3” and every CAS/EC identifier refer to the material in your supplier specification.
  2. Confirm INCI/CAS/EC identity.
  3. Review every current GB Annex II–VI match.
  4. Check commencement dates and later statutory instruments.
  5. Verify SCPN, responsible-person, safety-report and labelling duties.
  6. Document the source version and recheck the regulator before manufacture, notification or market placement.

Fields available in this record

  • Official substance nameAvailable
  • CASAvailable
  • ECAvailable
  • Separate condition textAvailable
  • Effective dateAvailable
  • Snapshot hash and methodAvailable

Questions this page answers

This identity appears on a market positive list for the list function represented by the source record. Confirm that the intended function and product use fall within the list scope and every stated condition.

Positive-list presence is purpose-specific and is not blanket approval for every cosmetic use. No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

The record cites GB Cosmetics Regulation, Annex VI, entry 4, source version 2026-08-15. Open the official source.

No. CAS helps resolve identity, but jurisdictions can classify the same substance differently and can apply different product scopes, limits, warnings and transition dates.

Stable citation

Benzophenone-3. GB Cosmetics Regulation, Annex VI, entry 4. Great Britain. Source version 2026-08-15. CosIng Checker regulatory record: https://cosingchecker.com/regulations/gb/records/6655/

Cite the regulator as the legal authority. This page is a structured evidence index and verification aid, not a substitute for the official text or professional legal assessment.

Interpretation and limits for Great Britain

This identity appears on a market positive list for the list function represented by the source record.

Confirm that the intended function and product use fall within the list scope and every stated condition.

How to interpret the legal role

The cited row forms part of a binding rule or legally incorporated list for this market.

Evidence on this page

  • Recorded outcome: Permitted list with conditions
  • Legal role: Binding rule
  • Source version: 2026-08-15
  • Effective date: 2026-08-15

What it does not prove

No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.

Further authoritative substance research

These sources can add identity, safety, exposure or hazard context. A link is not evidence that the database contains this exact substance, and none of these sources overrides the market decision above.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity at the source

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

API key required for import

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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